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ONTOLOGY REPORT - ANNOTATIONS


Term:subacute sclerosing panencephalitis
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Accession:DOID:8970 term browser browse the term
Definition:A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
Synonyms:exact_synonym: Immunosuppressive measles encephalitis;   SSPE;   Subacute Sclerosing Leukoencephalitis;   Subacute Sclerosing Panencephalitides;   Van Bogaert Leukoencephalitis;   Van Bogaert's leukoencephalitis;   Van Bogaert's sclerosing leukoencephalitis;   Van Bogaerts leukoencephalitis;   inclusion body encephalitis, measles;   subacute sclerosing leukoencephalitides;   subacute sclerosing leukoencephalopathy
 primary_id: MESH:D013344
 alt_id: OMIM:260470;   RDO:0001871
 xref: GARD:7708;   NCI:C85171
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Nasu-Hakola disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:8554872
G Tyrobp Tyro protein tyrosine kinase binding protein JBrowse link 1 88,875,370 88,879,305 RGD:7240710
RGD:8554872

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  disease 14924
    disease by infectious agent 810
      viral infectious disease 491
        subacute sclerosing panencephalitis 2
          Nasu-Hakola disease 2
Path 2
Term Annotations click to browse term
  disease 14924
    disease by infectious agent 810
      viral infectious disease 491
        RNA Virus Infections 350
          Mononegavirales Infections 68
            Paramyxoviridae Infections 56
              Morbillivirus Infections 5
                measles 5
                  subacute sclerosing panencephalitis 2
                    Nasu-Hakola disease 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.