Term:Manganese Poisoning
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Accession:DOID:9000304 term browser browse the term
Definition:Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON'S DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
Synonyms:exact_synonym: Manganese Neurotoxicity Syndrome;   Manganese Neurotoxicity Syndromes;   Nervous System Diseases, Manganese Induced;   Nervous System Poisoning, Manganese
 primary_id: MESH:D020149;   RDO:0007318
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Manganese Poisoning term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:4144152
G Atp13a2 ATPase cation transporting 13A2 JBrowse link 5 159,512,208 159,531,631 RGD:11554173
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:11554173
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:11554173
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:11554173
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:11554173
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11554173
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:12910738
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:11554173
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:11554173
G Slc30a10 solute carrier family 30, member 10 JBrowse link 13 103,396,295 103,406,759 RGD:11554173
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:11554173
G Slc39a14 solute carrier family 39 member 14 JBrowse link 15 51,982,872 52,029,841 RGD:11554173
G Slc39a8 solute carrier family 39 member 8 JBrowse link 2 241,028,851 241,092,584 RGD:11554173
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14823
    Chemically-Induced Disorders 1145
      Poisoning 665
        Manganese Poisoning 16
Path 2
Term Annotations click to browse term
  disease 14823
    disease of anatomical entity 13997
      nervous system disease 9111
        toxic encephalopathy 156
          Heavy Metal Poisoning, Nervous System 82
            Manganese Poisoning 16
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.