Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Brain Death
go back to main search page
Accession:DOID:9000774 term browser browse the term
Definition:A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Synonyms:exact_synonym: Brain Dead;   Brain Deads;   Coma Depasse;   Irreversible Coma
 primary_id: MESH:D001926;   RDO:0005057
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for chinchilla.
show annotations for term's descendants           Sort by:
Brain Death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 treatment ISO mRNA, protein:increased expression:kidney RGD PMID:20819234, PMID:23356498 RGD:10755728, RGD:10766439 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO mRNA:increased expression:lung (rat) RGD PMID:20810760 RGD:4145365 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
JBrowse link
G Inhbb inhibin subunit beta B ISO mRNA:increased expression:kidney (rat) RGD PMID:15808645 RGD:9743920 NCBI chrNW_004955459:9,482,998...9,488,489
Ensembl chrNW_004955459:9,482,873...9,488,489
JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 ISO RGD PMID:23157661 RGD:7495829 NCBI chrNW_004955467:5,188,036...5,295,570
Ensembl chrNW_004955467:5,187,356...5,307,692
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:23157661 RGD:7495829 NCBI chrNW_004955478:3,331,607...3,448,840
Ensembl chrNW_004955478:3,331,607...3,448,842
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11834
    Pathological Conditions, Signs and Symptoms 7128
      Pathologic Processes 5198
        Death 122
          Brain Death 5
Path 2
Term Annotations click to browse term
  disease 11834
    disease of anatomical entity 11389
      nervous system disease 9331
        central nervous system disease 7910
          brain disease 7316
            disease of mental health 5339
              cognitive disorder 1601
                Consciousness Disorders 23
                  Unconsciousness 23
                    Coma 9
                      Brain Death 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.