ONTOLOGY REPORT - ANNOTATIONS


Term:Proteostasis Deficiencies
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Accession:DOID:9000842 term browser browse the term
Definition:Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.
Synonyms:exact_synonym: Protein Folding Disease;   Protein Folding Diseases;   Protein Folding Disorder;   Protein Folding Disorders;   Protein Misfolding Disease;   Protein Misfolding Diseases;   Protein Misfolding Disorder;   Protein Misfolding Disorders;   Proteostasis Deficiency;   Proteostasis Dysfunction;   Proteostasis Dysfunctions
 primary_id: MESH:D057165;   RDO:0004817
For additional species annotation, visit the Alliance of Genome Resources.


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Amyloid Neuropathies term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:7771547
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:1580527
amyloidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:11554173
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:8694455
G Apcs amyloid P component, serum JBrowse link 13 91,426,621 91,427,417 RGD:1300286
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:11554173
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:11554173
G Csf1 colony stimulating factor 1 JBrowse link 2 210,522,370 210,550,546 RGD:7257581
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:13504835
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:8554872
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:11554173
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:9835365
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:13207414
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10450570
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:10450570
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:1580528
RGD:11554173
G Zdhhc13 zinc finger, DHHC-type containing 13 JBrowse link 1 104,106,211 104,145,045 RGD:11554173
amyotrophic lateral sclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adarb1 adenosine deaminase, RNA-specific, B1 JBrowse link 20 11,972,352 12,101,022 RGD:10755336
RGD:13592920
RGD:13432092
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:5509081
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:1599080
G Ang angiogenin JBrowse link 15 28,022,926 28,028,636 RGD:6892707
RGD:6892718
RGD:6892716
RGD:6892713
G Aox1 aldehyde oxidase 1 JBrowse link 9 64,929,682 65,007,872 RGD:734575
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:12880359
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:5490153
RGD:8662893
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:11561951
G Atox1 antioxidant 1 copper chaperone JBrowse link 10 40,790,850 40,805,886 RGD:13524567
G Atxn2 ataxin 2 JBrowse link 12 40,264,601 40,335,637 RGD:11554173
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:13506907
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:13506803
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:13506797
RGD:13506907
RGD:13506805
RGD:13506803
RGD:13506800
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:13506907
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:13506902
RGD:13506907
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561951
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:13506949
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:13506949
G Bptf bromodomain PHD finger transcription factor JBrowse link 10 95,248,573 95,350,162 RGD:9586057
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:5130169
G C5ar1 complement C5a receptor 1 JBrowse link 1 78,186,777 78,195,132 RGD:5130169
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:8554872
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:5684010
G Camk1g calcium/calmodulin-dependent protein kinase IG JBrowse link 13 112,075,689 112,099,472 RGD:11554173
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:2311466
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:2311466
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:2311466
G Ccr2 C-C motif chemokine receptor 2 RGD:8657363
G Ccs copper chaperone for superoxide dismutase JBrowse link 1 220,075,251 220,096,319 RGD:13524551
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:5490547
RGD:11554173
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:734741
G Cfap410 cilia and flagella associated protein 410 JBrowse link 20 11,417,428 11,424,301 RGD:11554173
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688711
RGD:11554173
G Cntf ciliary neurotrophic factor JBrowse link 1 229,599,009 229,601,032 RGD:734796
G Ctsh cathepsin H JBrowse link 8 97,439,155 97,458,293 RGD:5686391
G Dbr1 debranching RNA lariats 1 JBrowse link 8 107,826,690 107,838,186 RGD:11554173
G Dctn1 dynactin subunit 1 JBrowse link 4 114,876,770 114,896,567 RGD:8554872
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:9589066
G Dpp6 dipeptidyl peptidase like 6 JBrowse link 4 4,021,021 4,943,675 RGD:5687188
RGD:11554173
RGD:5687181
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:2301741
G Epg5 ectopic P-granules autophagy protein 5 homolog JBrowse link 18 74,299,965 74,397,115 RGD:13592920
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10395391
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:5509900
RGD:11554173
RGD:9685710
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6218978
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:11554173
G Gjc2 gap junction protein, gamma 2 JBrowse link 10 45,526,740 45,535,520 RGD:13208591
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:13506239
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509593
RGD:5509619
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:2301741
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:2301741
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:11554173
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:11554173
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:9681450
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:13524575
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:13524575
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:10402056
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:10058964
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:13506949
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:12904708
G Igf2r insulin-like growth factor 2 receptor JBrowse link 1 48,176,095 48,264,482 RGD:2311519
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:6482791
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:13524575
G Kcnj10 potassium voltage-gated channel subfamily J member 10 JBrowse link 13 90,722,945 90,753,338 RGD:8662893
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1580568
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6893397
G Kif1b kinesin family member 1B JBrowse link 5 165,994,803 166,133,497 RGD:12738468
RGD:12738469
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:13592920
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:5508417
G Maml1 mastermind-like transcriptional coactivator 1 JBrowse link 10 35,765,196 35,801,375 RGD:13524575
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:11561951
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:10412312
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:10412312
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:7207054
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:7207054
RGD:13204793
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:7207054
RGD:13204793
G Mobp myelin-associated oligodendrocyte basic protein JBrowse link 8 128,824,420 128,854,492 RGD:11554173
G Mstn myostatin JBrowse link 9 53,310,977 53,315,804 RGD:2303556
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6484130
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6482832
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:6480495
RGD:6480627
RGD:6480625
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:11565111
RGD:11565173
G Mtnr1a melatonin receptor 1A JBrowse link 16 50,339,358 50,358,809 RGD:13524569
G Mtrex Mtr4 exosome RNA helicase JBrowse link 2 44,726,716 44,787,013 RGD:11041891
G Nefh neurofilament heavy JBrowse link 14 85,181,572 85,191,557 RGD:1302518
RGD:13525000
RGD:8554872
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:13525000
RGD:13525006
G Nefm neurofilament medium JBrowse link 15 44,855,307 44,860,604 RGD:9698444
G Nek1 NIMA-related kinase 1 JBrowse link 16 32,321,010 32,439,421 RGD:11554173
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6893397
RGD:10412690
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5509065
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:13524575
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:6480502
RGD:8554872
RGD:11554173
RGD:6480506
RGD:6480504
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6483573
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:11554173
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11554173
G Pon2 paraoxonase 2 JBrowse link 4 30,344,705 30,380,119 RGD:5509925
G Pon3 paraoxonase 3 JBrowse link 4 30,311,981 30,338,679 RGD:5509925
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6484265
RGD:7242019
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:9999418
G Prph peripherin JBrowse link 7 140,742,406 140,746,197 RGD:8554872
G Psmc4 proteasome 26S subunit, ATPase 4 JBrowse link 1 84,978,220 84,986,536 RGD:13592920
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5688235
RGD:11554173
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 JBrowse link 4 49,941,046 50,140,764 RGD:9590123
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:2314289
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:11554173
RGD:8554872
G Runx1 runt-related transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:6482832
G Scfd1 sec1 family domain containing 1 JBrowse link 6 72,124,408 72,202,703 RGD:11554173
G Serpinf1 serpin family F member 1 JBrowse link 10 62,241,750 62,254,145 RGD:8554892
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:11554173
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:2290573
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:5688710
G Slc1a2 solute carrier family 1 member 2 JBrowse link 3 92,518,679 92,665,731 RGD:1302517
RGD:11554173
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:13524567
G Slc6a1 solute carrier family 6 member 1 JBrowse link 4 146,258,842 146,292,176 RGD:11554173
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:2312367
RGD:11554173
RGD:13524551
RGD:8655880
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:11554173
RGD:11561951
G Steap2 STEAP2 metalloreductase JBrowse link 4 25,506,604 25,527,088 RGD:13524567
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687134
RGD:11554173
RGD:5687192
RGD:5687173
RGD:5687158
RGD:5687157
RGD:5687137
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6767572
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:12904653
G Tnfrsf21 TNF receptor superfamily member 21 JBrowse link 9 20,546,159 20,621,051 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:11554173
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:5685032
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:5147832
RGD:8554872
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:5686382
RGD:11554173
RGD:5686384
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:5688230
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1580568
RGD:8554872
G Zfp106 zinc finger protein 106 JBrowse link 3 112,279,782 112,330,288 RGD:13592920
amyotrophic lateral sclerosis type 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ang angiogenin JBrowse link 15 28,022,926 28,028,636 RGD:8554872
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:11554173
G Bsg basigin (Ok blood group) JBrowse link 7 12,875,536 12,882,753 RGD:11554173
G Calb2 calbindin 2 JBrowse link 19 41,482,743 41,509,617 RGD:11554173
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:11554173
G Cd68 Cd68 molecule JBrowse link 10 56,268,726 56,270,605 RGD:11554173
G Cd7 Cd7 molecule JBrowse link 10 110,229,931 110,232,812 RGD:11554173
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:11554173
G Cntf ciliary neurotrophic factor JBrowse link 1 229,599,009 229,601,032 RGD:11554173
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:11554173
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:11554173
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:11554173
G Dbx1 developing brain homeobox 1 JBrowse link 1 104,969,218 104,973,648 RGD:11554173
G Dctn1 dynactin subunit 1 JBrowse link 4 114,876,770 114,896,567 RGD:7240710
RGD:8554872
G Fancg FA complementation group G JBrowse link 5 58,448,060 58,456,416 RGD:8554872
G Fgf6 fibroblast growth factor 6 JBrowse link 4 159,563,798 159,572,333 RGD:11554173
G Fig4 FIG4 phosphoinositide 5-phosphatase JBrowse link 20 45,922,806 46,044,754 RGD:8554872
G Fmo1 flavin containing dimethylaniline monoxygenase 1 JBrowse link 13 80,712,885 80,745,095 RGD:11554173
G Folh1 folate hydrolase 1 JBrowse link 1 150,323,768 150,395,415 RGD:737756
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:11554173
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:8554872
G Gabra1 gamma-aminobutyric acid type A receptor alpha1 subunit JBrowse link 10 27,310,718 27,371,802 RGD:11554173
G Gbx2 gastrulation brain homeobox 2 JBrowse link 9 97,063,265 97,065,855 RGD:11554173
G Gdi1 GDP dissociation inhibitor 1 JBrowse link X 156,400,734 156,407,396 RGD:11554173
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:11554173
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 JBrowse link X 127,561,843 127,829,763 RGD:11554173
G Gsx2 GS homeobox 2 JBrowse link 14 35,650,985 35,652,709 RGD:11554173
G Hsf1 heat shock transcription factor 1 JBrowse link 7 117,538,523 117,565,478 RGD:11554173
G Ina internexin neuronal intermediate filament protein, alpha JBrowse link 1 266,782,835 266,794,389 RGD:11554173
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:11554173
G Jund JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 16 20,485,028 20,486,707 RGD:11554173
G Kif3c kinesin family member 3C JBrowse link 6 27,768,943 27,815,611 RGD:11554173
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:12798528
G Kif5c kinesin family member 5C JBrowse link 3 35,014,157 35,257,417 RGD:12798528
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:11554173
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:11554173
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:8554872
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:11554173
G Nefh neurofilament heavy JBrowse link 14 85,181,572 85,191,557 RGD:7240710
RGD:8554872
G Otog otogelin JBrowse link 1 102,258,124 102,327,201 RGD:11554173
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:11554173
G Penk proenkephalin JBrowse link 5 17,056,412 17,061,762 RGD:11554173
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11554173
G Prph peripherin JBrowse link 7 140,742,406 140,746,197 RGD:7240710
G Rnase4 ribonuclease A family member 4 JBrowse link 15 28,018,040 28,035,395 RGD:8554872
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:11554173
G Selplg selectin P ligand JBrowse link 12 48,577,905 48,579,196 RGD:11554173
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N JBrowse link 6 128,073,344 128,080,878 RGD:11554173
G Setx senataxin JBrowse link 3 7,680,430 7,731,815 RGD:8554872
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:11554173
G Six2 SIX homeobox 2 JBrowse link 6 8,952,572 8,955,893 RGD:11554173
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:11554173
G Sncg synuclein, gamma JBrowse link 16 10,722,110 10,726,648 RGD:13592920
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:7240710
RGD:8554872
RGD:11554173
RGD:8655873
RGD:8655862
RGD:8655618
RGD:737689
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:13592920
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:8554872
G Tiam1 T-cell lymphoma invasion and metastasis 1 JBrowse link 11 29,931,083 30,061,173 RGD:11554173
G Tle3 TLE family member 3, transcriptional corepressor JBrowse link 8 66,296,509 66,342,186 RGD:11554173
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:8554872
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:8554872
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:8554872
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:13592920
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:11554173
G Vps54 VPS54 subunit of GARP complex JBrowse link 14 106,153,407 106,207,715 RGD:13592920
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:11554173
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:11554173
amyotrophic lateral sclerosis type 10 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 11 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fig4 FIG4 phosphoinositide 5-phosphatase JBrowse link 20 45,922,806 46,044,754 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 12 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 14 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 15 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 16 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 17 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:13592920
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 18 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pfn1 profilin 1 JBrowse link 10 57,273,003 57,275,708 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 19 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 20 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 21 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Matr3 matrin 3 JBrowse link 18 28,351,691 28,390,764 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 22 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tuba4a tubulin, alpha 4A JBrowse link 9 82,415,599 82,419,918 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 23 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa11 annexin A11 JBrowse link 16 3,867,193 3,912,043 RGD:8554872
RGD:7240710
Amyotrophic Lateral Sclerosis Type 24 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nek1 NIMA-related kinase 1 JBrowse link 16 32,321,010 32,439,421 RGD:8554872
RGD:7240710
Amyotrophic Lateral Sclerosis Type 25 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:8554872
RGD:7240710
amyotrophic lateral sclerosis type 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Setx senataxin JBrowse link 3 7,680,430 7,731,815 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spg11 SPG11 vesicle trafficking associated, spatacsin JBrowse link 3 113,999,600 114,064,438 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:7240710
RGD:8554872
RGD:9685712
amyotrophic lateral sclerosis type 8 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 9 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ang angiogenin JBrowse link 15 28,022,926 28,028,636 RGD:7240710
RGD:8554872
G Rnase4 ribonuclease A family member 4 JBrowse link 15 28,018,040 28,035,395 RGD:8554872
Amyotrophic Lateral Sclerosis, Autosomal Recessive term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:8554872
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:8554872
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 JBrowse link 3 119,258,189 119,347,084 RGD:5685005
RGD:11554173
RGD:7240710
RGD:5685008
APP-related cerebral amyloid angiopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:11554173
RGD:8554872
RGD:7240710
cerebral amyloid angiopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aoc3 amine oxidase, copper containing 3 JBrowse link 10 89,251,370 89,259,313 RGD:2313919
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:5508213
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:11554173
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:11554173
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:5148012
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:5688166
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:13592920
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1600811
RGD:13801026
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580993
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1331525
Chromosome 3-Linked Frontotemporal Dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:8554872
RGD:7240710
CST3-related cerebral amyloid angiopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:7240710
RGD:8554872
RGD:11554173
Familial Amyloid Polyneuropathies term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:8554872
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:11041730
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:11041730
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:1331525
RGD:11554173
Familial Amyloidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:7241855
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:2314354
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:1601166
RGD:11554173
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:1599858
G Lyz2 lysozyme 2 JBrowse link 7 60,335,968 60,341,264 RGD:1599842
RGD:1599840
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:11554173
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:1580526
RGD:11554173
RGD:1331525
familial visceral amyloidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:7240710
RGD:8554872
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:8554872
RGD:7240710
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:7240710
RGD:8554872
G Lyz2 lysozyme 2 JBrowse link 7 60,335,968 60,341,264 RGD:7240710
RGD:8554872
Finnish type amyloidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:7240710
RGD:8554872
frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:13592920
G Bace2 beta-secretase 2 JBrowse link 11 37,798,397 37,880,624 RGD:13782172
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688398
RGD:8554872
RGD:11554173
RGD:5688721
RGD:5688716
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509588
RGD:8554872
RGD:11554173
RGD:5509612
RGD:5509609
RGD:5509602
RGD:5509589
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:5508418
RGD:8554872
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:1302531
RGD:8554872
RGD:11554173
RGD:10412702
RGD:10412699
RGD:8158108
RGD:7240710
G March4 membrane associated ring-CH-type finger 4 JBrowse link 9 79,781,752 79,898,726 RGD:8554872
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:8554872
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:8554872
G Pou1f1 POU class 1 homeobox 1 JBrowse link 11 2,645,659 2,662,581 RGD:8554872
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:10412726
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:7240710
RGD:8554872
RGD:11554173
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:8554872
RGD:13592920
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:13592920
Frontotemporal Lobar Degeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:10059351
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688397
RGD:11554173
RGD:5688712
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:5509902
RGD:9685710
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:10401634
RGD:11554173
RGD:10401650
RGD:10401647
RGD:10401638
RGD:10401637
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:10412651
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:6480505
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:11554173
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:11554173
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687136
RGD:11554173
RGD:5687172
RGD:5687159
RGD:5687158
G Tmem106b transmembrane protein 106B JBrowse link 4 39,517,679 39,534,491 RGD:11554173
FTDALS1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:7240710
RGD:8554872
RGD:11554173
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:8554872
FTDALS2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 JBrowse link 20 13,665,046 13,666,845 RGD:7240710
RGD:8554872
FTDALS3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:7240710
RGD:8554872
FTDALS4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:8554872
RGD:7240710
gelatinous drop-like corneal dystrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:8699502
G Tacstd2 tumor-associated calcium signal transducer 2 JBrowse link 4 98,341,187 98,342,887 RGD:7240710
RGD:8554872
GRN-related frontotemporal lobar degeneration with TDP43 inclusions term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509604
RGD:8554872
RGD:7240710
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:13592920
Immunoglobulin Light-chain Amyloidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:7207084
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:7207084
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:7207084
Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:7240710
RGD:8554872
Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:8554872
RGD:7240710
Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:7240710
RGD:8554872
inclusion body myopathy with Paget disease of bone and frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:10059681
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:11554173
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:10395280
RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10059681
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:11554173
ITM2B-related cerebral amyloid angiopathy 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:1358403
RGD:8554872
RGD:7240710
ITM2B-related cerebral amyloid angiopathy 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:7240710
RGD:8554872
lattice corneal dystrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfbi transforming growth factor, beta induced JBrowse link 17 8,400,123 8,429,338 RGD:13592920
Lattice Corneal Dystrophy Type 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tgfbi transforming growth factor, beta induced JBrowse link 17 8,400,123 8,429,338 RGD:7240710
RGD:8554872
Muckle-Wells syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:6906895
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:7240710
RGD:8554872
RGD:11554173
Pick's disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:10047401
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:10047401
RGD:10047402
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:10047402
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:5509779
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:7495833
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:7240710
RGD:8554872
RGD:11554173
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:7240710
RGD:8554872
RGD:11554173
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480200
G Sncb synuclein, beta JBrowse link 17 10,384,472 10,392,776 RGD:6480200
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687194
primary cutaneous amyloidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:7771598
G Il31ra interleukin 31 receptor A JBrowse link 2 44,333,347 44,408,005 RGD:11554173
G Osmr oncostatin M receptor JBrowse link 2 56,107,491 56,163,522 RGD:11554173
Primary Localized Cutaneous Amyloidosis, 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Osmr oncostatin M receptor JBrowse link 2 56,107,491 56,163,522 RGD:7240710
RGD:8554872
Primary Localized Cutaneous Amyloidosis, 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il31ra interleukin 31 receptor A JBrowse link 2 44,333,347 44,408,005 RGD:7240710
RGD:8554872
Primary Localized Cutaneous Amyloidosis, 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpnmb glycoprotein nmb JBrowse link 4 78,694,447 78,715,685 RGD:8554872
RGD:7240710
Primary Progressive Nonfluent Aphasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:8554872
Reticulate Pigmentary Disorder, with Systemic Manifestations term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pola1 DNA polymerase alpha 1, catalytic subunit JBrowse link X 62,382,604 62,698,830 RGD:8554872
RGD:7240710
transthyretin amyloidosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:7240710
RGD:8554872

Term paths to the root
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  disease 14920
    Nutritional and Metabolic Diseases 4265
      disease of metabolism 4265
        Proteostasis Deficiencies 246
          TDP-43 Proteinopathies + 213
          amyloidosis + 42
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.