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ONTOLOGY REPORT - ANNOTATIONS


Term:Multiple Primary Neoplasms
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Accession:DOID:9001030 term browser browse the term
Definition:Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Synonyms:exact_synonym: Synchronous Multiple Primary Neoplasms;   Synchronous Neoplasm;   multiple primary neoplasm;   synchronous neoplasms
 primary_id: MESH:D009378
 alt_id: RDO:0005711
For additional species annotation, visit the Alliance of Genome Resources.


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Multiple Primary Neoplasms term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:9589077
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:1625108
Bannayan-Riley-Ruvalcaba syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:8554872
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:8554872
RGD:13592920
Cowden syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:8554872
G Klln killin, p53-regulated DNA replication inhibitor JBrowse link 1 251,417,849 251,420,794 RGD:8554872
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:8554872
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:8554872
RGD:7240710
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:8554872
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:8554872
Cowden Syndrome 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Klln killin, p53-regulated DNA replication inhibitor JBrowse link 1 251,417,849 251,420,794 RGD:7240710
Cowden Syndrome 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:7240710
RGD:8554872
Cowden Syndrome 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:8554872
RGD:7240710
Cowden Syndrome 7 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sec23b Sec23 homolog B, COPII coat complex component JBrowse link 3 138,715,118 138,757,111 RGD:8554872
RGD:7240710
Cowden-Like Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:8554872
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:8554872
familial medullary thyroid carcinoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:8554872
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:8554872
G Prlr prolactin receptor JBrowse link 2 60,131,410 60,325,686 RGD:13592920
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:7240710
RGD:8554872
RGD:11554173
Macrocephaly Mesodermal Hamartoma Spectrum term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:8554872
multiple endocrine neoplasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:2293616
RGD:8554872
G Cdkn1bwe cyclin-dependent kinase inhibitor 1B; white eye mutation RGD:2293616
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:12904888
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:12904888
G Gpr19 G protein-coupled receptor 19 JBrowse link 4 168,639,930 168,668,345 RGD:8554872
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:8554872
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:11554173
RGD:8554872
multiple endocrine neoplasia type 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:2317763
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:2317347
RGD:8554872
RGD:11554173
RGD:7240710
RGD:1601327
RGD:1601326
RGD:2317327
RGD:2317303
RGD:2317313
RGD:2317331
RGD:619590
RGD:2317293
RGD:2317314
RGD:2317334
RGD:2317335
RGD:1581203
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:8554872
multiple endocrine neoplasia type 2A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:2324920
RGD:8554872
RGD:11554173
RGD:7240710
multiple endocrine neoplasia type 2B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:7240710
RGD:8554872
multiple endocrine neoplasia type 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:7240710
RGD:8554872
G Gpr19 G protein-coupled receptor 19 JBrowse link 4 168,639,930 168,668,345 RGD:8554872
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:8554872
Proteus syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:5509063
RGD:8554872
RGD:7240710
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:11554173
RGD:8554872
PTEN hamartoma tumor syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:8554872
G Ankrd22 ankyrin repeat domain 22 JBrowse link 1 252,430,750 252,461,346 RGD:8554872
G Atad1 ATPase family, AAA domain containing 1 JBrowse link 1 251,234,702 251,386,996 RGD:8554872
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:8554872
G Fam25a family with sequence similarity 25, member A JBrowse link 16 10,702,264 10,706,073 RGD:8554872
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:11554173
G Glud1 glutamate dehydrogenase 1 JBrowse link 16 10,661,486 10,695,557 RGD:8554872
G Klln killin, p53-regulated DNA replication inhibitor JBrowse link 1 251,417,849 251,420,794 RGD:8554872
G Lipf lipase F, gastric type JBrowse link 1 252,284,464 252,302,811 RGD:8554872
G Lipk lipase, family member K JBrowse link 1 252,323,865 252,355,893 RGD:8554872
G Lipm lipase, family member M JBrowse link 1 252,409,232 252,428,567 RGD:8554872
G Lipn lipase, family member N JBrowse link 1 252,375,941 252,394,226 RGD:8554872
G Minpp1 multiple inositol-polyphosphate phosphatase 1 JBrowse link 1 251,045,352 251,071,045 RGD:8554872
G Mmrn2 multimerin 2 JBrowse link 16 10,727,552 10,749,303 RGD:8554872
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 JBrowse link 1 251,145,264 251,230,716 RGD:8554872
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:8554872
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1302552
RGD:8554872
RGD:11554173
RGD:12859041
RGD:12859035
RGD:12802361
RGD:12802356
G Rnls renalase, FAD-dependent amine oxidase JBrowse link 1 251,828,285 252,101,963 RGD:8554872
G Shld2 shieldin complex subunit 2 JBrowse link 16 10,570,307 10,661,528 RGD:8554872
G Sncg synuclein, gamma JBrowse link 16 10,722,110 10,726,648 RGD:8554872
G Stambpl1 STAM binding protein-like 1 JBrowse link 1 252,490,125 252,536,113 RGD:8554872
tuberous sclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:9068443
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:1549429
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:11565117
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:11554173
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:8547829
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:1624196
RGD:9068941
RGD:8554872
RGD:11073512
RGD:11570511
RGD:11062248
RGD:11554173
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:8554872
RGD:11062248
RGD:11568672
RGD:11554173
tuberous sclerosis 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase JBrowse link 3 4,374,679 4,394,374 RGD:8554872
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 JBrowse link 3 5,519,921 5,558,390 RGD:8554872
G Adamtsl2 ADAMTS-like 2 JBrowse link 3 5,624,473 5,654,890 RGD:8554872
G Ak8 adenylate kinase 8 JBrowse link 3 7,279,429 7,394,509 RGD:8554872
G Brd3 bromodomain containing 3 JBrowse link 3 5,995,204 6,054,467 RGD:8554872
G Cacfd1 calcium channel flower domain containing 1 JBrowse link 3 5,555,807 5,571,205 RGD:8554872
G Cel carboxyl ester lipase JBrowse link 3 7,134,021 7,141,522 RGD:8554872
G Dbh dopamine beta-hydroxylase JBrowse link 3 5,709,236 5,731,895 RGD:8554872
G Fam163b family with sequence similarity 163, member B JBrowse link 3 5,656,400 5,693,273 RGD:8554872
G Gbgt1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) JBrowse link 3 7,076,582 7,079,652 RGD:8554872
G Gfi1b growth factor independent 1B transcriptional repressor JBrowse link 3 7,190,721 7,203,444 RGD:8554872
G Gtf3c5 general transcription factor IIIC subunit 5 JBrowse link 3 7,144,354 7,164,678 RGD:8554872
G Med22 mediator complex subunit 22 JBrowse link 3 5,453,678 5,458,760 RGD:8554872
G Mymk myomaker, myoblast fusion factor JBrowse link 3 5,608,243 5,617,689 RGD:8554872
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:8554872
G Rexo4 REX4 homolog, 3'-5' exonuclease JBrowse link 3 5,500,578 5,510,908 RGD:8554872
G Rpl7a ribosomal protein L7a JBrowse link 3 5,458,985 5,461,627 RGD:8554872
G Sardh sarcosine dehydrogenase JBrowse link 3 5,737,203 5,802,153 RGD:8554872
G Slc2a6 solute carrier family 2 member 6 JBrowse link 3 5,567,729 5,575,144 RGD:8554872
G Spaca9 sperm acrosome associated 9 JBrowse link 3 7,269,851 7,279,253 RGD:8554872
G Stkld1 serine/threonine kinase-like domain containing 1 JBrowse link 3 5,481,524 5,500,568 RGD:8554872
G Surf1 SURF1, cytochrome c oxidase assembly factor JBrowse link 3 5,461,717 5,464,560 RGD:8554872
G Surf2 surfeit 2 JBrowse link 3 5,464,593 5,468,426 RGD:8554872
G Surf4 surfeit 4 JBrowse link 3 5,468,284 5,481,447 RGD:8554872
G Surf6 surfeit 6 JBrowse link 3 5,441,404 5,452,156 RGD:8554872
G Tsc1 TSC complex subunit 1 JBrowse link 3 7,219,955 7,269,063 RGD:7240710
RGD:8554872
RGD:11570507
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:8554872
G Vav2 vav guanine nucleotide exchange factor 2 JBrowse link 3 5,811,504 5,976,311 RGD:8554872
G Wdr5 WD repeat domain 5 JBrowse link 3 6,061,892 6,080,724 RGD:8554872
tuberous sclerosis 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Antkmt adenine nucleotide translocase lysine methyltransferase JBrowse link 10 15,160,037 15,161,895 RGD:8554872
G Baiap3 BAI1-associated protein 3 JBrowse link 10 14,601,133 14,613,881 RGD:8554872
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:8554872
G Ccdc154 coiled-coil domain containing 154 JBrowse link 10 14,518,240 14,529,920 RGD:8554872
G Ccdc78 coiled-coil domain containing 78 JBrowse link 10 15,155,839 15,160,039 RGD:8554872
G Chtf18 chromosome transmission fidelity factor 18 JBrowse link 10 15,090,762 15,098,825 RGD:8554872
G Ciao3 cytosolic iron-sulfur assembly component 3 JBrowse link 10 15,143,732 15,152,706 RGD:8554872
G Clcn7 chloride voltage-gated channel 7 JBrowse link 10 14,492,844 14,518,167 RGD:8554872
G Cramp1 cramped chromatin regulator homolog 1 JBrowse link 10 14,324,799 14,373,413 RGD:8554872
G Eme2 essential meiotic structure-specific endonuclease subunit 2 JBrowse link 10 14,253,552 14,257,017 RGD:8554872
G Fahd1 fumarylacetoacetate hydrolase domain containing 1 JBrowse link 10 14,214,518 14,215,957 RGD:8554872
G Fbxl16 F-box and leucine-rich repeat protein 16 JBrowse link 10 15,176,489 15,188,729 RGD:8554872
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:8554872
G Gng13 G protein subunit gamma 13 JBrowse link 10 15,088,935 15,090,839 RGD:8554872
G Gnptg N-acetylglucosamine-1-phosphate transferase subunit gamma JBrowse link 10 14,593,050 14,597,995 RGD:8554872
G Hagh hydroxyacyl glutathione hydrolase JBrowse link 10 14,215,913 14,230,506 RGD:8554872
G Haghl hydroxyacylglutathione hydrolase-like JBrowse link 10 15,152,736 15,157,221 RGD:8554872
G Hs3st6 heparan sulfate-glucosamine 3-sulfotransferase 6 JBrowse link 10 14,122,856 14,128,984 RGD:8554872
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:7240710
G Ift140 intraflagellar transport 140 JBrowse link 10 14,373,668 14,461,509 RGD:8554872
G Igfals insulin-like growth factor binding protein, acid labile subunit JBrowse link 10 14,240,308 14,243,554 RGD:8554872
G Jmjd8 jumonji domain containing 8 JBrowse link 10 15,195,954 15,198,870 RGD:8554872
G Jpt2 Jupiter microtubule associated homolog 2 JBrowse link 10 14,304,108 14,324,170 RGD:8554872
G Lmf1 lipase maturation factor 1 JBrowse link 10 14,945,185 15,031,855 RGD:8554872
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 10 14,259,394 14,299,276 RGD:8554872
G Mcrip2 MAPK regulated co-repressor interacting protein 2 JBrowse link 10 15,230,801 15,235,740 RGD:8554872
G Meiob meiosis specific with OB-fold JBrowse link 10 14,174,645 14,206,026 RGD:8554872
G Metrn meteorin, glial cell differentiation regulator JBrowse link 10 15,164,439 15,166,457 RGD:8554872
G Mettl26 methyltransferase like 26 JBrowse link 10 15,239,753 15,255,054 RGD:8554872
G Mrps34 mitochondrial ribosomal protein S34 JBrowse link 10 14,257,001 14,258,132 RGD:8554872
G Msln mesothelin JBrowse link 10 15,119,700 15,129,129 RGD:8554872
G Msrb1 methionine sulfoxide reductase B1 JBrowse link 10 14,105,750 14,111,463 RGD:8554872
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 JBrowse link 10 14,090,128 14,092,289 RGD:8554872
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 JBrowse link 10 14,258,232 14,259,365 RGD:8554872
G Noxo1 NADPH oxidase organizer 1 JBrowse link 10 14,062,331 14,066,918 RGD:8554872
G Npw neuropeptide W JBrowse link 10 14,021,187 14,022,452 RGD:8554872
G Nthl1 nth-like DNA glycosylase 1 JBrowse link 10 13,996,660 14,002,827 RGD:8554872
G Nubp2 nucleotide binding protein 2 JBrowse link 10 14,244,201 14,247,930 RGD:8554872
G Pigq phosphatidylinositol glycan anchor biosynthesis, class Q JBrowse link 10 15,289,530 15,305,593 RGD:8554872
G Pkd1 polycystin 1, transient receptor potential channel interacting JBrowse link 10 13,914,057 13,962,008 RGD:8554872
G Ptx4 pentraxin 4 JBrowse link 10 14,481,044 14,486,277 RGD:8554872
G Rab40c Rab40c, member RAS oncogene family JBrowse link 10 15,247,913 15,283,111 RGD:8554872
G RGD1565784 RGD1565784 JBrowse link 10 14,543,196 14,544,498 RGD:8554872
G Rhbdl1 rhomboid like 1 JBrowse link 10 15,201,503 15,205,856 RGD:8554872
G Rhot2 ras homolog family member T2 JBrowse link 10 15,205,943 15,211,739 RGD:8554872
G Rnf151 ring finger protein 151 JBrowse link 10 14,083,538 14,088,011 RGD:8554872
G Rpl3l ribosomal protein L3-like JBrowse link 10 14,094,769 14,105,312 RGD:8554872
G Rps2 ribosomal protein S2 JBrowse link 10 14,088,171 14,090,020 RGD:8554872
G Rpusd1 RNA pseudouridine synthase domain containing 1 JBrowse link 10 15,099,104 15,102,968 RGD:8554872
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link 10 14,003,330 14,015,066 RGD:8554872
G Sox8 SRY-box transcription factor 8 JBrowse link 10 14,932,348 14,937,336 RGD:8554872
G Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 JBrowse link 10 14,248,199 14,253,815 RGD:8554872
G Sstr5 somatostatin receptor 5 JBrowse link 10 14,847,749 14,853,827 RGD:8554872
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:8554872
G Syngr3 synaptogyrin 3 JBrowse link 10 14,051,413 14,056,169 RGD:8554872
G Tbl3 transducin (beta)-like 3 JBrowse link 10 14,066,984 14,072,197 RGD:8554872
G Telo2 telomere maintenance 2 JBrowse link 10 14,461,581 14,476,812 RGD:8554872
G Tmem204 transmembrane protein 204 JBrowse link 10 14,417,608 14,446,272 RGD:8554872
G Tpsab1 tryptase alpha/beta 1 JBrowse link 10 14,701,253 14,703,668 RGD:8554872
G Tpsb2 tryptase beta 2 JBrowse link 10 14,722,672 14,724,464 RGD:8554872
G Tpsg1 tryptase gamma 1 JBrowse link 10 14,724,531 14,731,259 RGD:8554872
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:7240710
RGD:8554872
RGD:11554173
G Tsr3 TSR3 ribosome maturation factor JBrowse link 10 14,598,014 14,600,576 RGD:8554872
G Ube2i ubiquitin-conjugating enzyme E2I JBrowse link 10 14,618,615 14,639,274 RGD:8554872
G Unkl unk like zinc finger JBrowse link 10 14,547,126 14,593,090 RGD:8554872
G Wdr24 WD repeat domain 24 JBrowse link 10 15,191,078 15,195,860 RGD:8554872
G Wdr90 WD repeat domain 90 JBrowse link 10 15,211,660 15,229,477 RGD:8554872
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 JBrowse link 10 15,243,429 15,245,757 RGD:8554872
G Zfp598 zinc finger protein 598 JBrowse link 10 14,035,114 14,047,100 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16022
    disease of cellular proliferation 5888
      Multiple Primary Neoplasms 141
        Intestinal Polyposis, with Multiple Exostoses 0
        PTEN hamartoma tumor syndrome + 26
        multiple endocrine neoplasia + 12
        tuberous sclerosis + 101
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.