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ONTOLOGY REPORT - ANNOTATIONS


Term:Multiple Primary Neoplasms
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Accession:DOID:9001030 term browser browse the term
Definition:Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Synonyms:exact_synonym: Synchronous Multiple Primary Neoplasms;   Synchronous Neoplasm;   multiple primary neoplasm;   synchronous neoplasms
 primary_id: MESH:D009378
 alt_id: RDO:0005711
For additional species annotation, visit the Alliance of Genome Resources.


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Multiple Primary Neoplasms term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnmt3b DNA methyltransferase 3 beta JBrowse link NW_004936485 19,547,836 19,570,716 RGD:9068941
G Mlh1 mutL homolog 1 JBrowse link NW_004936473 26,556,636 26,600,830 RGD:9068941
Bannayan-Riley-Ruvalcaba syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004936566 3,924,013 3,951,052 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004936735 1,252,414 1,338,318 RGD:9068941
Cowden syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egfr epidermal growth factor receptor JBrowse link NW_004936678 365,005 560,546 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004936566 3,924,013 3,951,052 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004936735 1,252,414 1,338,318 RGD:7240710
G Rint1 RAD50 interactor 1 JBrowse link NW_004936479 18,311,698 18,334,946 RGD:9068941
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link NW_004936474 3,993,224 4,021,359 RGD:9068941
Cowden Syndrome 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004936566 3,924,013 3,951,052 RGD:7240710
Cowden Syndrome 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004936621 620,163 639,115 RGD:7240710
Cowden Syndrome 7 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sec23b SEC23 homolog B, COPII coat complex component JBrowse link NW_004936485 1,743,848 1,781,824 RGD:7240710
Cowden-Like Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004936566 3,924,013 3,951,052 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004936735 1,252,414 1,338,318 RGD:9068941
familial medullary thyroid carcinoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insrr insulin receptor related receptor JBrowse link NW_004936580 5,982,259 5,999,994 RGD:9068941
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link NW_004936580 6,002,168 6,021,690 RGD:9068941
G Ret ret proto-oncogene JBrowse link NW_004936617 2,927,185 2,980,594 RGD:7240710
Macrocephaly Mesodermal Hamartoma Spectrum term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004936621 620,163 639,115 RGD:9068941
multiple endocrine neoplasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin dependent kinase inhibitor 1B JBrowse link NW_004936587 4,573,166 4,578,480 RGD:9068941
G Ghrl ghrelin and obestatin prepropeptide JBrowse link NW_004936602 3,037,862 3,044,863 RGD:9068941
G Ghsr growth hormone secretagogue receptor JBrowse link NW_004936593 268,736 273,623 RGD:9068941
G Gpr19 G protein-coupled receptor 19 JBrowse link NW_004936587 4,596,231 4,633,792 RGD:9068941
G Men1 menin 1 JBrowse link NW_004936599 4,504,489 4,510,085 RGD:9068941
G Ret ret proto-oncogene JBrowse link NW_004936617 2,927,185 2,980,594 RGD:9068941
multiple endocrine neoplasia type 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link NW_004936662 1,886,176 1,928,998 RGD:9068941
G Men1 menin 1 JBrowse link NW_004936599 4,504,489 4,510,085 RGD:7240710
RGD:9068941
G Ret ret proto-oncogene JBrowse link NW_004936617 2,927,185 2,980,594 RGD:9068941
multiple endocrine neoplasia type 2A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ret ret proto-oncogene JBrowse link NW_004936617 2,927,185 2,980,594 RGD:7240710
multiple endocrine neoplasia type 2B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ret ret proto-oncogene JBrowse link NW_004936617 2,927,185 2,980,594 RGD:7240710
multiple endocrine neoplasia type 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin dependent kinase inhibitor 1B JBrowse link NW_004936587 4,573,166 4,578,480 RGD:7240710
G Gpr19 G protein-coupled receptor 19 JBrowse link NW_004936587 4,596,231 4,633,792 RGD:9068941
G Ret ret proto-oncogene JBrowse link NW_004936617 2,927,185 2,980,594 RGD:9068941
Proteus syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004936621 620,163 639,115 RGD:7240710
G Pten phosphatase and tensin homolog JBrowse link NW_004936735 1,252,414 1,338,318 RGD:9068941
PTEN hamartoma tumor syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link NW_004936735 266,918 283,858 RGD:9068941
G Adirf adipogenesis regulatory factor JBrowse link NW_004936804 11,232 13,057 RGD:9068941
G Ankrd22 ankyrin repeat domain 22 JBrowse link NW_004936735 362,399 396,903 RGD:9068941
G Atad1 ATPase family AAA domain containing 1 JBrowse link NW_004936735 1,377,168 1,423,696 RGD:9068941
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link NW_004936804 52,435 115,289 RGD:9068941
G Fam25a family with sequence similarity 25 member A JBrowse link NW_004936601 5,442,940 5,445,804 RGD:9068941
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link NW_004936486 10,506,680 10,606,272 RGD:9068941
G Glud1 glutamate dehydrogenase 1 JBrowse link NW_004936601 5,415,857 5,435,964 RGD:9068941
G Lipf lipase F, gastric type JBrowse link NW_004936735 553,438 568,021 RGD:9068941
G Lipk lipase family member K JBrowse link NW_004936735 481,668 505,770 RGD:9068941
G Lipm lipase family member M JBrowse link NW_004936735 399,567 418,264 RGD:9068941
G Lipn lipase family member N JBrowse link NW_004936735 445,985 464,340 RGD:9068941
G Minpp1 multiple inositol-polyphosphate phosphatase 1 JBrowse link NW_004936735 1,585,741 1,627,910 RGD:9068941
G Mmrn2 multimerin 2 JBrowse link NW_004936804 22,609 39,974 RGD:9068941
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 JBrowse link NW_004936735 1,437,108 1,516,382 RGD:9068941
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link NW_004936566 3,924,013 3,951,052 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004936735 1,252,414 1,338,318 RGD:9068941
G Rnls renalase, FAD dependent amine oxidase JBrowse link NW_004936735 659,826 1,048,135 RGD:9068941
G Shld2 shieldin complex subunit 2 JBrowse link NW_004936601 5,315,297 5,400,752 RGD:9068941
G Sncg synuclein gamma JBrowse link NW_004936804 16,869 21,684 RGD:9068941
G Stambpl1 STAM binding protein like 1 JBrowse link NW_004936735 293,833 337,839 RGD:9068941
tuberous sclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link NW_004936697 1,054,237 1,061,468 RGD:9068941
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link NW_004936710 1,446,030 1,461,945 RGD:9068941
G Flna filamin A JBrowse link NW_004936809 1,097,288 1,123,206 RGD:9068941
G Ifng interferon gamma JBrowse link NW_004936545 6,139,130 6,144,543 RGD:9068941
G Mmp9 matrix metallopeptidase 9 JBrowse link NW_004936514 7,038,240 7,045,873 RGD:9068941
G Tsc1 TSC complex subunit 1 JBrowse link NW_004936487 19,331,183 19,386,841 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004936694 1,958,152 1,993,373 RGD:9068941
tuberous sclerosis 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase JBrowse link NW_004936570 1,315,192 1,322,719 RGD:9068941
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 JBrowse link NW_004936669 3,449,259 3,478,471 RGD:9068941
G Adamtsl2 ADAMTS like 2 JBrowse link NW_004936669 3,363,991 3,397,099 RGD:9068941
G Ak8 adenylate kinase 8 JBrowse link NW_004936487 19,212,155 19,321,601 RGD:9068941
G Brd3 bromodomain containing 3 JBrowse link NW_004936669 2,993,284 3,023,185 RGD:9068941
G Cacfd1 calcium channel flower domain containing 1 JBrowse link NW_004936669 3,439,174 3,448,637 RGD:9068941
G Cel carboxyl ester lipase JBrowse link NW_004936487 19,463,219 19,472,029 RGD:9068941
G Dbh dopamine beta-hydroxylase JBrowse link NW_004936669 3,302,014 3,326,233 RGD:9068941
G Fam163b family with sequence similarity 163 member B JBrowse link NW_004936669 3,337,490 3,363,077 RGD:9068941
G Gbgt1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) JBrowse link NW_004936487 19,520,232 19,529,199 RGD:9068941
G Gfi1b growth factor independent 1B transcriptional repressor JBrowse link NW_004936487 19,414,135 19,417,465 RGD:9068941
G Gtf3c5 general transcription factor IIIC subunit 5 JBrowse link NW_004936487 19,438,537 19,455,712 RGD:9068941
G LOC101971854 surfeit locus protein 1 JBrowse link NW_004936669 3,527,741 3,532,087 RGD:9068941
G Med22 mediator complex subunit 22 JBrowse link NW_004936669 3,535,646 3,541,643 RGD:9068941
G Mymk myomaker, myoblast fusion factor JBrowse link NW_004936669 3,404,729 3,413,123 RGD:9068941
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link NW_004936487 19,475,361 19,501,347 RGD:9068941
G Rexo4 REX4 homolog, 3'-5' exonuclease JBrowse link NW_004936669 3,479,778 3,504,938 RGD:9068941
G Rpl7a ribosomal protein L7a JBrowse link NW_004936669 3,532,139 3,534,586 RGD:9068941
G Sardh sarcosine dehydrogenase JBrowse link NW_004936669 3,244,302 3,297,906 RGD:9068941
G Slc2a6 solute carrier family 2 member 6 JBrowse link NW_004936669 3,432,206 3,438,849 RGD:9068941
G Spaca9 sperm acrosome associated 9 JBrowse link NW_004936487 19,322,207 19,331,434 RGD:9068941
G Stkld1 serine/threonine kinase like domain containing 1 JBrowse link NW_004936669 3,492,507 3,511,297 RGD:9068941
G Surf2 surfeit 2 JBrowse link NW_004936669 3,524,070 3,527,697 RGD:9068941
G Surf4 surfeit 4 JBrowse link NW_004936669 3,518,616 3,523,808 RGD:9068941
G Surf6 surfeit 6 JBrowse link NW_004936669 3,543,250 3,548,756 RGD:9068941
G Tsc1 TSC complex subunit 1 JBrowse link NW_004936487 19,331,183 19,386,841 RGD:7240710
RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004936694 1,958,152 1,993,373 RGD:9068941
G Vav2 vav guanine nucleotide exchange factor 2 JBrowse link NW_004936669 3,062,538 3,234,167 RGD:9068941
G Wdr5 WD repeat domain 5 JBrowse link NW_004936669 2,943,759 2,959,788 RGD:9068941
tuberous sclerosis 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Antkmt adenine nucleotide translocase lysine methyltransferase JBrowse link NW_004936501 294,318 295,311 RGD:9068941
G Baiap3 BAI1 associated protein 3 JBrowse link NW_004936694 2,542,521 2,556,540 RGD:9068941
G C1qtnf8 C1q and TNF related 8 JBrowse link NW_004936501 53,208 54,391 RGD:9068941
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link NW_004936694 2,702,224 2,724,574 RGD:9068941
G Ccdc154 coiled-coil domain containing 154 JBrowse link NW_004936694 2,468,281 2,475,901 RGD:9068941
G Ccdc78 coiled-coil domain containing 78 JBrowse link NW_004936501 289,765 294,272 RGD:9068941
G Chtf18 chromosome transmission fidelity factor 18 JBrowse link NW_004936501 232,387 240,866 RGD:9068941
G Ciao3 cytosolic iron-sulfur assembly component 3 JBrowse link NW_004936501 277,525 286,929 RGD:9068941
G Clcn7 chloride voltage-gated channel 7 JBrowse link NW_004936694 2,444,321 2,467,734 RGD:9068941
G Cramp1 cramped chromatin regulator homolog 1 JBrowse link NW_004936694 2,284,315 2,341,033 RGD:9068941
G CUNH16orf91 chromosome unknown C16orf91 homolog JBrowse link NW_004936694 2,484,092 2,485,012 RGD:9068941
G Eme2 essential meiotic structure-specific endonuclease subunit 2 JBrowse link NW_004936694 2,217,352 2,220,556 RGD:9068941
G Fahd1 fumarylacetoacetate hydrolase domain containing 1 JBrowse link NW_004936694 2,179,730 2,181,296 RGD:9068941
G Fbxl16 F-box and leucine rich repeat protein 16 JBrowse link NW_004936501 308,682 320,774 RGD:9068941
G Gfer growth factor, augmenter of liver regeneration JBrowse link NW_004936694 2,051,362 2,053,812 RGD:9068941
G Gng13 G protein subunit gamma 13 JBrowse link NW_004936501 230,439 232,426 RGD:9068941
G Gnptg N-acetylglucosamine-1-phosphate transferase subunit gamma JBrowse link NW_004936694 2,529,634 2,540,474 RGD:9068941
G Hagh hydroxyacylglutathione hydrolase JBrowse link NW_004936694 2,181,475 2,200,469 RGD:9068941
G Haghl hydroxyacylglutathione hydrolase like JBrowse link NW_004936501 286,958 290,062 RGD:9068941
G Ifng interferon gamma JBrowse link NW_004936545 6,139,130 6,144,543 RGD:7240710
G Ift140 intraflagellar transport 140 JBrowse link NW_004936694 2,344,448 2,419,396 RGD:9068941
G Igfals insulin like growth factor binding protein acid labile subunit JBrowse link NW_004936694 2,205,294 2,207,343 RGD:9068941
G Jmjd8 jumonji domain containing 8 JBrowse link NW_004936501 327,053 328,789 RGD:9068941
G Jpt2 Jupiter microtubule associated homolog 2 JBrowse link NW_004936694 2,265,360 2,283,887 RGD:9068941
G Lmf1 lipase maturation factor 1 JBrowse link NW_004936501 138,470 200,120 RGD:9068941
G LOC101964224 heparan sulfate glucosamine 3-O-sulfotransferase 6 JBrowse link NW_004936694 2,099,967 2,176,279 RGD:9068941
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link NW_004936694 2,223,020 2,263,388 RGD:9068941
G Mcrip2 MAPK regulated corepressor interacting protein 2 JBrowse link NW_004936501 360,671 365,512 RGD:9068941
G Metrn meteorin, glial cell differentiation regulator JBrowse link NW_004936501 295,970 301,344 RGD:9068941
G Mettl26 methyltransferase like 26 JBrowse link NW_004936501 368,532 371,075 RGD:9068941
G Mrps34 mitochondrial ribosomal protein S34 JBrowse link NW_004936694 2,220,492 2,221,716 RGD:9068941
G Msrb1 methionine sulfoxide reductase B1 JBrowse link NW_004936694 2,086,573 2,090,752 RGD:9068941
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 JBrowse link NW_004936694 2,073,481 2,075,989 RGD:9068941
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 JBrowse link NW_004936694 2,222,055 2,222,977 RGD:9068941
G Noxo1 NADPH oxidase organizer 1 JBrowse link NW_004936694 2,054,429 2,060,098 RGD:9068941
G Npw neuropeptide W JBrowse link NW_004936694 2,017,040 2,019,583 RGD:9068941
G Nthl1 nth like DNA glycosylase 1 JBrowse link NW_004936694 1,993,443 2,000,323 RGD:9068941
G Nubp2 nucleotide binding protein 2 JBrowse link NW_004936694 2,208,102 2,211,910 RGD:9068941
G Pigq phosphatidylinositol glycan anchor biosynthesis class Q JBrowse link NW_004936501 415,232 429,902 RGD:9068941
G Pkd1 polycystin 1, transient receptor potential channel interacting JBrowse link NW_004936694 1,923,383 1,958,160 RGD:9068941
G Ptx4 pentraxin 4 JBrowse link NW_004936694 2,435,291 2,439,837 RGD:9068941
G Rab40c RAB40C, member RAS oncogene family JBrowse link NW_004936501 375,663 409,243 RGD:9068941
G Rhbdl1 rhomboid like 1 JBrowse link NW_004936501 332,838 335,057 RGD:9068941
G Rhot2 ras homolog family member T2 JBrowse link NW_004936501 336,506 341,671 RGD:9068941
G Rnf151 ring finger protein 151 JBrowse link NW_004936694 2,066,869 2,069,537 RGD:9068941
G Rpl3l ribosomal protein L3 like JBrowse link NW_004936694 2,078,903 2,086,333 RGD:9068941
G Rps2 ribosomal protein S2 JBrowse link NW_004936694 2,071,295 2,073,409 RGD:9068941
G Rpusd1 RNA pseudouridine synthase domain containing 1 JBrowse link NW_004936501 241,190 244,180 RGD:9068941
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link NW_004936694 2,000,977 2,006,102 RGD:9068941
G Sox8 SRY-box transcription factor 8 JBrowse link NW_004936501 128,386 132,648 RGD:9068941
G Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 JBrowse link NW_004936694 2,212,022 2,217,409 RGD:9068941
G Sstr5 somatostatin receptor 5 JBrowse link NW_004936501 60,812 63,149 RGD:9068941
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link NW_004936501 328,767 330,963 RGD:9068941
G Syngr3 synaptogyrin 3 JBrowse link NW_004936694 2,043,646 2,047,897 RGD:9068941
G Tbl3 transducin beta like 3 JBrowse link NW_004936694 2,060,218 2,066,525 RGD:9068941
G Telo2 telomere maintenance 2 JBrowse link NW_004936694 2,418,223 2,433,630 RGD:9068941
G Tmem204 transmembrane protein 204 JBrowse link NW_004936694 2,382,672 2,402,798 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004936694 1,958,152 1,993,373 RGD:7240710
G Tsr3 TSR3 ribosome maturation factor JBrowse link NW_004936694 2,540,446 2,542,666 RGD:9068941
G Ube2i ubiquitin conjugating enzyme E2 I JBrowse link NW_004936694 2,561,701 2,571,284 RGD:9068941
G Unkl unk like zinc finger JBrowse link NW_004936694 2,492,102 2,529,662 RGD:9068941
G Wdr24 WD repeat domain 24 JBrowse link NW_004936501 321,877 326,984 RGD:9068941
G Wdr90 WD repeat domain 90 JBrowse link NW_004936501 342,376 359,853 RGD:9068941
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 JBrowse link NW_004936501 371,328 375,271 RGD:9068941
G Znf598 zinc finger protein 598, E3 ubiquitin ligase JBrowse link NW_004936694 2,019,714 2,035,885 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11879
    disease of cellular proliferation 5179
      Multiple Primary Neoplasms 134
        Intestinal Polyposis, with Multiple Exostoses 0
        PTEN hamartoma tumor syndrome + 26
        multiple endocrine neoplasia + 9
        tuberous sclerosis + 97
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.