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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Leukocytosis
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Accession:DOID:9001039 term browser browse the term
Definition:A transient increase in the number of leukocytes in a body fluid.
Synonyms:exact_synonym: Leukocytoses;   Pleocytoses;   Pleocytosis
 primary_id: MESH:D007964;   RDO:0004292
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Leukocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Csf3 colony stimulating factor 3 ISO associated with neoplasms; RGD PMID:18756972 RGD:11039421 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csf3r colony stimulating factor 3 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19620628 NCBI chr 5:144,031,353...144,051,966
Ensembl chr 5:144,031,402...144,051,600
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27099147, PMID:27725143 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:1884014, PMID:19633061, PMID:1581467 RGD:4142837, RGD:10450884 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO associated with Meningitis, Listeria; RGD PMID:10085034 RGD:11522759 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Itga4 integrin subunit alpha 4 IMP RGD PMID:12626659 RGD:9698418 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:5116037 RGD:11059893 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Npy5r neuropeptide Y receptor Y5 IDA RGD PMID:12417430 RGD:729324 NCBI chr16:24,796,685...24,805,730
Ensembl chr16:24,797,124...24,805,079
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
B-CELL EXPANSION WITH NFKB AND T-CELL ANERGY term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 ISO ClinVar Annotator: match by term: B-cell expansion with NFKB and T-cell anergy OMIM
ClinVar
PMID:18323416, PMID:23027925, PMID:23129749, PMID:25352053, PMID:25930198, PMID:26861442, PMID:28492532, PMID:28824638, PMID:29472930 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512
JBrowse link
Leukemoid Reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak3 Janus kinase 3 ISO ClinVar Annotator: match by term: Leukemoid Reaction ClinVar PMID:18397343, PMID:20400977, PMID:28492532 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
Monoclonal B-Cell Lymphocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amz2 archaelysin family metallopeptidase 2 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr10:97,710,905...97,721,442
Ensembl chr10:97,710,905...97,721,440
JBrowse link
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar PMID:28492532 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Dazap1 DAZ associated protein 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 7:12,289,895...12,315,897
Ensembl chr 7:12,290,402...12,311,149
JBrowse link
G Fcnb ficolin B ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 3:6,617,816...6,626,193
Ensembl chr 3:6,617,751...6,626,284
JBrowse link
G Klhl6 kelch-like family member 6 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr11:84,745,958...84,785,315
Ensembl chr11:84,745,904...84,785,893
JBrowse link
G Notch2 notch receptor 2 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar PMID:8755249, PMID:21378985, PMID:21378989, PMID:22891273, PMID:22891276, PMID:27312922, PMID:28492532 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G Sec14l1 SEC14-like lipid binding 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr10:106,065,712...106,112,859
Ensembl chr10:106,065,712...106,112,857
JBrowse link
G Slc35a5 solute carrier family 35, member A5 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr11:60,613,865...60,634,849
Ensembl chr11:60,613,882...60,634,851
JBrowse link
G Sp4 Sp4 transcription factor ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr 6:146,135,877...146,201,344
Ensembl chr 6:146,135,877...146,195,819
JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr17:9,560,735...9,565,249
Ensembl chr17:9,560,761...9,565,249
JBrowse link
G Vmp1 vacuole membrane protein 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
Monocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tet2 tet methylcytosine dioxygenase 2 ISO RGD PMID:24218139 RGD:11038772 NCBI chr 2:238,719,389...238,802,975
Ensembl chr 2:238,720,835...238,803,024
JBrowse link
Neutrophilia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:2475183 RGD:11039032 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP associated with Scorpion Stings RGD PMID:10770284 RGD:10043145 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
Persistent Polyclonal B-Cell Lymphocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 ISO DNA:missense mutations:cds:p.E127G, p.G116S (human) RGD PMID:23129749 RGD:11100033 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512
JBrowse link
transient myeloproliferative syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24056718, PMID:14636651 RGD:10450612 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Runx1 RUNX family transcription factor 1 ISO ClinVar Annotator: match by term: Transient myeloproliferative disorder of Down syndrome ClinVar PMID:10068652, PMID:12200707, PMID:15156185, PMID:22012064, PMID:23817177, PMID:28492532 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    Pathological Conditions, Signs and Symptoms 8726
      Pathologic Processes 6130
        Leukocytosis 28
          Holoprosencephaly, Recurrent Infections, and Monocytosis 0
          Leukemoid Reaction + 3
          Lymphocytosis + 13
          Monocytosis 1
          Neutrophilia 2
Path 2
Term Annotations click to browse term
  disease 16108
    disease of anatomical entity 15356
      Hemic and Lymphatic Diseases 2047
        hematopoietic system disease 1643
          leukocyte disease 498
            Leukocytosis 28
              Holoprosencephaly, Recurrent Infections, and Monocytosis 0
              Leukemoid Reaction + 3
              Lymphocytosis + 13
              Monocytosis 1
              Neutrophilia 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.