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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Asthenozoospermia
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Accession:DOID:9001513 term browser browse the term
Definition:A condition in which the percentage of motile sperm is abnormally low.
Synonyms:exact_synonym: Astheno Teratozoospermia;   Astheno Teratozoospermias;   Asthenoteratozoospermia;   Asthenoteratozoospermias
 primary_id: MESH:D053627;   RDO:0007631
For additional species annotation, visit the Alliance of Genome Resources.


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Asthenozoospermia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26181198 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
JBrowse link
G Cfap251 cilia and flagella associated protein 251 ISO ClinVar Annotator: match by term: asthenozoospermia ClinVar PMID:30122541 NCBI chr12:38,708,915...38,781,598
Ensembl chr12:38,709,595...38,782,010
JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19303595 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Plau plasminogen activator, urokinase IEP
ISO
mRNA, protein:decreased expression:testes, epididymis (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:18998460, PMID:18998460 RGD:7241809 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
oligoasthenoteratozoospermia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spata20 spermatogenesis associated 20 ISS MouseDO NCBI chr10:82,202,619...82,217,260
Ensembl chr10:82,202,605...82,209,459
JBrowse link
spermatogenic failure 7 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Catsper1 cation channel, sperm associated 1 ISO ClinVar Annotator: match by term: Spermatogenic failure 7
ClinVar Annotator: match by OMIM:612997
OMIM
ClinVar
PMID:19344877, PMID:21255775, PMID:24442342, PMID:28492532 NCBI chr 1:220,715,000...220,724,235
Ensembl chr 1:220,714,995...220,719,939
JBrowse link
G Catsper2 cation channel, sperm associated 2 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 3:113,357,361...113,379,498
Ensembl chr 3:113,357,365...113,376,751
JBrowse link
G Strc stereocilin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: SPERMATOGENIC FAILURE 7
CTD
ClinVar
PMID:24033266, PMID:25741868 NCBI chr 3:113,324,403...113,343,513
Ensembl chr 3:113,324,698...113,342,675
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16045
    disease of anatomical entity 15292
      reproductive system disease 2575
        male reproductive system disease 1774
          male infertility 177
            Asthenozoospermia 8
              oligoasthenoteratozoospermia 1
              spermatogenic failure 7 3
Path 2
Term Annotations click to browse term
  disease 16045
    disease of anatomical entity 15292
      Urogenital Diseases 4147
        Female Urogenital Diseases and Pregnancy Complications 1905
          Female Urogenital Diseases 1600
            female reproductive system disease 1596
              infertility 240
                male infertility 177
                  Asthenozoospermia 8
                    oligoasthenoteratozoospermia 1
                    spermatogenic failure 7 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.