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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Asthenozoospermia
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Accession:DOID:9001513 term browser browse the term
Definition:A condition in which the percentage of motile sperm is abnormally low.
Synonyms:exact_synonym: Astheno Teratozoospermia;   Astheno Teratozoospermias;   Asthenoteratozoospermia;   Asthenoteratozoospermias
 primary_id: MESH:D053627;   RDO:0007631
For additional species annotation, visit the Alliance of Genome Resources.


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Asthenozoospermia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BSCL2 BSCL2 lipid droplet biogenesis associated, seipin EXP CTD Direct Evidence: marker/mechanism CTD PMID:26181198 NCBI chr11:62,690,262...62,709,537
Ensembl chr11:62,690,275...62,709,845
JBrowse link
G CFAP251 cilia and flagella associated protein 251 IAGP ClinVar Annotator: match by term: asthenozoospermia ClinVar PMID:30122541 NCBI chr12:121,918,592...122,003,919
Ensembl chr12:121,918,592...122,003,927
JBrowse link
G GSTT1 glutathione S-transferase theta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19303595
G PLAU plasminogen activator, urokinase ISO
EXP
mRNA, protein:decreased expression:testes, epididymis (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:18998460, PMID:18998460 RGD:7241809 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
oligoasthenoteratozoospermia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPATA20 spermatogenesis associated 20 ISS MouseDO NCBI chr17:50,547,174...50,555,852
Ensembl chr17:50,543,058...50,555,852
JBrowse link
spermatogenic failure 7 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CATSPER1 cation channel sperm associated 1 IAGP ClinVar Annotator: match by term: SPERMATOGENIC FAILURE 7
ClinVar Annotator: match by term: Spermatogenic failure 7
ClinVar
OMIM
PMID:19344877, PMID:21255775, PMID:24442342, PMID:28492532 NCBI chr11:66,016,752...66,026,518
Ensembl chr11:66,016,752...66,026,479
JBrowse link
G CATSPER2 cation channel sperm associated 2 EXP CTD Direct Evidence: marker/mechanism CTD NCBI chr15:43,628,503...43,648,884
Ensembl chr15:43,628,503...43,668,118
JBrowse link
G STRC stereocilin EXP
IAGP
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: SPERMATOGENIC FAILURE 7
CTD
ClinVar
PMID:24033266, PMID:25741868 NCBI chr15:43,599,563...43,618,800
Ensembl chr15:43,599,563...43,618,800
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18864
    disease of anatomical entity 17349
      reproductive system disease 3233
        male reproductive system disease 2315
          male infertility 200
            Asthenozoospermia 8
              oligoasthenoteratozoospermia 1
              spermatogenic failure 7 3
Path 2
Term Annotations click to browse term
  disease 18864
    disease of anatomical entity 17349
      Urogenital Diseases 4645
        Female Urogenital Diseases and Pregnancy Complications 2080
          Female Urogenital Diseases 1759
            female reproductive system disease 1755
              infertility 255
                male infertility 200
                  Asthenozoospermia 8
                    oligoasthenoteratozoospermia 1
                    spermatogenic failure 7 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.