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ONTOLOGY REPORT - ANNOTATIONS


Term:Frontotemporal Lobar Degeneration
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Accession:DOID:9002031 term browser browse the term
Definition:Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
Synonyms:exact_synonym: FTLD;   FTLDs;   Frontotemporal Lobar Degenerations
 primary_id: MESH:D057174;   RDO:0007785
For additional species annotation, visit the Alliance of Genome Resources.


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Frontotemporal Lobar Degeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:10059351
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688397
RGD:11554173
RGD:5688712
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:5509902
RGD:9685710
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:10401634
RGD:11554173
RGD:10401650
RGD:10401647
RGD:10401638
RGD:10401637
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:10412651
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:6480505
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:11554173
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:11554173
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687136
RGD:11554173
RGD:5687172
RGD:5687159
RGD:5687158
G Tmem106b transmembrane protein 106B JBrowse link 4 39,517,679 39,534,491 RGD:11554173
amyotrophic lateral sclerosis type 14 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 15 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 22 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tuba4a tubulin, alpha 4A JBrowse link 9 82,415,599 82,419,918 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:7240710
RGD:8554872
RGD:9685712
chromosome 3-linked frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:8554872
RGD:7240710
G Pou1f1 POU class 1 homeobox 1 JBrowse link 11 2,645,659 2,662,581 RGD:8554872
frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link 7 12,742,433 12,762,423 RGD:8554872
G Arsa arylsulfatase A JBrowse link 7 130,446,644 130,452,632 RGD:8554872
G Bace2 beta-secretase 2 JBrowse link 11 37,798,397 37,880,624 RGD:13782172
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688398
RGD:8554872
RGD:11554173
RGD:5688721
RGD:5688716
G Csf1r colony stimulating factor 1 receptor JBrowse link 18 56,414,493 56,458,300 RGD:8554872
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509588
RGD:8554872
RGD:11554173
RGD:5509612
RGD:5509609
RGD:5509602
RGD:5509589
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:5508418
RGD:8554872
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:1302531
RGD:8554872
RGD:11554173
RGD:10412702
RGD:10412699
RGD:8158108
RGD:7240710
G Marchf4 membrane associated ring-CH-type finger 4 JBrowse link 9 79,781,752 79,898,726 RGD:8554872
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:8554872
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:8554872
G Mobp myelin-associated oligodendrocyte basic protein JBrowse link 8 128,824,420 128,854,492 RGD:27226701
G Pou1f1 POU class 1 homeobox 1 JBrowse link 11 2,645,659 2,662,581 RGD:8554872
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:10412726
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:7240710
RGD:8554872
RGD:11554173
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:8554872
RGD:13592920
G Tm2d3 TM2 domain containing 3 JBrowse link 1 126,573,474 126,595,778 RGD:8554872
G Tnk1 tyrosine kinase, non-receptor, 1 JBrowse link 10 56,458,650 56,475,183 RGD:8554872
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:13592920
G Vps13c vacuolar protein sorting 13 homolog C JBrowse link 8 73,682,814 73,843,290 RGD:8554872
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:8554872
frontotemporal dementia and/or amyotrophic lateral sclerosis-1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:7240710
RGD:8554872
RGD:11554173
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:8554872
frontotemporal dementia and/or amyotrophic lateral sclerosis-2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 JBrowse link 20 13,665,046 13,666,845 RGD:7240710
RGD:8554872
frontotemporal dementia and/or amyotrophic lateral sclerosis-3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:7240710
RGD:8554872
frontotemporal dementia and/or amyotrophic lateral sclerosis-4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:8554872
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:8554872
RGD:7240710
GRN-related frontotemporal lobar degeneration with TDP43 inclusions term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asb16 ankyrin repeat and SOCS box-containing 16 JBrowse link 10 90,217,979 90,224,984 RGD:8554872
G Atxn7l3 ataxin 7-like 3 JBrowse link 10 90,234,749 90,241,757 RGD:8554872
G G6pc3 glucose 6 phosphatase catalytic subunit 3 JBrowse link 10 90,134,193 90,138,425 RGD:8554872
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509604
RGD:8554872
RGD:7240710
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:8554872
G Hrob homologous recombination factor with OB-fold JBrowse link 10 90,192,608 90,214,486 RGD:8554872
G Lsm12 LSM12 homolog JBrowse link 10 90,105,562 90,127,600 RGD:8554872
G Rundc3a RUN domain containing 3A JBrowse link 10 90,342,033 90,351,172 RGD:8554872
G Slc25a39 solute carrier family 25, member 39 JBrowse link 10 90,351,899 90,356,905 RGD:8554872
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) JBrowse link 10 90,296,144 90,312,401 RGD:8554872
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:13592920
G Tmub2 transmembrane and ubiquitin-like domain containing 2 JBrowse link 10 90,230,428 90,234,874 RGD:8554872
G Ubtf upstream binding transcription factor JBrowse link 10 90,250,275 90,265,772 RGD:8554872
inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:7240710
RGD:8554872
inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:8554872
RGD:7240710
inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:7240710
RGD:8554872
inclusion body myopathy with Paget disease of bone and frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:10059681
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:11554173
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:10395280
RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10059681
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:11554173
Pick's disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:10047401
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:10047401
RGD:10047402
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:10047402
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:5509779
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:7495833
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:7240710
RGD:8554872
RGD:11554173
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:7240710
RGD:8554872
RGD:11554173
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480200
G Sncb synuclein, beta JBrowse link 17 10,384,472 10,392,776 RGD:6480200
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687194
Primary Progressive Nonfluent Aphasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15992
    Diseases of the Aged 1219
      dementia 663
        Frontotemporal Lobar Degeneration 57
          GRN-related frontotemporal lobar degeneration with TDP43 inclusions 13
          Pick Complex 0
          Primary Progressive Nonfluent Aphasia 1
          frontotemporal dementia + 52
Path 2
Term Annotations click to browse term
  disease 15992
    disease of anatomical entity 15263
      nervous system disease 10756
        central nervous system disease 8844
          brain disease 8133
            disease of mental health 5763
              cognitive disorder 1897
                dementia 663
                  Frontotemporal Lobar Degeneration 57
                    GRN-related frontotemporal lobar degeneration with TDP43 inclusions 13
                    Pick Complex 0
                    Primary Progressive Nonfluent Aphasia 1
                    frontotemporal dementia + 52
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.