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ONTOLOGY REPORT - ANNOTATIONS


Term:Hyperalgesia
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Accession:DOID:9002211 term browser browse the term
Definition:An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Synonyms:exact_synonym: Allodynia;   Allodynias, Mechanical;   Allodynias, Tactile;   Allodynias, Thermal;   Hyperalgesia, Primary;   Hyperalgesia, Secondary;   Hyperalgesia, Tactile;   Hyperalgesias;   Hyperalgesias, Mechanical;   Hyperalgesias, Primary;   Hyperalgesias, Secondary;   Hyperalgesias, Tactile;   Hyperalgesias, Thermal;   Hyperalgesic Sensations;   Mechanical Allodynia;   Mechanical Hyperalgesia;   Tactile Allodynia;   Thermal Allodynia;   Thermal Hyperalgesia;   pain hypersensitivity
 primary_id: MESH:D006930;   RDO:0005827
For additional species annotation, visit the Alliance of Genome Resources.


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Hyperalgesia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABAT 4-aminobutyrate aminotransferase JBrowse link 6 33,385,779 33,471,348 RGD:9068941
G ADK adenosine kinase JBrowse link 4 24,540,626 25,047,032 RGD:9068941
G ADM adrenomedullin JBrowse link 21 33,472,197 33,474,472 RGD:9068941
G ADORA1 adenosine A1 receptor JBrowse link 7 44,819 74,217 RGD:9068941
G ADRA1A adrenoceptor alpha 1A JBrowse link 25 30,690,959 30,801,484 RGD:9068941
G ADRA2A adrenoceptor alpha 2A JBrowse link 28 22,366,989 22,392,163 RGD:9068941
G ADRA2C adrenoceptor alpha 2C JBrowse link 3 60,608,632 60,648,112 RGD:9068941
G ADRB1 adrenoceptor beta 1 JBrowse link 28 24,908,224 24,909,684 RGD:9068941
G AGER advanced glycosylation end-product specific receptor JBrowse link 12 1,574,251 1,577,410 RGD:9068941
G AGT angiotensinogen JBrowse link 4 8,681,192 8,694,059 RGD:9068941
G AIF1 allograft inflammatory factor 1 JBrowse link 12 1,104,350 1,106,179 RGD:9068941
G AKR1B1 aldo-keto reductase family 1 member B JBrowse link 14 2,991,888 3,006,941 RGD:9068941
G ALOX12 arachidonate 12-lipoxygenase, 12S type JBrowse link 5 32,026,193 32,038,698 RGD:9068941
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 28 2,170,920 2,218,765 RGD:9068941
G ANO3 anoctamin 3 JBrowse link 21 47,046,020 47,416,360 RGD:9068941
G ANXA1 annexin A1 JBrowse link 1 84,744,159 84,763,011 RGD:9068941
G AQP4 aquaporin 4 JBrowse link 7 61,855,617 61,868,953 RGD:9068941
G AVP arginine vasopressin JBrowse link 24 18,183,057 18,184,827 RGD:9068941
G BACE1 beta-secretase 1 JBrowse link 5 16,308,953 16,319,100 RGD:9068941
G BDKRB1 bradykinin receptor B1 JBrowse link 8 65,017,655 65,028,899 RGD:9068941
G BDKRB2 bradykinin receptor B2 JBrowse link 8 64,974,588 65,005,682 RGD:9068941
G BDNF brain derived neurotrophic factor JBrowse link 21 48,191,580 48,243,699 RGD:9068941
G BECN1 beclin 1 JBrowse link 9 20,204,203 20,215,081 RGD:9068941
G C3 complement C3 JBrowse link 20 53,566,226 53,598,365 RGD:9068941
G CACNA1B calcium voltage-gated channel subunit alpha1 B JBrowse link 9 47,813,625 48,009,532 RGD:9068941
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 6 39,510,129 39,533,129 RGD:9068941
G CACNA1I calcium voltage-gated channel subunit alpha1 I JBrowse link 10 25,381,446 25,493,680 RGD:9068941
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 18 21,561,091 21,949,970 RGD:9068941
G CAMK2A calcium/calmodulin dependent protein kinase II alpha JBrowse link 4 58,800,818 58,865,830 RGD:9068941
G CAPN2 calpain 2 JBrowse link 7 40,333,379 40,367,158 RGD:9068941
G CARTPT CART prepropeptide JBrowse link 2 54,865,043 54,867,410 RGD:9068941
G CAT catalase JBrowse link 18 33,383,005 33,422,447 RGD:9068941
G CCK cholecystokinin JBrowse link 23 11,414,254 11,419,990 RGD:9068941
G CCKBR cholecystokinin B receptor JBrowse link 21 29,602,066 29,606,343 RGD:9068941
G CCL2 C-C motif chemokine ligand 2 JBrowse link 9 39,008,187 39,009,932 RGD:9068941
G CCL5 C-C motif chemokine ligand 5 JBrowse link 9 37,817,409 37,823,852 RGD:9068941
G CCR2 C-C motif chemokine receptor 2 JBrowse link 20 42,305,344 42,313,258 RGD:9068941
G CCR5 C-C motif chemokine receptor 5 JBrowse link 20 42,293,288 42,297,952 RGD:9068941
G CFL1 cofilin 1 JBrowse link 18 51,404,649 51,408,240 RGD:9068941
G CNR1 cannabinoid receptor 1 JBrowse link 12 47,537,240 47,560,723 RGD:9068941
G CNR2 cannabinoid receptor 2 JBrowse link 2 75,640,636 75,662,000 RGD:9068941
G COMT catechol-O-methyltransferase JBrowse link 26 29,359,930 29,381,854 RGD:9068941
G CRCP CGRP receptor component JBrowse link 6 806,892 843,066 RGD:9068941
G CRSP-3 calcitonin receptor-stimulating peptide 3 JBrowse link 21 37,676,841 37,680,643 RGD:9068941
G CSF3 colony stimulating factor 3 JBrowse link 9 22,529,643 22,532,326 RGD:9068941
G CSK C-terminal Src kinase JBrowse link 30 37,851,269 37,870,382 RGD:9068941
G CTSS cathepsin S JBrowse link 17 59,893,840 59,910,878 RGD:9068941
G CX3CL1 C-X3-C motif chemokine ligand 1 JBrowse link 2 59,022,794 59,032,095 RGD:9068941
G CX3CR1 C-X3-C motif chemokine receptor 1 JBrowse link 23 8,937,069 8,954,738 RGD:9068941
G CXCL12 C-X-C motif chemokine ligand 12 JBrowse link 28 2,895,916 2,903,543 RGD:9068941
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 13 62,435,035 62,438,354 RGD:9068941
G CXCR2 C-X-C motif chemokine receptor 2 JBrowse link 37 24,831,351 24,846,387 RGD:9068941
G CXCR4 C-X-C motif chemokine receptor 4 JBrowse link 19 38,874,650 38,877,740 RGD:9068941
G CYBB cytochrome b-245 beta chain JBrowse link X 32,533,365 32,568,149 RGD:9068941
G DLG4 discs large MAGUK scaffold protein 4 JBrowse link 5 32,165,399 32,175,600 RGD:9068941
G DNMT1 DNA methyltransferase 1 JBrowse link 20 50,872,213 50,928,352 RGD:9068941
G DRD3 dopamine receptor D3 JBrowse link 33 18,369,362 18,414,465 RGD:9068941
G DUSP1 dual specificity phosphatase 1 JBrowse link 4 39,588,833 39,591,065 RGD:9068941
G DUSP6 dual specificity phosphatase 6 JBrowse link 15 30,322,472 30,327,221 RGD:9068941
G EDN1 endothelin 1 JBrowse link 35 11,808,892 11,815,383 RGD:9068941
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link 13 18,586,886 18,697,339 RGD:9068941
G EP300 E1A binding protein p300 JBrowse link 10 24,076,538 24,156,708 RGD:9068941
G EPHA4 EPH receptor A4 JBrowse link 37 27,670,143 27,809,642 RGD:9068941
G EPHX2 epoxide hydrolase 2 JBrowse link 25 30,045,040 30,107,110 RGD:9068941
G ESR1 estrogen receptor 1 JBrowse link 1 42,081,952 42,368,544 RGD:9068941
G ESR2 estrogen receptor 2 JBrowse link 8 38,645,917 38,715,347 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link 18 42,782,744 42,799,531 RGD:9068941
G F2R coagulation factor II thrombin receptor JBrowse link 3 29,870,159 29,889,837 RGD:9068941
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 8 48,330,856 48,334,273 RGD:9068941
G GAL galanin and GMAP prepropeptide JBrowse link 18 49,240,437 49,246,543 RGD:9068941
G GDNF glial cell derived neurotrophic factor JBrowse link 4 70,966,694 70,991,860 RGD:9068941
G GFAP glial fibrillary acidic protein JBrowse link 9 18,569,868 18,579,463 RGD:9068941
G GFRA1 GDNF family receptor alpha 1 JBrowse link 28 26,707,592 26,910,029 RGD:9068941
G GJA1 gap junction protein alpha 1 JBrowse link 1 60,941,772 60,944,694 RGD:9068941
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 9 48,492,967 48,513,981 RGD:9068941
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 6 32,132,070 32,678,319 RGD:9068941
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 27 32,470,889 32,883,606 RGD:9068941
G GRK2 G protein-coupled receptor kinase 2 JBrowse link 18 50,148,566 50,167,422 RGD:9068941
G GRM8 glutamate metabotropic receptor 8 JBrowse link 14 8,982,180 9,719,813 RGD:9068941
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 8 36,614,045 36,656,692 RGD:9068941
G HMGB1 high mobility group box 1 JBrowse link 25 9,431,223 9,558,167 RGD:9068941
G HOXD1 homeobox D1 JBrowse link 36 19,995,326 19,997,059 RGD:9068941
G HTR2A 5-hydroxytryptamine receptor 2A JBrowse link 22 4,453,715 4,510,934 RGD:9068941
G HTR7 5-hydroxytryptamine receptor 7 JBrowse link 28 5,438,872 5,524,385 RGD:9068941
G IGF1 insulin like growth factor 1 JBrowse link 15 41,203,320 41,275,964 RGD:9068941
G IL10 interleukin 10 JBrowse link 7 5,933,285 5,937,057 RGD:9068941
G IL13 interleukin 13 JBrowse link 11 20,957,870 20,961,391 RGD:9068941
G IL17A interleukin 17A JBrowse link 12 19,854,129 19,862,521 RGD:9068941
G IL18 interleukin 18 JBrowse link 5 20,972,742 20,995,327 RGD:9068941
G IL1A interleukin 1 alpha JBrowse link 17 36,969,581 36,979,445 RGD:9068941
G IL1B interleukin 1 beta JBrowse link 17 37,019,329 37,033,388 RGD:9068941
G IL1R1 interleukin 1 receptor type 1 JBrowse link 10 40,825,986 40,897,898 RGD:9068941
G IL1RN interleukin 1 receptor antagonist JBrowse link 17 37,236,690 37,250,424 RGD:9068941
G IL2 interleukin 2 JBrowse link 19 17,750,780 17,756,394 RGD:9068941
G IL6 interleukin 6 JBrowse link 14 36,474,268 36,478,519 RGD:9068941
G IL6R interleukin 6 receptor JBrowse link 7 42,877,731 42,920,149 RGD:9068941
G INSR insulin receptor JBrowse link 20 52,017,261 52,136,061 RGD:9068941
G ITGA1 integrin subunit alpha 1 JBrowse link 4 62,287,823 62,455,940 RGD:9068941
G ITGA2 integrin subunit alpha 2 JBrowse link 4 62,170,137 62,268,962 RGD:9068941
G ITGA3 integrin subunit alpha 3 JBrowse link 9 26,065,792 26,095,649 RGD:9068941
G ITGA5 integrin subunit alpha 5 JBrowse link 27 904,892 924,757 RGD:9068941
G ITGB1 integrin subunit beta 1 JBrowse link 2 3,728,472 3,757,696 RGD:9068941
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 JBrowse link 20 12,746,171 13,065,256 RGD:9068941
G JAK2 Janus kinase 2 JBrowse link 1 93,321,055 93,438,898 RGD:9068941
G JAK3 Janus kinase 3 JBrowse link 20 45,051,135 45,068,445 RGD:9068941
G KCNC4 potassium voltage-gated channel subfamily C member 4 JBrowse link 6 41,743,214 41,764,572 RGD:9068941
G KCNK2 potassium two pore domain channel subfamily K member 2 JBrowse link 7 12,893,654 13,092,319 RGD:9068941
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 JBrowse link 13 28,765,472 29,062,371 RGD:9068941
G KMO kynurenine 3-monooxygenase JBrowse link 7 32,941,487 32,994,541 RGD:9068941
G KNG1 kininogen 1 JBrowse link 34 19,288,629 19,318,096 RGD:9068941
G LOC610380 corticotropin-releasing factor receptor 1 JBrowse link 9 9,708,696 9,763,281 RGD:9068941
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha JBrowse link 24 23,672,343 23,673,937 RGD:9068941
G MAP2K3 mitogen-activated protein kinase kinase 3 JBrowse link 5 42,732,751 42,762,420 RGD:9068941
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 26 31,013,607 31,132,998 RGD:9068941
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 6 18,109,184 18,115,728 RGD:9068941
G MAPK7 mitogen-activated protein kinase 7 JBrowse link 5 40,831,949 40,836,990 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 28 323,361 410,367 RGD:9068941
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 11 1,443,528 1,480,501 RGD:9068941
G MC1R melanocortin 1 receptor JBrowse link 5 63,694,296 63,695,249 RGD:9068941
G MC4R melanocortin 4 receptor JBrowse link 1 16,131,829 16,132,827 RGD:9068941
G MEN1 menin 1 JBrowse link 18 52,346,747 52,352,884 RGD:9068941
G MFN2 mitofusin 2 JBrowse link 2 84,284,719 84,310,715 RGD:9068941
G MIR15B microRNA mir-15b JBrowse link 34 26,460,663 26,460,722 RGD:9068941
G MIR381 microRNA mir-381 JBrowse link 8 69,274,983 69,275,057 RGD:9068941
G MIR96 microRNA mir-96 JBrowse link 14 7,068,754 7,068,842 RGD:9068941
G MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) JBrowse link 5 28,949,631 28,957,915 RGD:9068941
G MPZ myelin protein zero JBrowse link 38 21,205,339 21,210,439 RGD:9068941
G MTOR mechanistic target of rapamycin kinase JBrowse link 2 84,818,893 84,939,283 RGD:9068941
G NEFH neurofilament heavy JBrowse link 26 22,726,523 22,735,129 RGD:9068941
G NGF nerve growth factor JBrowse link 17 52,900,647 52,901,607 RGD:9068941
G NGFR nerve growth factor receptor JBrowse link 9 25,598,468 25,621,021 RGD:9068941
G NLGN2 neuroligin 2 JBrowse link 5 32,338,602 32,351,546 RGD:9068941
G NOS1 nitric oxide synthase 1 JBrowse link 26 13,787,341 13,895,176 RGD:9068941
G NOS2 nitric oxide synthase 2 JBrowse link 9 42,171,821 42,210,217 RGD:9068941
G NPY neuropeptide Y JBrowse link 14 37,824,579 37,831,289 RGD:9068941
G NRG1 neuregulin 1 JBrowse link 16 31,697,958 32,771,888 RGD:9068941
G NTF3 neurotrophin 3 JBrowse link 27 39,383,017 39,454,613 RGD:9068941
G NTRK1 neurotrophic receptor tyrosine kinase 1 JBrowse link 7 41,140,931 41,159,326 RGD:9068941
G NTRK2 neurotrophic receptor tyrosine kinase 2 JBrowse link 1 74,447,927 74,777,910 RGD:9068941
G NTSR1 neurotensin receptor 1 JBrowse link 24 46,576,690 46,615,192 RGD:9068941
G OPRK1 opioid receptor kappa 1 JBrowse link 29 5,022,270 5,054,223 RGD:9068941
G OPRL1 opioid related nociceptin receptor 1 JBrowse link 24 47,530,039 47,537,477 RGD:9068941
G OPRM1 opioid receptor mu 1 JBrowse link 1 43,972,915 44,037,477 RGD:9068941
G P2RX2 purinergic receptor P2X 2 JBrowse link 26 480,370 485,527 RGD:9068941
G P2RX3 purinergic receptor P2X 3 JBrowse link 18 38,773,930 38,801,217 RGD:9068941
G P2RY12 purinergic receptor P2Y12 JBrowse link 23 45,908,574 45,954,675 RGD:9068941
G PAWR pro-apoptotic WT1 regulator JBrowse link 15 22,114,014 22,159,287 RGD:9068941
G PDYN prodynorphin JBrowse link 24 19,043,955 19,057,413 RGD:9068941
G PENK proenkephalin JBrowse link 29 7,757,543 7,763,137 RGD:9068941
G PLA2G4A phospholipase A2 group IVA JBrowse link 7 19,804,412 19,955,215 RGD:9068941
G PNOC prepronociceptin JBrowse link 25 29,223,758 29,246,487 RGD:9068941
G PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 11 22,388,327 22,410,052 RGD:9068941
G PRKCB protein kinase C beta JBrowse link 6 21,742,970 22,064,360 RGD:9068941
G PRKCE protein kinase C epsilon JBrowse link 10 47,976,929 48,464,614 RGD:9068941
G PRKCG protein kinase C gamma JBrowse link 1 103,295,110 103,312,562 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 5 57,012,020 57,113,346 RGD:9068941
G PRKG1 protein kinase cGMP-dependent 1 JBrowse link 26 35,732,974 36,932,744 RGD:9068941
G PROKR1 prokineticin receptor 1 JBrowse link 10 67,546,502 67,557,696 RGD:9068941
G PTAFR platelet activating factor receptor JBrowse link 2 72,225,386 72,256,353 RGD:9068941
G PTGER1 prostaglandin E receptor 1 JBrowse link 20 48,156,055 48,159,838 RGD:9068941
G PTGER3 prostaglandin E receptor 3 JBrowse link 6 74,932,789 74,986,573 RGD:9068941
G PTGER4 prostaglandin E receptor 4 JBrowse link 4 68,663,362 68,676,241 RGD:9068941
G PTGES3 prostaglandin E synthase 3 JBrowse link 10 885,744 903,814 RGD:9068941
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 60,195,118 60,216,847 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 7 19,668,079 19,674,903 RGD:9068941
G PTHLH parathyroid hormone like hormone JBrowse link 27 19,781,557 19,795,078 RGD:9068941
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 20 5,892,839 5,972,672 RGD:9068941
G RGS4 regulator of G protein signaling 4 JBrowse link 38 19,771,454 19,778,917 RGD:9068941
G SCN10A sodium voltage-gated channel alpha subunit 10 JBrowse link 23 8,420,468 8,527,414 RGD:9068941
G SCN11A sodium voltage-gated channel alpha subunit 11 JBrowse link 23 8,559,804 8,651,448 RGD:9068941
G SIN3A SIN3 transcription regulator family member A JBrowse link 30 38,231,844 38,306,665 RGD:9068941
G SLC12A5 solute carrier family 12 member 5 JBrowse link 24 33,285,773 33,322,885 RGD:9068941
G SLC17A8 solute carrier family 17 member 8 JBrowse link 15 39,443,790 39,489,988 RGD:9068941
G SPARC secreted protein acidic and cysteine rich JBrowse link 4 57,659,541 57,682,147 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 9 20,539,660 20,614,631 RGD:9068941
G SYN2 synapsin II JBrowse link 20 6,368,348 6,569,355 RGD:9068941
G TAC1 tachykinin precursor 1 JBrowse link 14 22,631,106 22,640,283 RGD:9068941
G TACR1 tachykinin receptor 1 JBrowse link 17 48,038,010 48,178,971 RGD:9068941
G TGFBR1 transforming growth factor beta receptor 1 JBrowse link 11 56,191,383 56,223,042 RGD:9068941
G THBD thrombomodulin JBrowse link 24 599,773 601,649 RGD:9068941
G TLR2 toll like receptor 2 JBrowse link 15 51,454,557 51,465,429 RGD:9068941
G TLR4 toll like receptor 4 JBrowse link 11 71,356,390 71,367,166 RGD:9068941
G TNF tumor necrosis factor JBrowse link 12 1,074,561 1,076,425 RGD:9068941
G TNFRSF11B TNF receptor superfamily member 11b JBrowse link 13 18,155,765 18,183,263 RGD:9068941
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 27 38,641,837 38,654,693 RGD:9068941
G TNFRSF1B TNF receptor superfamily member 1B JBrowse link 2 84,140,179 84,151,219 RGD:9068941
G TRPA1 transient receptor potential cation channel subfamily A member 1 JBrowse link 29 20,951,736 21,000,956 RGD:9068941
G TRPC1 transient receptor potential cation channel subfamily C member 1 JBrowse link 23 38,350,066 38,416,086 RGD:9068941
G TRPC6 transient receptor potential cation channel subfamily C member 6 JBrowse link 5 29,897,378 30,007,885 RGD:9068941
G TRPV1 transient receptor potential cation channel subfamily V member 1 JBrowse link 9 47,404,987 47,443,871 RGD:9068941
G TRPV4 transient receptor potential cation channel subfamily V member 4 JBrowse link 26 17,293,334 17,330,156 RGD:9068941
G VIP vasoactive intestinal peptide JBrowse link 1 42,941,655 42,950,160 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12492
    disease of anatomical entity 12175
      nervous system disease 9901
        Neurologic Manifestations 3706
          Pain 287
            Hyperalgesia 192
Path 2
Term Annotations click to browse term
  disease 12492
    disease of anatomical entity 12175
      nervous system disease 9901
        Neurologic Manifestations 3706
          Sensation Disorders 892
            Somatosensory Disorders 307
              Hyperalgesia 192
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.