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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hyperplasia
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Accession:DOID:9002221 term browser browse the term
Definition:An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Synonyms:exact_synonym: Hyperplasias
 primary_id: MESH:D006965;   RDO:0001143
 xref: NCI:C3113
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Hyperplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO associated with Hyperinsulinism;DNA:missense mutations:exon:p.R1353P, p.R1421C, p.R1494W (human) RGD PMID:9769320 RGD:2325205 NCBI chr 1:102,110,708...102,191,287
Ensembl chr 1:102,110,708...102,191,287
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:14742740 RGD:2325255 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20530298 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:17596282 RGD:2317191 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 IDA RGD PMID:12555267 RGD:704377 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO RGD PMID:7569956 RGD:734632 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:11889595 RGD:2293156 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brd4 bromodomain containing 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25242322 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Cav1 caveolin 1 ISO RGD PMID:12368209 RGD:8661765 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccnb1 cyclin B1 IEP mRNA, protein:increased expression:thyroid gland RGD PMID:19298605 RGD:2314685 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12151359, PMID:21541686 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25a cell division cycle 25A ISO RGD PMID:17283130 RGD:2764000 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEP protein:increased expression RGD PMID:23890812 RGD:13792775 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A treatment IEP RGD PMID:23427405 RGD:8552677 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Clu clusterin ISO associated with Breast Diseases RGD PMID:10934144 RGD:8699513 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col2a1 collagen type II alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25481498 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Csk C-terminal Src kinase IEP mRNA, protein:decreased expression:large intestine mucosa RGD PMID:15961079 RGD:5134365 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Egfr epidermal growth factor receptor IEP protein:increased expression:carotid artery (rat) RGD PMID:21357274 RGD:5131466 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Glp1r glucagon-like peptide 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23471186 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19234301 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20864298 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IMP RGD PMID:15939736 RGD:7495757 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il13 interleukin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19342650 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il9 interleukin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19342650 NCBI chr17:8,558,827...8,561,950
Ensembl chr17:8,558,827...8,561,950
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:23291559 NCBI chr19:58,823,836...58,862,926
Ensembl chr19:58,823,814...58,862,926
JBrowse link
G Kdm1a lysine demethylase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22493729 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Ldlr low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9207284 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27712037 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22561872 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
JBrowse link
G Mat1a methionine adenosyltransferase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12060674 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
JBrowse link
G Mmp1 matrix metallopeptidase 1 IDA Intimal Hyperplasia RGD PMID:22860019 RGD:7207219 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP protein:increased expression:serum RGD PMID:19726059 RGD:2325718 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15728660 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25174395 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19234301 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19336973 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase IEP protein:increased expression:lung, alveolus (rat) RGD PMID:11742033 RGD:6483575 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:22729222, PMID:22214849 RGD:13207413 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Prg4 proteoglycan 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10545950 NCBI chr13:67,672,588...67,688,902
Ensembl chr13:67,672,878...67,688,477
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12151359, PMID:17093206, PMID:22561872 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rln3 relaxin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:16112403 NCBI chr19:25,164,497...25,166,528
Ensembl chr19:25,164,497...25,166,528
JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21383188 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20172950 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEP mRNA:increased expression:bile duct, duct epithelial cell RGD PMID:12632524 RGD:1299231 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Breast Diseases;protein:increased expression:breast RGD PMID:19623180 RGD:2315458 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Zfp36 zinc finger protein 36 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15944294 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
Epidermal Hyperplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO RGD PMID:18208974 RGD:8695988 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 ISO human gene in a mouse model RGD PMID:24440982 RGD:11039481 NCBI chr 3:159,305,345...159,310,668
Ensembl chr 3:159,305,345...159,310,668
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:23870655 RGD:8699499 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
Hypoinsulinemic Hypoglycemia with Hemihypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 ISO ClinVar Annotator: match by term: Hypoinsulinemic hypoglycemia and hemihypertrophy OMIM
ClinVar
PMID:21979934 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
Intimal Hyperplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 ISO associated with Vascular System Injuries; RGD PMID:20836883 RGD:8661636
G Cdk2 cyclin dependent kinase 2 treatment ISO RGD PMID:8104336 RGD:10448975 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:20836883 RGD:8661636 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Egr1 early growth response 1 treatment IMP RGD PMID:23774133 RGD:10395302 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:15662024 RGD:10402197 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:9118520 RGD:11520787 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Klf5 Kruppel-like factor 5 IEP RGD PMID:11120052 RGD:1581748 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Mdm2 MDM2 proto-oncogene treatment ISO RGD PMID:21498419 RGD:10412065 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mmp7 matrix metallopeptidase 7 IEP RGD PMID:20098355 RGD:9685369 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO RGD PMID:9576106 RGD:11534002 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pcna proliferating cell nuclear antigen treatment IMP RGD PMID:8104336 RGD:10448975 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdgfd platelet derived growth factor D IEP protein:increased expression:smooth muscle cell: RGD PMID:15752751 RGD:9854640 NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IMP RGD PMID:10982551 RGD:10449504 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
Neointima term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment ISO RGD PMID:24132651 RGD:8695998 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19258495, PMID:29609002 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment ISO RGD PMID:23535897 RGD:13782090 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20671235 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Axl Axl receptor tyrosine kinase IEP RGD PMID:9758639 RGD:631894 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Becn1 beclin 1 IMP RGD PMID:25238224 RGD:11558011 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Clu clusterin ISO RGD PMID:19696405, PMID:20032585 RGD:8699512, RGD:9068412 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cybb cytochrome b-245 beta chain treatment IMP RGD PMID:20485380 RGD:11040762 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Drd4 dopamine receptor D4 treatment IDA associated with type 2 diabetes mellitus RGD PMID:24888351 RGD:13506962 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Ece1 endothelin converting enzyme 1 IEP mRNA:increased expression:carotid artery RGD PMID:8575076 RGD:7244170 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 treatment ISO RGD PMID:18485080 RGD:9685444 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Epc1 enhancer of polycomb homolog 1 treatment ISO RGD PMID:22398275 RGD:9587795 NCBI chr17:57,303,968...57,394,975
Ensembl chr17:57,304,933...57,394,985
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP RGD PMID:17438359 RGD:2289992 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G F3 coagulation factor III, tissue factor treatment IEP RGD PMID:22140576 RGD:11341672 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf2 fibroblast growth factor 2 IEP RGD PMID:8808969 RGD:8655643 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IDA RGD PMID:15072997 RGD:10402089 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 treatment IEP
IMP
mRNA,protein:increased expression:smooth muscle cell: RGD PMID:9400373, PMID:22814749 RGD:10402128, RGD:10402146 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Foxo4 forkhead box O4 ISO protein:increased expression:smooth muscle cell: RGD PMID:17242183, PMID:16054032 RGD:10402361, RGD:10402362 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158
JBrowse link
G Gas6 growth arrest specific 6 IEP RGD PMID:9758639 RGD:631894 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Hmox1 heme oxygenase 1 treatment IMP RGD PMID:21804207 RGD:10755571 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 ISO associated with Hypertension RGD PMID:12791939 RGD:1580477 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO associated with Vascular System Injuries RGD PMID:23657573 RGD:11049552 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Klf5 Kruppel-like factor 5 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:16224062, PMID:10417400 RGD:1581746 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Lgals3 galectin 3 IEP mRNA:increased expression:thoracic aorta RGD PMID:9688561 RGD:9685205 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IMP RGD PMID:14638553 RGD:10412321 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mir125a microRNA 125a treatment IMP RGD PMID:30156956 RGD:26884369 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD PMID:17964422, PMID:23344254 RGD:13207403 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD PMID:17964422, PMID:23344254 RGD:13207403 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myb MYB proto-oncogene, transcription factor treatment IMP RGD PMID:10438864 RGD:11532744 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 IMP RGD PMID:22508052 RGD:11073699 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nrg1 neuregulin 1 IEP RGD PMID:17438359 RGD:2289992 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IDA
IMP
RGD PMID:22922962, PMID:19359598 RGD:10041068, RGD:11533945 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP RGD PMID:15044192 RGD:10413907 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP RGD PMID:8585266 RGD:10449489 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:20307651 RGD:8693429 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP associated with Carotid Artery Injuries RGD PMID:22922962 RGD:10041068 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29609002 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Selp selectin P treatment IMP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Senp1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245
JBrowse link
G Serpine1 serpin family E member 1 treatment IMP
ISO
associated with Diabetes Mellitus, Type 2
human protein in rat model
RGD PMID:18091579, PMID:19574558 RGD:8547879, RGD:8547913 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Ssh1 slingshot protein phosphatase 1 IEP protein:increased expression:carotid artery RGD PMID:21868701 RGD:11535005 NCBI chr12:48,403,184...48,447,964
Ensembl chr12:48,403,797...48,446,977
JBrowse link
G Stat4 signal transducer and activator of transcription 4 treatment IDA associated with Carotid Artery Injuries RGD PMID:16118253 RGD:5509614 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO
IEP
RGD PMID:10521388, PMID:22140576 RGD:11060274, RGD:11341672 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:16186389 RGD:13463598 NCBI chr12:2,517,006...2,533,707
Ensembl chr12:2,517,006...2,533,706
JBrowse link
G Yy1 YY1 transcription factor treatment IMP RGD PMID:21030713 RGD:9588268 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link
PINEAL HYPERPLASIA, INSULIN-RESISTANT DIABETES MELLITUS, AND SOMATIC ABNORMALITIES term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO ClinVar Annotator: match by term: Pineal hyperplasia AND diabetes mellitus syndrome
ClinVar Annotator: match by term: Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, and Somatic Abnormalities
ClinVar
OMIM
PMID:2002058, PMID:2121734, PMID:2211730, PMID:2233914, PMID:2365819, PMID:2983222, PMID:3721065, PMID:7657032, PMID:8257688, PMID:8314008, PMID:8432414, PMID:8900242, PMID:9249867, PMID:9449692, PMID:10084586, PMID:10933564, PMID:11463381, PMID:19135752, PMID:22775283, PMID:23969187, PMID:24033266, PMID:25358339, PMID:25741868, PMID:26691667, PMID:27896077, PMID:28492532, PMID:29082893 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16045
    Pathological Conditions, Signs and Symptoms 8735
      Pathologic Processes 6121
        Hyperplasia 116
          Epidermal Hyperplasia 3
          Facial Hemihypertrophy + 1
          Hemihyperplasia, Isolated 0
          Intimal Hyperplasia + 60
          PINEAL HYPERPLASIA, INSULIN-RESISTANT DIABETES MELLITUS, AND SOMATIC ABNORMALITIES 1
          Pseudoangiomatous Stromal Hyperplasia 0
          Sebaceous Gland Hyperplasia, Familial Presenile 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.