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ONTOLOGY REPORT - ANNOTATIONS


Term:Shy-Drager Syndrome
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Accession:DOID:9002322 term browser browse the term
Definition:A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
Synonyms:exact_synonym: Dysautonomia Orthostatic Hypotension Syndrome;   Dysautonomic Orthostatic Hypotension;   Dysautonomic Orthostatic Hypotensions;   Idiopathic Orthostatic Hypotension, Shy Drager Type;   Progressive Autonomic Failure;   dysautonomia-orthostatic hypotension syndromes;   progressive autonomic failures
 primary_id: MESH:D012791
 alt_id: RDO:0006570
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Shy-Drager Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:11554173
G Coq2 coenzyme Q2, polyprenyltransferase JBrowse link 14 10,581,102 10,601,093 RGD:8554872
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15619
    syndrome 5154
      multiple system atrophy 29
        Shy-Drager Syndrome 3
Path 2
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  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        central nervous system disease 8092
          brain disease 7561
            movement disease 1000
              multiple system atrophy 29
                Shy-Drager Syndrome 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.