ONTOLOGY REPORT - ANNOTATIONS


Term:Knee Osteoarthritis
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Accession:DOID:9002331 term browser browse the term
Definition:Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Synonyms:exact_synonym: Knee Osteoarthritides;   osteoarthritis of knee;   osteoarthritis of knees
 primary_id: MESH:D020370
 alt_id: RDO:0007403
For additional species annotation, visit the Alliance of Genome Resources.


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Knee Osteoarthritis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:10053727
G Anxa5 annexin A5 JBrowse link 2 123,162,477 123,194,730 RGD:10053727
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:10043199
G Aspn asporin JBrowse link 17 14,655,958 14,681,355 RGD:9684965
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:6482710
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907382
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6907382
G Bglap bone gamma-carboxyglutamate protein JBrowse link 2 187,741,770 187,748,445 RGD:6483563
RGD:6483595
G Ccr2 C-C motif chemokine receptor 2 RGD:8661785
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6893494
RGD:6893565
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:10395278
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:10045662
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 1 164,113,459 164,143,818 RGD:6893494
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:6907382
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 JBrowse link 8 85,838,594 85,841,816 RGD:13506963
G Efemp1 EGF containing fibulin extracellular matrix protein 1 JBrowse link 14 113,202,382 113,294,993 RGD:10401792
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:10395367
RGD:10395368
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10400892
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:10043199
RGD:10045840
RGD:10045835
RGD:10045829
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:10043199
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:5147774
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:11568056
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:11554173
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:10401830
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:10402061
RGD:10402184
G Hmgb2 high mobility group box 2 JBrowse link 16 36,077,615 36,080,191 RGD:10402184
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:10412655
RGD:10429075
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:10045862
RGD:10003130
RGD:10046057
RGD:10045868
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:10045874
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:10045944
RGD:10046057
RGD:10045946
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:5687147
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:2317291
RGD:10402787
G Kl Klotho JBrowse link 12 942,974 987,206 RGD:10403041
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:10411887
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:10411887
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:10054291
G Ltbp1 latent transforming growth factor beta binding protein 1 JBrowse link 6 21,203,502 21,600,441 RGD:11554173
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:8549737
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:8694098
G Penk proenkephalin JBrowse link 5 17,056,412 17,061,762 RGD:10003115
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:2300093
G Sbno1 strawberry notch homolog 1 JBrowse link 12 37,593,692 37,650,761 RGD:11554173
G Slc26a2 solute carrier family 26 member 2 JBrowse link 18 56,518,999 56,534,539 RGD:13208866
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:2317486
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:1331525
G Wwp2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 19 39,543,246 39,614,624 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14919
    Diseases of the Aged 1162
      osteoarthritis 220
        Knee Osteoarthritis 46
Path 2
Term Annotations click to browse term
  disease 14919
    disease of anatomical entity 14083
      Immune & Inflammatory Diseases 3002
        immune system disease 2424
          hypersensitivity reaction disease 1464
            autoimmune hypersensitivity disease 1169
              autoimmune disease of musculoskeletal system 823
                rheumatic disease 810
                  osteoarthritis 220
                    Knee Osteoarthritis 46
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.