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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Experimental Arthritis
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Accession:DOID:9002457 term browser browse the term
Definition:ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
Synonyms:exact_synonym: Adjuvant Arthritis;   Arthritis, Adjuvant-Induced;   Collagen Arthritides;   Collagen Arthritis;   Collagen-Induced Arthritides;   Collagen-Induced Arthritis
 primary_id: MESH:D001169
 alt_id: RDO:0004914
For additional species annotation, visit the Alliance of Genome Resources.


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Experimental Arthritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEP protein:increased expression:serum RGD PMID:6163339 RGD:10046032 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A IEP
ISO
mRNA:altered expression:liver
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:intestinal mucosa (rat)
CTD PMID:17827786, PMID:19152228, PMID:17827786 RGD:2315573, RGD:11040994 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 IEP mRNA:decreased expression:kidney RGD PMID:22974786 RGD:11038789 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 IEP mRNA:decreased expression:small intestine RGD PMID:19152228 RGD:2315573 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acan aggrecan treatment IEP RGD PMID:25821409 RGD:12879456 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Ace angiotensin I converting enzyme IEP RGD PMID:20213806 RGD:2325221 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18988084 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18988084 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18988084 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 IEP RGD PMID:23897050 RGD:13703039 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 IEP RGD PMID:23897050 RGD:13703039 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IEP
ISO
protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:23326410, PMID:21681567, PMID:19026984 RGD:5685385, RGD:5686814 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adk adenosine kinase IMP RGD PMID:11160636 RGD:6482663 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Ahcy adenosylhomocysteinase IDA RGD PMID:11123369 RGD:1598898 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25194622 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment IDA RGD PMID:22391142 RGD:10041007 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:20472598 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO RGD PMID:19675173 RGD:5509599 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Anxa1 annexin A1 IMP
ISO
RGD PMID:10403283, PMID:23267026 RGD:2306928, RGD:7421573 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Aoc3 amine oxidase, copper containing 3 IMP RGD PMID:16947396 RGD:2313925 NCBI chr10:89,251,370...89,259,313
Ensembl chr10:89,251,370...89,259,313
JBrowse link
G Apoa4 apolipoprotein A4 IEP protein:decreased expression:blood serum (rat) RGD PMID:10892728 RGD:5685694 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Arrb1 arrestin, beta 1 IEP protein:increased expression:knee, synoviocyte (rat) RGD PMID:20965243 RGD:5509895 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 IEP protein:increased expression:knee, synoviocyte (rat) RGD PMID:20965243 RGD:5509895 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IMP RGD PMID:17408934 RGD:5144054 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:21199477, PMID:22978269 RGD:10054249, RGD:10054498 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:21199477, PMID:22978269 RGD:10054249, RGD:10054498 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:15001555 RGD:1625760 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO protein:decreased expression:serum RGD PMID:21406003 RGD:6483549 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Btk Bruton tyrosine kinase treatment IMP RGD PMID:22228807 RGD:11040701 NCBI chr  X:105,360,922...105,390,580
Ensembl chr  X:105,360,922...105,390,580
JBrowse link
G C3 complement C3 treatment ISO
IDA
RGD PMID:20051658, PMID:7347767 RGD:7411688, RGD:11041098 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C5 complement C5 ISO
IMP
RGD PMID:20975959, PMID:12355496 RGD:5130175, RGD:1600637 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Cabin1 calcineurin binding protein 1 ISO RGD PMID:22275266 RGD:10054391 NCBI chr20:13,836,032...13,963,003
Ensembl chr20:13,836,030...13,963,003
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16690336 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbl Cbl proto-oncogene treatment IDA RGD PMID:16984225 RGD:2306289 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cblb Cbl proto-oncogene B IMP RGD PMID:16984225 RGD:2306289 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IMP
IDA
IEP
mRNA, protein:increased expression:synovium RGD PMID:18292571, PMID:24583103, PMID:18726678, PMID:17052673 RGD:2307052, RGD:11526142, RGD:2307008, RGD:2307143 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 IEP mRNA, protein:increased expression:synovium, monocytes RGD PMID:17052673 RGD:2307143 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IMP
IEP
mRNA, protein:increased expression:synovium, monocytes RGD PMID:9637726, PMID:17052673 RGD:4889940, RGD:2307143 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 onset ISO RGD PMID:17178563 RGD:6483780 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ISO
IEP
RGD PMID:18608173, PMID:14674010 RGD:5688144, RGD:1582346 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IEP RGD PMID:16320322 RGD:4144893
G Ccr5 C-C motif chemokine receptor 5 treatment IEP mRNA:increased expression:ankle (rat) RGD PMID:14674010, PMID:22289897 RGD:1582346, RGD:5687744 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd28 Cd28 molecule IEP RGD PMID:18601859 RGD:2307202 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd4 Cd4 molecule treatment ISO
IMP
RGD PMID:15479897, PMID:12010568 RGD:10058957, RGD:10058960 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176
JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:20435931 RGD:5490544 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand treatment IDA
ISO
IEP
protein:increased expression:plasma (rat) RGD PMID:27218142, PMID:7689748, PMID:22611405 RGD:11344958, RGD:11352696, RGD:11352298 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd44 CD44 molecule (Indian blood group) IEP protein:increased expression:joint, macrophage, lymphocyte RGD PMID:8639178 RGD:2289388 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd46 CD46 molecule ISO RGD PMID:21852528 RGD:6483461 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Cd59 CD59 molecule IDA RGD PMID:14519760 RGD:1600483 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd69 Cd69 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:12882836 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cd80 Cd80 molecule ISO RGD PMID:22004797 RGD:6902903 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cdc42 cell division cycle 42 ISO protein:increased activation:bone marrow, macrophage RGD PMID:21266780 RGD:5688271 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A treatment ISO RGD PMID:10395320 RGD:8552686 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cfh complement factor H ISO RGD PMID:19828624 RGD:5684557 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Col2a1 collagen type II alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:16200597, PMID:21188452, PMID:23326410, PMID:24709313, PMID:25194622, PMID:25481498, PMID:26070417, PMID:29908986, PMID:29935983 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cp ceruloplasmin IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:19330884, PMID:19205849 RGD:2314686 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpox coproporphyrinogen oxidase IEP protein:decreased activity:liver (rat) RGD PMID:9173682 RGD:1600958 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:17550594 RGD:1626231 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19330884 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:12742377 RGD:11039465 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csk C-terminal Src kinase IMP RGD PMID:10411542 RGD:5134371 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 treatment IMP
ISO
RGD PMID:22354915, PMID:7543497 RGD:7204500, RGD:7204519 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Ctsb cathepsin B IEP mRNA:increased expression:knee joint, synovium (rat) RGD PMID:17195213 RGD:2315521 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsk cathepsin K IEP mRNA:increased expression:synovium, bone marrow RGD PMID:15353610 RGD:1601025 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Ctss cathepsin S ISO RGD PMID:21439785 RGD:5686915 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP RGD PMID:11465708 RGD:4892002 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP protein:increased expression:spinal cord RGD PMID:17123734, PMID:11465708 RGD:4891969, RGD:4892002 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP RGD PMID:19096963 RGD:4889415 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 severity IMP RGD PMID:10358204 RGD:5135272 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) IMP RGD PMID:15182735 RGD:2316231 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25194984 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Drd1 dopamine receptor D1 treatment IEP
IDA
mRNA:increased expression:corpus striatum (rat) RGD PMID:23762129, PMID:23762129 RGD:7248592, RGD:7248592 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 treatment IEP
IDA
mRNA:increased expression:corpus striatum (rat) RGD PMID:23762129, PMID:23762129 RGD:7248592, RGD:7248592 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Edn1 endothelin 1 ISO mRNA:increased expression:inguinal lymph node (mouse) RGD PMID:22249931 RGD:8661695 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor ISO CTD Direct Evidence: therapeutic CTD PMID:7589090 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 treatment ISO associated with Osteoporosis RGD PMID:20112355 RGD:10045851 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 IDA RGD PMID:16269464 RGD:5508854 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F2 coagulation factor II ISO RGD PMID:21436072 RGD:5147764 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F2r coagulation factor II (thrombin) receptor severity ISO RGD PMID:19674841 RGD:7387269 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO RGD PMID:12511586 RGD:735010 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Faslg Fas ligand treatment IMP RGD PMID:22354915 RGD:7204500 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia ISO CTD Direct Evidence: marker/mechanism CTD PMID:12875993, PMID:16670289 RGD:9685708 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa onset ISO RGD PMID:18354234, PMID:16623928 RGD:5508446, RGD:5508457 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb ISO RGD PMID:23341540 RGD:11344930 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fgf8 fibroblast growth factor 8 IMP RGD PMID:18699993 RGD:2314157 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:22833219 RGD:10402072 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO RGD PMID:19180491 RGD:6483591 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 IAGP RGD PMID:10857786 RGD:61066 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Foxp3 forkhead box P3 treatment IEP mRNA,protein:decreased expression:lung RGD PMID:29264841, PMID:23643080 RGD:38549364, RGD:38599003 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gja1 gap junction protein, alpha 1 IMP RGD PMID:23165424 RGD:7207259 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gli1 GLI family zinc finger 1 treatment IEP RGD PMID:25821409 RGD:12879456 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gpi glucose-6-phosphate isomerase ISO RGD PMID:23911657 RGD:11051957 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 disease_progression
treatment
IEP protein:increased expression:aorta (rat)
protein:altered expression:T cell (rat)
RGD PMID:28653218, PMID:28349925, PMID:28631356 RGD:13513975, RGD:13513979, RGD:13513976 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grn granulin precursor ISO RGD PMID:21393509 RGD:5509782 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16713974 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 IEP mRNA,protein:altered expression:bone: RGD PMID:25264706 RGD:9686117 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Hdac6 histone deacetylase 6 treatment ISO RGD PMID:23541634 RGD:9681550 NCBI chr  X:15,295,372...15,316,673
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment IDA RGD PMID:21679445 RGD:8693318 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 IEP protein:altered localization:cytoplasm, extracellular matrix RGD PMID:12384917 RGD:728698 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:17119970 RGD:5508468 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hp haptoglobin IEP mRNA, protein:increased expression:tendon, ankle
protein:increased expression:serum
RGD PMID:12801280, PMID:15899029 RGD:1626375, RGD:1626370 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IDA RGD PMID:15529360, PMID:10882416 RGD:1624244, RGD:12910542 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Ifng interferon gamma IMP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:19203382, PMID:22450443, PMID:12412757, PMID:7774621 RGD:2311498, RGD:10755750 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 IEP protein:decreased expression:plasma RGD PMID:19246225 RGD:2306697 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IEP mRNA, protein:increased expression:kidney, serum RGD PMID:14642797 RGD:10402760 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO
IMP
RGD PMID:21087862, PMID:19652024 RGD:7495772, RGD:7495778 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma treatment IDA RGD PMID:16684367 RGD:12791276 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Il10 interleukin 10 treatment IEP
ISO
IDA
CTD Direct Evidence: marker/mechanism|therapeutic
protein:decreased expression:serum:
CTD PMID:20974942, PMID:22450443, PMID:19193354, PMID:19169271, PMID:23140046, PMID:22052031, PMID:15270736 RGD:2311059, RGD:8662976, RGD:7193038, RGD:7364838, RGD:1626677 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 treatment ISO
IMP
CTD Direct Evidence: therapeutic CTD PMID:10444273, PMID:17665443, PMID:11860705 RGD:4889497, RGD:8549606 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:20188418 RGD:5000761 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il17a interleukin 17A treatment IMP
ISO
IEP
IDA
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)
CTD PMID:20974942, PMID:20925596, PMID:23377547, PMID:21194185, PMID:20925596 RGD:4781444, RGD:9130803, RGD:9068936, RGD:4781444 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 disease_progression IEP
IMP
RGD PMID:19096963, PMID:15147345 RGD:4889415, RGD:4889503 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha IDA
IEP
protein:increased expression:serum: RGD PMID:20379758, PMID:19169271 RGD:6907373, RGD:8662976 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta treatment IDA
IEP
ISO
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum (rat)
CTD PMID:19330884, PMID:20131233, PMID:20974942, PMID:22450443, PMID:21557995, PMID:29408684, PMID:24028507, PMID:23140046 RGD:7175317, RGD:13792834, RGD:10755447, RGD:7193038 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20472598 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO
IEP
rat model treated with human protein
human gene in a rat model
mRNA:increased expression:popliteal lymph node (rat)
mouse model treated with human protein
RGD PMID:15270736, PMID:12727108, PMID:10921508, PMID:22267332, PMID:23006786 RGD:1626677, RGD:8551745, RGD:8551741, RGD:8549801, RGD:6907376 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 treatment IEP
IDA
protein:increased expression:serum: RGD PMID:19169271, PMID:2492102 RGD:8662976, RGD:10047055 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il20 interleukin 20 IMP RGD PMID:20722035 RGD:5147393 NCBI chr13:47,644,071...47,651,487
Ensembl chr13:47,644,071...47,647,715
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha IDA RGD PMID:17928458 RGD:2325988 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il33 interleukin 33 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20472598 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 treatment IMP
ISO
IEP
CTD Direct Evidence: therapeutic CTD PMID:10444273, PMID:16869003, PMID:23972727, PMID:23140046 RGD:2317300, RGD:10402790, RGD:7193038 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 treatment IEP
ISO
IDA
IMP
CTD Direct Evidence: marker/mechanism CTD PMID:20131233, PMID:20974942, PMID:22450443, PMID:24028507, PMID:8607900, PMID:10381487, PMID:23503893 RGD:10755447, RGD:11060267, RGD:11049553, RGD:11049551 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 signal transducer ISO RGD PMID:20626857 RGD:5509945 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Itga4 integrin subunit alpha 4 treatment IMP RGD PMID:12969328 RGD:9698440 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itgb2 integrin subunit beta 2 IMP RGD PMID:8881759 RGD:6482229 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itgb3 integrin subunit beta 3 IMP protein:increased expression:endothelial cell RGD PMID:16869003 RGD:2317300 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO RGD PMID:19265135 RGD:6482234 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jak1 Janus kinase 1 treatment IMP RGD PMID:29452839 RGD:19165139 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jak2 Janus kinase 2 treatment ISO
IDA
RGD PMID:22339472, PMID:23711144, PMID:22800927 RGD:10403066, RGD:10403081, RGD:10403074 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jak3 Janus kinase 3 treatment IMP
IEP
RGD PMID:25762693, PMID:18234077, PMID:21434883 RGD:11533938, RGD:11533944, RGD:11533942 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Klkb1 kallikrein B1 IMP
IEP
RGD PMID:22739815, PMID:9783057 RGD:7297047, RGD:7327138 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Kng2 kininogen 2 IEP peptidoglycan-polysaccharide-induced arthritis in Lewis rats RGD PMID:9214434, PMID:1996642 RGD:1600547, RGD:11059895 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kyat1 kynurenine aminotransferase 1 IMP RGD PMID:16984225 RGD:2306289 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15142272 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lgals3 galectin 3 IEP RGD PMID:16507131 RGD:1625684 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:16331767 RGD:10412332 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mif macrophage migration inhibitory factor IDA RGD PMID:10765927 RGD:1642012 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mir152 microRNA 152 ISO
IEP
CTD Direct Evidence: marker/mechanism
miRNA:decreased exression:synovial membrane of synovial joint
CTD PMID:25194984, PMID:25194984 RGD:21066343 NCBI chr10:84,719,319...84,719,403
Ensembl chr10:84,719,319...84,719,403
JBrowse link
G Mir26a microRNA 26a EXP CTD Direct Evidence: therapeutic CTD PMID:24423102 NCBI chr 8:127,714,441...127,714,530
Ensembl chr 8:127,714,441...127,714,530
JBrowse link
G Mmp1 matrix metallopeptidase 1 IDA
IEP
RGD PMID:21288455, PMID:24011916, PMID:21108488 RGD:7207362, RGD:8549748, RGD:7207365 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp13 matrix metallopeptidase 13 treatment IEP
IDA
RGD PMID:24244039, PMID:11435459 RGD:8694124, RGD:1582329 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:ankle joint
CTD PMID:20974942, PMID:20703013, PMID:24244039, PMID:24244039, PMID:24011916, PMID:21679445 RGD:7241231, RGD:8694124, RGD:8694124, RGD:8549748, RGD:8693318 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP protein:increased expression:cartilage, serum, synovial fluid RGD PMID:17463159 RGD:1642035 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22450443 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 susceptibility ISO DNA:transversion: :m.7778G>T (mouse) RGD PMID:19759059 RGD:5490297 NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IEP RGD PMID:22391142 RGD:10041007 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO RGD PMID:20131263 RGD:8552884 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Myod1 myogenic differentiation 1 treatment IEP RGD PMID:23781298 RGD:9686078 NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248
JBrowse link
G Myog myogenin treatment IDA RGD PMID:23781298 RGD:9686078 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 severity IAGP DNA:missense mutations:cds:p.M106V, p.M153T (rat) RGD PMID:12461526 RGD:628543 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO RGD PMID:21424514, PMID:20131263 RGD:5508728, RGD:8552884 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Nos2 nitric oxide synthase 2 IMP
ISO
protein:increased expression:ankle joint (mouse) RGD PMID:12826065, PMID:21880869 RGD:1358527, RGD:5509060 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29337196 RGD:13504725 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npsr1 neuropeptide S receptor 1 treatment IMP RGD PMID:24884567 RGD:9831205 NCBI chr 8:25,246,174...25,483,582
Ensembl chr 8:25,246,292...25,482,647
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 severity ISO RGD PMID:16905546 RGD:11073695 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 ISO RGD PMID:21859686 RGD:6480864 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ISO RGD PMID:21859686 RGD:6480864 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nras NRAS proto-oncogene, GTPase IEP RGD PMID:18706093 RGD:2300006 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Nts neurotensin IEP RGD PMID:8518953 RGD:9743903 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Orm1 orosomucoid 1 IEP protein:increased expression:liver RGD PMID:16166348 RGD:2316639 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G P2ry12 purinergic receptor P2Y12 IMP RGD PMID:22028806 RGD:6480518 NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase IDA RGD PMID:17138865 RGD:6483527 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 severity ISO RGD PMID:16356201 RGD:5684009 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 severity ISO protein:increased expression:knee joint, blood vessels (mouse) RGD PMID:22548760, PMID:14613294, PMID:21982514 RGD:6484738, RGD:6771222, RGD:6771177 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pgf placental growth factor ISO RGD PMID:19180491 RGD:6483591 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO RGD PMID:18412166 RGD:6482696 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO RGD PMID:20374644, PMID:18412166 RGD:6482684, RGD:6482696 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:20973954 RGD:6483801 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Ptch1 patched 1 treatment IEP RGD PMID:25821409 RGD:12879456 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Ptger4 prostaglandin E receptor 4 treatment
disease_progression
ISO
IEP
IMP
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:tarsal joint, synovium (rat)
CTD PMID:18287210, PMID:20423341, PMID:11207665, PMID:18287210 RGD:10003041, RGD:10043377, RGD:10003052 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptges prostaglandin E synthase IEP mRNA, protein:increased expression:paw RGD PMID:12707354 RGD:2300108 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptges3 prostaglandin E synthase 3 IEP mRNA:increased expression:paw (rat) RGD PMID:12707354 RGD:2300108 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEP mRNA, protein:increased expression:synovium RGD PMID:22289897 RGD:5687744 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
IEP
ISO
mRNA, protein:increased expression:synovium
protein:increased expression:autopod joint
RGD PMID:18758904, PMID:22289897, PMID:21765105 RGD:2300221, RGD:5687744, RGD:5508310 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 IEP protein:increased expression:metatarsophalangeal joint, mononuclear cell (rat) RGD PMID:24998229 RGD:11532752 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Rag2 recombination activating 2 ISO CTD Direct Evidence: therapeutic CTD PMID:20974942 NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO RGD PMID:21665435, PMID:19950279 RGD:5147558, RGD:5147586 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G S100a8 S100 calcium binding protein A8 IEP RGD PMID:8343166 RGD:633930 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 IEP RGD PMID:8343166 RGD:633930 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Serpinc1 serpin family C member 1 IEP protein:decreased expression:plasma RGD PMID:22781611 RGD:11035273 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Sfrp4 secreted frizzled-related protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25194984 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
JBrowse link
G Shh sonic hedgehog signaling molecule treatment IEP RGD PMID:25821409 RGD:12879456 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Slc11a1 solute carrier family 11 member 1 severity ISO RGD PMID:17122779 RGD:5684943 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor treatment IEP protein:decreased expression:articular cartilage of joint RGD PMID:10449524, PMID:9744360 RGD:634208, RGD:9999431 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Smo smoothened, frizzled class receptor treatment IEP RGD PMID:25821409 RGD:12879456 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Socs3 suppressor of cytokine signaling 3 IEP mRNA:increased expression:mononuclear cell RGD PMID:16507131 RGD:1625684 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Spn sialophorin IMP associated with Staphylococcal Infections RGD PMID:7927732 RGD:2303983 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Stat1 signal transducer and activator of transcription 1 IDA
ISO
protein:increased tyrosine phosphorylation:macrophage, synovial cell
CTD Direct Evidence: marker/mechanism
CTD PMID:15188379, PMID:14674010 RGD:1582346 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:15188379, PMID:21937456, PMID:23711144 RGD:10403081 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9259450 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP RGD PMID:29763498 RGD:15036801 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEP protein:increased expression:synovium RGD PMID:9010265 RGD:1601623 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Thbd thrombomodulin ISO RGD PMID:16879225 RGD:5685015 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 IMP RGD PMID:12483743 RGD:2290463 NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467
JBrowse link
G Tjp1 tight junction protein 1 IEP RGD PMID:18848892 RGD:2325138 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr2 toll-like receptor 2 IEP
ISO
RGD PMID:21725847, PMID:20131263 RGD:7241099, RGD:8552884 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr3 toll-like receptor 3 IEP
IMP
mRNA, protein:increased expression:spleen (rat) RGD PMID:20500834, PMID:20500834 RGD:5128706, RGD:5128706 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tnf tumor necrosis factor treatment IDA
IEP
ISO
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:
CTD PMID:7589090, PMID:9598899, PMID:19203382, PMID:19330884, PMID:19765281, PMID:20131233, PMID:20974942, PMID:21452922, PMID:22450443, PMID:23052485, PMID:29408684, PMID:24028507, PMID:24394943, PMID:19169271, PMID:21690068, PMID:23140046 RGD:7245941, RGD:13792834, RGD:10755447, RGD:10450611, RGD:8662976, RGD:8661761, RGD:7193038 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B IEP
ISO
mRNA:decreased expression:bone
CTD Direct Evidence: therapeutic
CTD PMID:23333834, PMID:16696922 RGD:1624171 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment IDA
IEP
ISO
RGD PMID:23052485, PMID:21690068, PMID:20370892 RGD:7245941, RGD:8661761, RGD:8661729 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B treatment ISO
IEP
IDA
human protein in rat model RGD PMID:21463515, PMID:21690068, PMID:23052485 RGD:5131255, RGD:8661761, RGD:7245941 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 treatment ISO RGD PMID:25869297 RGD:9999444 NCBI chr10:48,903,540...48,925,036
Ensembl chr10:48,903,540...48,925,030
JBrowse link
G Txndc5 thioredoxin domain containing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23326410 NCBI chr17:26,925,828...26,953,981
Ensembl chr17:26,925,828...26,953,970
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:9598899, PMID:26221077 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin IDA RGD PMID:7516431 RGD:6480480 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vip vasoactive intestinal peptide ISO
IDA
RGD PMID:21998117, PMID:19055696 RGD:5685376, RGD:5685612 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
G Xdh xanthine dehydrogenase IEP protein:increased expression:brain, mitochondrion RGD PMID:25870945 RGD:13208957 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Xylt1 xylosyltransferase 1 IEP mRNA:decreased expression:articular cartilage RGD PMID:19001053 RGD:2313142 NCBI chr 1:186,939,698...187,264,758
Ensembl chr 1:187,149,453...187,261,632
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    Animal Diseases 1627
      Animal Disease Models 1585
        Experimental Arthritis 312
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      Skin and Connective Tissue Diseases 5476
        connective tissue disease 4103
          bone disease 3534
            bone inflammation disease 941
              arthritis 914
                Experimental Arthritis 312
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.