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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Neointima
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Accession:DOID:9002514 term browser browse the term
Definition:The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
Synonyms:exact_synonym: Neointima Formation;   Neointimas
 primary_id: MESH:D058426;   RDO:0007826
For additional species annotation, visit the Alliance of Genome Resources.


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Neointima term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment ISO RGD PMID:24132651 RGD:8695998 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19258495, PMID:29609002 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment ISO RGD PMID:23535897 RGD:13782090 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20671235 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Axl Axl receptor tyrosine kinase IEP RGD PMID:9758639 RGD:631894 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Becn1 beclin 1 IMP RGD PMID:25238224 RGD:11558011 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Clu clusterin ISO RGD PMID:19696405, PMID:20032585 RGD:8699512, RGD:9068412 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cybb cytochrome b-245 beta chain treatment IMP RGD PMID:20485380 RGD:11040762 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Drd4 dopamine receptor D4 treatment IDA associated with type 2 diabetes mellitus RGD PMID:24888351 RGD:13506962 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Ece1 endothelin converting enzyme 1 IEP mRNA:increased expression:carotid artery RGD PMID:8575076 RGD:7244170 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 treatment ISO RGD PMID:18485080 RGD:9685444 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Epc1 enhancer of polycomb homolog 1 treatment ISO RGD PMID:22398275 RGD:9587795 NCBI chr17:57,303,968...57,394,975
Ensembl chr17:57,304,933...57,394,985
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP RGD PMID:17438359 RGD:2289992 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G F3 coagulation factor III, tissue factor treatment IEP RGD PMID:22140576 RGD:11341672 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf2 fibroblast growth factor 2 IEP RGD PMID:8808969 RGD:8655643 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IDA RGD PMID:15072997 RGD:10402089 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 treatment IEP
IMP
mRNA,protein:increased expression:smooth muscle cell: RGD PMID:9400373, PMID:22814749 RGD:10402128, RGD:10402146 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Foxo4 forkhead box O4 ISO protein:increased expression:smooth muscle cell: RGD PMID:17242183, PMID:16054032 RGD:10402361, RGD:10402362 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158
JBrowse link
G Gas6 growth arrest specific 6 IEP RGD PMID:9758639 RGD:631894 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Hmox1 heme oxygenase 1 treatment IMP RGD PMID:21804207 RGD:10755571 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 ISO associated with Hypertension RGD PMID:12791939 RGD:1580477 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO associated with Vascular System Injuries RGD PMID:23657573 RGD:11049552 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Klf5 Kruppel-like factor 5 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:16224062, PMID:10417400 RGD:1581746 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Lgals3 galectin 3 IEP mRNA:increased expression:thoracic aorta RGD PMID:9688561 RGD:9685205 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IMP RGD PMID:14638553 RGD:10412321 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mir125a microRNA 125a treatment IMP RGD PMID:30156956 RGD:26884369 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD PMID:17964422, PMID:23344254 RGD:13207403 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD PMID:17964422, PMID:23344254 RGD:13207403 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myb MYB proto-oncogene, transcription factor treatment IMP RGD PMID:10438864 RGD:11532744 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 IMP RGD PMID:22508052 RGD:11073699 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nrg1 neuregulin 1 IEP RGD PMID:17438359 RGD:2289992 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IDA
IMP
RGD PMID:22922962, PMID:19359598 RGD:10041068, RGD:11533945 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP RGD PMID:15044192 RGD:10413907 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP RGD PMID:8585266 RGD:10449489 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:20307651 RGD:8693429 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP associated with Carotid Artery Injuries RGD PMID:22922962 RGD:10041068 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29609002 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Selp selectin P treatment IMP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Senp1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 7:139,626,444...139,684,587
Ensembl chr 7:139,630,515...139,675,245
JBrowse link
G Serpine1 serpin family E member 1 treatment IMP
ISO
associated with Diabetes Mellitus, Type 2
human protein in rat model
RGD PMID:18091579, PMID:19574558 RGD:8547879, RGD:8547913 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Ssh1 slingshot protein phosphatase 1 IEP protein:increased expression:carotid artery RGD PMID:21868701 RGD:11535005 NCBI chr12:48,403,184...48,447,964
Ensembl chr12:48,403,797...48,446,977
JBrowse link
G Stat4 signal transducer and activator of transcription 4 treatment IDA associated with Carotid Artery Injuries RGD PMID:16118253 RGD:5509614 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO
IEP
RGD PMID:10521388, PMID:22140576 RGD:11060274, RGD:11341672 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:16186389 RGD:13463598 NCBI chr12:2,517,006...2,533,707
Ensembl chr12:2,517,006...2,533,706
JBrowse link
G Yy1 YY1 transcription factor treatment IMP RGD PMID:21030713 RGD:9588268 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    Pathological Conditions, Signs and Symptoms 8726
      Pathologic Processes 6130
        Neointima 49
Path 2
Term Annotations click to browse term
  disease 16108
    Pathological Conditions, Signs and Symptoms 8726
      Pathologic Processes 6130
        Hyperplasia 116
          Intimal Hyperplasia 60
            Neointima 49
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.