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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Serotonin Syndrome
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Accession:DOID:9002607 term browser browse the term
Definition:An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
Synonyms:exact_synonym: Serotonin Syndromes
 primary_id: MESH:D020230;   RDO:0007364
For additional species annotation, visit the Alliance of Genome Resources.


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Serotonin Syndrome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cabp1 calcium binding protein 1 IEP protein:altered expression:postsynaptic density RGD PMID:19224364 RGD:14399959 NCBI chr12:47,185,449...47,209,785
Ensembl chr12:47,179,664...47,209,784
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16058
    syndrome 6996
      Serotonin Syndrome 1
Path 2
Term Annotations click to browse term
  disease 16058
    Chemically-Induced Disorders 1194
      Drug-Related Side Effects and Adverse Reactions 589
        Serotonin Syndrome 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.