ONTOLOGY REPORT - ANNOTATIONS


Term:Premature Aging
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Accession:DOID:9002644 term browser browse the term
Definition:Changes in the organism associated with senescence, occurring at an accelerated rate.
Synonyms:primary_id: MESH:D019588
 alt_id: RDO:0007285
For additional species annotation, visit the Alliance of Genome Resources.


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Premature Aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:11554173
G Arhgap1 Rho GTPase activating protein 1 JBrowse link 3 80,555,196 80,576,881 RGD:10043350
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:10043345
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480478
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480478
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:10059406
G Bub3 BUB3 mitotic checkpoint protein JBrowse link 1 203,526,853 203,537,459 RGD:10059413
G Cdc14b cell division cycle 14B JBrowse link 17 1,709,703 1,797,732 RGD:10059338
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:10043192
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:10043189
RGD:10043192
G Coq7 coenzyme Q7, hydroxylase JBrowse link 1 188,176,060 188,190,874 RGD:10402088
G Efemp1 EGF containing fibulin extracellular matrix protein 1 JBrowse link 14 113,202,382 113,294,993 RGD:10401789
G Eif5a2 eukaryotic translation initiation factor 5A2 JBrowse link 2 115,336,646 115,354,203 RGD:10395359
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:10045610
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:11554173
G Ext1 exostosin glycosyltransferase 1 JBrowse link 7 92,605,008 92,881,392 RGD:13208511
G Fgf23 fibroblast growth factor 23 JBrowse link 4 159,622,404 159,630,082 RGD:10044240
RGD:10045876
G Foxo1 forkhead box O1 JBrowse link 2 141,451,234 141,527,016 RGD:10045361
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:10401826
RGD:10401863
G Hells helicase, lymphoid specific JBrowse link 1 257,901,856 257,953,889 RGD:10402190
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:10043099
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:10402865
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:10045876
G Kl Klotho JBrowse link 12 942,974 987,206 RGD:10403047
RGD:11554173
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:10412708
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:10412052
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:10412323
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:10412691
G Nudt1 nudix hydrolase 1 JBrowse link 12 16,391,578 16,398,771 RGD:10449033
G Polg DNA polymerase gamma, catalytic subunit JBrowse link 1 141,172,117 141,188,893 RGD:8694320
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:10045876
G Wrn Werner syndrome RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:11554173
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:10043096
branchiootic syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:7240710
RGD:8554872
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:13592920
Branchiootic Syndrome 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:7240710
RGD:8554872
branchiootorenal syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:1598917
RGD:8554872
RGD:11554173
RGD:8554897
RGD:8554880
RGD:7240710
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:8554876
RGD:8554872
RGD:11554173
RGD:11064057
RGD:8554882
RGD:8554880
RGD:8554879
G Six5 SIX homeobox 5 JBrowse link 1 80,000,106 80,005,303 RGD:7240710
RGD:8554872
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:11554173
Cerebrooculofacioskeletal Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:8554872
Cerebrooculofacioskeletal Syndrome 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:8554872
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:7240710
RGD:8554872
RGD:10401101
RGD:10401092
Cerebrooculofacioskeletal Syndrome 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:1601070
RGD:8554872
RGD:7240710
Cerebrooculofacioskeletal Syndrome 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:8554872
RGD:7240710
Cerebrooculofacioskeletal Syndrome 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:7240710
RGD:8554872
Cockayne syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:8554872
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:10401080
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit JBrowse link 18 25,037,668 25,068,380 RGD:10401087
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:10401090
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:8554872
RGD:11554173
RGD:11567232
RGD:10401100
RGD:10401095
G Ercc8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit JBrowse link 2 39,434,617 39,473,392 RGD:7246919
RGD:11064547
RGD:8554872
RGD:11554173
RGD:10401108
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:10003139
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:10003139
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 JBrowse link 2 39,322,145 39,434,535 RGD:8554872
G Xpa XPA, DNA damage recognition and repair factor JBrowse link 5 61,749,767 61,793,641 RGD:10401087
Cockayne Syndrome A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit JBrowse link 2 39,434,617 39,473,392 RGD:10401106
RGD:8554872
RGD:7240710
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 JBrowse link 2 39,322,145 39,434,535 RGD:8554872
Cockayne Syndrome B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:8554872
RGD:7240710
Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pold1 DNA polymerase delta 1, catalytic subunit JBrowse link 1 100,538,066 100,554,105 RGD:7240710
RGD:8554872
Nestor-Guillermo Progeria Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Banf1 barrier to autointegration factor 1 JBrowse link 1 220,744,195 220,746,224 RGD:7240710
RGD:8554872
G Eif1ad eukaryotic translation initiation factor 1A domain containing JBrowse link 1 220,746,387 220,751,687 RGD:8554872
Otofaciocervical Syndrome 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eya1 EYA transcriptional coactivator and phosphatase 1 JBrowse link 5 4,275,728 4,495,525 RGD:7240710
RGD:8554872
G Pax1 paired box 1 JBrowse link 3 141,577,124 141,589,849 RGD:11554173
Otofaciocervical Syndrome 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pax1 paired box 1 JBrowse link 3 141,577,124 141,589,849 RGD:7240710
RGD:8554872
Penttinen-Aula Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:7240710
RGD:8554872
progeria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ank3 ankyrin 3 JBrowse link 20 19,948,767 20,480,628 RGD:11554173
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 JBrowse link 17 26,785,017 26,795,723 RGD:10401221
G Gh1 growth hormone 1 JBrowse link 10 94,486,204 94,488,181 RGD:10003141
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:10003141
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:7240710
RGD:8554872
RGD:11554173
RGD:12791022
RGD:10003159
RGD:10003158
RGD:10003156
RGD:10003154
RGD:737720
G Pycr1 pyrroline-5-carboxylate reductase 1 JBrowse link 10 109,817,300 109,822,218 RGD:11554173
G Sirt6 sirtuin 6 JBrowse link 7 10,937,622 10,943,048 RGD:13592920
G Sprtn SprT-like N-terminal domain JBrowse link 19 57,649,901 57,657,158 RGD:11554173
G Sun1 Sad1 and UNC84 domain containing 1 JBrowse link 12 17,488,482 17,533,334 RGD:10044242
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:11554173
Progeria Syndrome, Childhood-Onset term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:8554872
Progeroid Syndrome, Congenital, Petty Type term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc25a24 solute carrier family 25 member 24 JBrowse link 2 211,930,371 211,967,511 RGD:8554872
RGD:7240710
Ruijs-Aalfs Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sprtn SprT-like N-terminal domain JBrowse link 19 57,649,901 57,657,158 RGD:8554872
RGD:7240710
Werner syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:10402544
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:12791031
G Purg purine-rich element binding protein G JBrowse link 16 62,427,933 62,483,295 RGD:8554872
G Wrn Werner syndrome RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:1580825
RGD:8554872
RGD:11554173
RGD:7240710
Wolfram syndrome 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cisd2 CDGSH iron sulfur domain 2 JBrowse link 2 240,586,754 240,611,560 RGD:7240710
RGD:8554872
RGD:11554173
RGD:10045603
RGD:10045601
G Slc9b1 solute carrier family 9 member B1 JBrowse link 2 240,527,120 240,581,616 RGD:8554872
XFE progeroid syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:13592920
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14920
    Diseases of the Aged 1162
      Premature Aging 64
        Cockayne syndrome + 11
        Premature Aging, Okamoto Type 0
        Werner syndrome + 4
        Wolfram syndrome 2 2
        branchiootorenal syndrome + 5
        progeria + 15
Path 2
Term Annotations click to browse term
  disease 14920
    Pathological Conditions, Signs and Symptoms 7743
      Signs and Symptoms 4469
        Premature Aging 64
          Cockayne syndrome + 11
          Premature Aging, Okamoto Type 0
          Werner syndrome + 4
          Wolfram syndrome 2 2
          branchiootorenal syndrome + 5
          progeria + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.