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Term:Experimental Autoimmune Encephalomyelitis
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Accession:DOID:9002763 term browser browse the term
Definition:An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Synonyms:exact_synonym: Allergic Encephalomyelitis;   EAE;   Experimental Allergic Encephalomyelitides;   Experimental Allergic Encephalomyelitis
 primary_id: MESH:D004681
 alt_id: RDO:0005474
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Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:10046021
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:1559178
G Adam8 ADAM metallopeptidase domain 8 JBrowse link 1 212,317,510 212,332,895 RGD:2325244
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:2313022
G Akap12 A-kinase anchoring protein 12 JBrowse link 1 40,816,130 40,906,582 RGD:14348972
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:5509618
G Amigo2 adhesion molecule with Ig like domain 2 JBrowse link 7 138,704,124 138,707,221 RGD:14392778
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:2306942
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:13703134
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:5148015
RGD:8696030
RGD:5490117
RGD:5490116
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:6482690
G B4galt6 beta-1,4-galactosyltransferase 6 JBrowse link 18 15,462,913 15,525,584 RGD:14390079
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:10059360
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:7175513
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:625607
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:1580151
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:5684360
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:2311436
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:2311436
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:2311436
G Cav3 caveolin 3 JBrowse link 4 144,382,945 144,398,919 RGD:1582168
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:11554173
G Ccl1 C-C motif chemokine ligand 1 JBrowse link 10 69,534,976 69,537,836 RGD:4145472
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:4145472
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:2307114
RGD:4145472
RGD:8548888
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:2307114
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:4890027
RGD:2307114
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:5688165
RGD:5688167
G Ccr2 C-C motif chemokine receptor 2 RGD:632391
G Ccr3 C-C motif chemokine receptor 3 JBrowse link 8 133,026,539 133,040,999 RGD:6893394
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:4890436
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:2307203
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:10058963
RGD:10058968
G Cd80 Cd80 molecule JBrowse link 11 64,815,201 64,855,293 RGD:6902906
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:4892227
RGD:4892207
G Ciita class II, major histocompatibility complex, transactivator JBrowse link 10 5,212,621 5,260,641 RGD:1358146
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase JBrowse link 10 88,490,798 88,497,357 RGD:6483335
RGD:6483353
RGD:6483351
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:13450949
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:7243111
G Cspg4 chondroitin sulfate proteoglycan 4 JBrowse link 8 61,532,465 61,567,510 RGD:5686852
RGD:5686863
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:6902906
G Ctsc cathepsin C JBrowse link 1 151,918,514 151,949,979 RGD:1599653
G Ctss cathepsin S JBrowse link 2 197,655,780 197,679,768 RGD:5686915
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:4891973
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:4891973
RGD:9491767
G Cxcr2 C-X-C motif chemokine receptor 2 JBrowse link 9 81,427,275 81,435,065 RGD:7257694
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:5135506
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:7243155
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:6482235
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:7775013
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 JBrowse link 1 259,692,020 259,818,922 RGD:9685491
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:11554173
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:5508732
RGD:5508735
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:12903984
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:5508383
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:8655647
RGD:9831448
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:10402153
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:11554173
G Ghrh growth hormone releasing hormone JBrowse link 3 153,449,124 153,468,794 RGD:5687168
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:12905041
G Gjc2 gap junction protein, gamma 2 JBrowse link 10 45,526,740 45,535,520 RGD:13208593
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:12801440
G Glud1 glutamate dehydrogenase 1 JBrowse link 16 10,661,486 10,695,557 RGD:6484657
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:9686086
RGD:9686113
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:5508469
RGD:5508476
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:7987912
RGD:10755692
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6483353
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:7364993
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:2316323
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:724447
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:4831840
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:5684366
RGD:5684367
G Il16 interleukin 16 JBrowse link 1 145,781,923 145,881,538 RGD:5024940
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:4831840
RGD:9212317
RGD:4888522
RGD:4889113
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:4889543
RGD:4889542
G Il18r1 interleukin 18 receptor 1 JBrowse link 9 47,184,404 47,217,403 RGD:2311529
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:8551836
G Il21 interleukin 21 JBrowse link 2 123,965,021 123,972,356 RGD:5147399
G Il21r interleukin 21 receptor JBrowse link 1 196,996,405 197,024,185 RGD:6892939
RGD:6892940
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:2311529
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:2311529
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:7829778
RGD:8142395
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:2307412
RGD:12791289
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:9698418
RGD:9698436
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:6482235
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6483041
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:11533939
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:5684404
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:12910744
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:13800552
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:1625038
RGD:4143220
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:1358431
G Mbp myelin basic protein JBrowse link 18 79,326,738 79,437,310 RGD:7349334
RGD:11554173
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:9831448
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:2325703
G Mmp7 matrix metallopeptidase 7 JBrowse link 8 5,893,253 5,900,965 RGD:8547909
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:8547909
RGD:13204801
RGD:13204762
RGD:8547936
G Mog myelin oligodendrocyte glycoprotein JBrowse link 20 2,003,871 2,014,284 RGD:9685372
RGD:11554173
RGD:9685375
RGD:9685373
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6484112
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6484112
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:6484112
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:2299007
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11554173
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:5508386
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508312
RGD:5508386
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5509069
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 JBrowse link 1 100,554,577 100,559,896 RGD:6480877
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:4892331
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:5684777
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:11080975
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:11080975
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:11080975
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:6482686
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:11554173
G Prf1 perforin 1 JBrowse link 20 30,915,294 30,920,804 RGD:6482806
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6484540
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:5688149
RGD:5688250
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5688149
RGD:5688250
G Ptn pleiotrophin JBrowse link 4 64,239,156 64,330,996 RGD:9831448
G Qk quaking JBrowse link 1 50,983,647 51,050,692 RGD:10045997
G Rangrf RAN guanine nucleotide release factor JBrowse link 10 55,559,049 55,560,420 RGD:6771380
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:2298887
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:5147622
RGD:5147639
RGD:5147666
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:5147639
RGD:5147666
RGD:5147647
G RT1-Da RT1 class II, locus Da JBrowse link 20 4,127,644 4,132,616 RGD:5490166
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:5147647
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:13208549
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:12801423
RGD:12801440
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:11554173
G Slpi secretory leukocyte peptidase inhibitor JBrowse link 3 160,799,979 160,802,228 RGD:9999395
G Sncb synuclein, beta JBrowse link 17 10,384,472 10,392,776 RGD:730073
G Srsf9 serine and arginine rich splicing factor 9 JBrowse link 12 47,039,714 47,046,022 RGD:11040805
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6483041
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6483041
RGD:6892946
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:7207888
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2302088
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:2302088
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:1559178
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:2312575
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:2312575
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:12904661
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:1580348
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:8158064
RGD:13210791
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:634258
RGD:7421596
G Vip vasoactive intestinal peptide JBrowse link 1 42,169,307 42,177,582 RGD:5685386
Acute Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mag myelin-associated glycoprotein JBrowse link 1 89,345,325 89,360,905 RGD:9685300
Chronic Relapsing Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8655962
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:13208507

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14920
    Animal Diseases 1571
      Animal Disease Models 1537
        Experimental Nervous System Autoimmune Disease 246
          Experimental Autoimmune Encephalomyelitis 212
            Acute Experimental Autoimmune Encephalomyelitis 1
            Chronic Relapsing Experimental Autoimmune Encephalomyelitis 2
Path 2
Term Annotations click to browse term
  disease 14920
    disease of anatomical entity 14086
      Immune & Inflammatory Diseases 3003
        immune system disease 2425
          Autoimmune Diseases 1455
            autoimmune hypersensitivity disease 1169
              autoimmune disease of the nervous system 402
                autoimmune disease of central nervous system 329
                  Demyelinating Autoimmune Diseases, CNS 329
                    Experimental Autoimmune Encephalomyelitis 212
                      Acute Experimental Autoimmune Encephalomyelitis 1
                      Chronic Relapsing Experimental Autoimmune Encephalomyelitis 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.