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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Neonatal Alloimmune Thrombocytopenia
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Accession:DOID:9003340 term browser browse the term
Definition:A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.
Synonyms:exact_synonym: FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA;   NAIT;   Neonatal Alloimmune Thrombocytopenias;   Neonatal Thrombocytopenia;   Neonatal Thrombocytopenias
 related_synonym: BAK PLATELET-SPECIFIC ANTIGEN;   Ca/Tu Alloantigen Polymorphism;   Mo Alloantigen Polymorphism;   PEN(a)/PEN(b) Alloantigen Polymorphism
 primary_id: MESH:D054098
 alt_id: RDO:0007658
For additional species annotation, visit the Alliance of Genome Resources.


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Neonatal Alloimmune Thrombocytopenia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itga2b integrin subunit alpha 2b ISO ClinVar Annotator: match by term: BAK PLATELET-SPECIFIC ANTIGEN ClinVar PMID:1926040, PMID:25741868 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itgb3 integrin subunit beta 3 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: PEN(a)/PEN(b) ALLOANTIGEN POLYMORPHISM
ClinVar Annotator: match by term: Fetal and neonatal alloimmune thrombocytopenia
ClinVar Annotator: match by term: Ca/Tu ALLOANTIGEN POLYMORPHISM
CTD
ClinVar
PMID:1430225, PMID:2257303, PMID:7694683, PMID:8457479, PMID:9787162, PMID:14516468, PMID:21658138, PMID:25827233, PMID:28370162, PMID:28492532 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    Developmental Diseases 9509
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 8365
        Infant, Newborn, Diseases 546
          Neonatal Alloimmune Thrombocytopenia 2
Path 2
Term Annotations click to browse term
  disease 16108
    disease of anatomical entity 15356
      Hemic and Lymphatic Diseases 2047
        hematopoietic system disease 1643
          blood coagulation disease 623
            hemorrhagic disease 610
              blood platelet disease 291
                thrombocytopenia 217
                  thrombocytopenia due to platelet alloimmunization 3
                    Neonatal Alloimmune Thrombocytopenia 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.