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Term:Paraneoplastic Cerebellar Degeneration
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Accession:DOID:9003545 term browser browse the term
Definition:Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
Synonyms:exact_synonym: Anti Yo Associated Paraneoplastic Cerebellar Degeneration;   Paraneoplastic Cerebellar Syndrome;   Paraneoplastic Cerebellar Syndromes
 primary_id: MESH:D020362;   RDO:0007401
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Path 1
Term Annotations click to browse term
  disease 15619
    disease of cellular proliferation 5796
      Paraneoplastic Syndromes 21
        Paraneoplastic Syndromes, Nervous System 16
          Paraneoplastic Cerebellar Degeneration 0
Path 2
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        central nervous system disease 8092
          brain disease 7561
            cerebellar disease 310
              Paraneoplastic Cerebellar Degeneration 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.