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ONTOLOGY REPORT - ANNOTATIONS


Term:Hepatic Insufficiency
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Accession:DOID:9004250 term browser browse the term
Definition:Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.
Synonyms:exact_synonym: Liver Insufficiency
 primary_id: MESH:D048550;   RDO:0007026
For additional species annotation, visit the Alliance of Genome Resources.


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Hepatic Insufficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALB albumin JBrowse link 4 56,605,322 56,622,418 RGD:9068941
G CYGB cytoglobin JBrowse link 17 76,167,003 76,178,247 RGD:9068941
G FGF19 fibroblast growth factor 19 JBrowse link 11 68,085,306 68,090,028 RGD:9068941
G KEAP1 kelch like ECH associated protein 1 JBrowse link 19 10,701,298 10,717,664 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 6 36,788,233 36,871,114 RGD:9068941
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2B 182,214,116 182,248,282 RGD:9068941
G NOS2 nitric oxide synthase 2 JBrowse link 17 29,477,285 29,519,412 RGD:9068941
G NOS3 nitric oxide synthase 3 JBrowse link 7 154,730,009 154,755,233 RGD:9068941
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 64,347,859 64,357,461 RGD:9068941
G TGFB1 transforming growth factor beta 1 JBrowse link 19 46,831,659 46,852,973 RGD:9068941
Acute Liver Failure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCC2 ATP binding cassette subfamily C member 2 JBrowse link 10 99,889,021 99,947,452 RGD:9068941
G ALB albumin JBrowse link 4 56,605,322 56,622,418 RGD:9068941
G ATM ATM serine/threonine kinase JBrowse link 11 106,584,228 106,728,457 RGD:9068941
G ATP7B ATPase copper transporting beta JBrowse link 13 51,808,491 51,888,488 RGD:9068941
G BRIP1 BRCA1 interacting protein C-terminal helicase 1 JBrowse link 17 60,901,073 61,083,462 RGD:9068941
G CASP3 caspase 3 JBrowse link 4 189,018,422 189,040,217 RGD:9068941
G CASP9 caspase 9 JBrowse link 1 15,624,666 15,656,266 RGD:9068941
G CAST calpastatin JBrowse link 5 97,526,828 97,639,645 RGD:9068941
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 22,821,336 22,823,271 RGD:9068941
G CD14 CD14 molecule JBrowse link 5 142,113,082 142,115,023 RGD:9068941
G CD74 CD74 molecule JBrowse link 5 151,830,311 151,841,334 RGD:9068941
G COL1A2 collagen type I alpha 2 chain JBrowse link 7 99,935,185 99,971,810 RGD:9068941
G CSF3 colony stimulating factor 3 JBrowse link 17 17,491,272 17,493,729 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 10 89,199,070 89,244,884 RGD:9068941
G FASLG Fas ligand JBrowse link 1 151,868,430 151,876,281 RGD:9068941
G FGA fibrinogen alpha chain JBrowse link 4 158,767,782 158,775,414 RGD:9068941
G FST follistatin JBrowse link 5 62,163,655 62,168,218 RGD:9068941
G GC GC vitamin D binding protein JBrowse link 4 58,749,384 58,792,073 RGD:9068941
G GFER growth factor, augmenter of liver regeneration JBrowse link 16 2,073,064 2,076,592 RGD:9068941
G GPNMB glycoprotein nmb JBrowse link 7 23,540,451 23,568,624 RGD:9068941
G HGF hepatocyte growth factor JBrowse link 7 87,325,741 87,396,850 RGD:9068941
G HSPA8 heat shock protein family A (Hsp70) member 8 JBrowse link 11 121,809,800 121,814,628 RGD:9068941
G IL1RN interleukin 1 receptor antagonist JBrowse link 2A 114,061,182 114,077,048 RGD:9068941
G IL6 interleukin 6 JBrowse link 7 23,027,560 23,032,419 RGD:9068941
G INHBA inhibin subunit beta A JBrowse link 7 42,580,730 42,598,712 RGD:9068941
G INS insulin JBrowse link 11 2,230,309 2,231,666 RGD:9068941
G KCNJ10 potassium voltage-gated channel subfamily J member 10 JBrowse link 1 139,312,371 139,345,145 RGD:9068941
G KIT KIT proto-oncogene, receptor tyrosine kinase JBrowse link 4 75,761,946 75,844,473 RGD:9068941
G KRT18 keratin 18 JBrowse link 12 36,587,149 36,591,196 RGD:9068941
G KRT8 keratin 8 JBrowse link 12 36,634,582 36,642,564 RGD:9068941
G LOC100988585 protein SCO1 homolog, mitochondrial JBrowse link 17 45,703,642 45,720,520 RGD:9068941
G LRP1 LDL receptor related protein 1 JBrowse link 12 31,966,149 32,051,979 RGD:9068941
G LTC4S leukotriene C4 synthase JBrowse link 5 182,256,113 182,261,003 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 RGD:9068941
G MET MET proto-oncogene, receptor tyrosine kinase JBrowse link 7 121,365,429 121,468,159 RGD:9068941
G MILR1 mast cell immunoglobulin like receptor 1 JBrowse link 17 63,638,549 63,663,492 RGD:9068941
G NOS2 nitric oxide synthase 2 JBrowse link 17 29,477,285 29,519,412 RGD:9068941
G POLG2 DNA polymerase gamma 2, accessory subunit JBrowse link 17 63,667,246 63,686,503 RGD:9068941
G POMC proopiomelanocortin JBrowse link 2A 25,258,768 25,266,806 RGD:9068941
G PTAFR platelet activating factor receptor JBrowse link 1 28,447,178 28,474,623 RGD:9068941
G SERPINC1 serpin family C member 1 JBrowse link 1 153,126,031 153,139,369 RGD:9068941
G THBD thrombomodulin JBrowse link 20 23,343,758 23,347,966 RGD:9068941
G TLR4 toll like receptor 4 JBrowse link 9 117,180,250 117,193,510 RGD:9068941
G TNF tumor necrosis factor JBrowse link 6 32,126,618 32,129,389 RGD:9068941
G UCP2 uncoupling protein 2 JBrowse link 11 72,354,529 72,363,185 RGD:9068941
Acute-On-Chronic Liver Failure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GFER growth factor, augmenter of liver regeneration JBrowse link 16 2,073,064 2,076,592 RGD:9068941
G HMGB1 high mobility group box 1 JBrowse link 13 30,173,875 30,179,527 RGD:9068941
G TLR4 toll like receptor 4 JBrowse link 9 117,180,250 117,193,510 RGD:9068941
Combined Oxidative Phosphorylation Deficiency 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GFM1 G elongation factor mitochondrial 1 JBrowse link 3 163,721,473 163,769,454 RGD:7240710
RGD:9068941
G MRPS22 mitochondrial ribosomal protein S22 JBrowse link 3 143,638,771 143,993,852 RGD:9068941
G NARS2 asparaginyl-tRNA synthetase 2, mitochondrial JBrowse link 11 77,117,668 77,255,037 RGD:9068941
G VARS2 valyl-tRNA synthetase 2, mitochondrial JBrowse link 6 31,527,503 31,539,814 RGD:9068941
End Stage Liver Disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB4 ATP binding cassette subfamily B member 4 JBrowse link 7 93,046,085 93,119,439 RGD:9068941
G MAOA monoamine oxidase A JBrowse link X 43,931,198 44,022,199 RGD:9068941
G NOS1 nitric oxide synthase 1 JBrowse link 12 118,163,655 118,314,005 RGD:9068941
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 12 6,374,256 6,387,613 RGD:9068941
G TSPO translocator protein JBrowse link 22 42,233,186 42,244,930 RGD:9068941
hepatic encephalopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EPOR erythropoietin receptor JBrowse link 19 11,635,248 11,642,383 RGD:9068941
G G6PD glucose-6-phosphate dehydrogenase JBrowse link X 153,843,092 153,860,675 RGD:9068941
G GABRA1 gamma-aminobutyric acid type A receptor alpha1 subunit JBrowse link 5 163,928,392 163,981,127 RGD:9068941
G GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit JBrowse link 4 85,458,810 85,894,427 RGD:9068941
G GABRG2 gamma-aminobutyric acid type A receptor gamma2 subunit JBrowse link 5 164,135,166 164,222,179 RGD:9068941
G GC GC vitamin D binding protein JBrowse link 4 58,749,384 58,792,073 RGD:9068941
G GLUD1 glutamate dehydrogenase 1 RGD:9068941
G GLUL glutamate-ammonia ligase JBrowse link 1 161,534,106 161,543,411 RGD:9068941
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 5 154,877,807 155,204,660 RGD:9068941
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 14 60,552,374 60,604,885 RGD:9068941
G HMOX1 heme oxygenase 1 JBrowse link 22 34,230,825 34,244,063 RGD:9068941
G LTA lymphotoxin alpha JBrowse link 6 32,123,353 32,125,375 RGD:9068941
G MAOA monoamine oxidase A JBrowse link X 43,931,198 44,022,199 RGD:9068941
G MAOB monoamine oxidase B JBrowse link X 44,042,000 44,157,846 RGD:9068941
G NOS1 nitric oxide synthase 1 JBrowse link 12 118,163,655 118,314,005 RGD:9068941
G NOS2 nitric oxide synthase 2 JBrowse link 17 29,477,285 29,519,412 RGD:9068941
G OPRM1 opioid receptor mu 1 JBrowse link 6 156,517,666 156,627,758 RGD:9068941
G PRKDC protein kinase, DNA-activated, catalytic subunit JBrowse link 8 41,593,022 41,778,299 RGD:9068941
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 121,837,095 121,859,283 RGD:9068941
G TNF tumor necrosis factor JBrowse link 6 32,126,618 32,129,389 RGD:9068941
G TSPO translocator protein JBrowse link 22 42,233,186 42,244,930 RGD:9068941
Infantile Liver Failure Syndrome 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LARS leucyl-tRNA synthetase JBrowse link 5 147,577,848 147,646,298 RGD:7240710
RGD:9068941
Infantile Liver Failure Syndrome 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MARS methionyl-tRNA synthetase JBrowse link 12 31,668,634 31,693,988 RGD:9068941
G NBAS neuroblastoma amplified sequence JBrowse link 2A 15,293,512 15,685,820 RGD:7240710
RGD:9068941
Infantile Liver Failure, Transient term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase JBrowse link 22 45,399,506 45,421,439 RGD:7240710
RGD:9068941
INTERSTITIAL LUNG AND LIVER DISEASE term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARHGAP9 Rho GTPase activating protein 9 JBrowse link 12 31,701,480 31,710,064 RGD:9068941
G FARSB phenylalanyl-tRNA synthetase subunit beta JBrowse link 2B 228,394,238 228,478,345 RGD:9068941
G MARS methionyl-tRNA synthetase JBrowse link 12 31,668,634 31,693,988 RGD:7240710
RGD:9068941
Liver Failure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACADM acyl-CoA dehydrogenase medium chain JBrowse link 1 76,911,763 76,950,840 RGD:9068941
G ARG1 arginase 1 JBrowse link 6 133,479,966 133,491,162 RGD:9068941
G ASL argininosuccinate lyase JBrowse link 7 73,142,764 73,157,472 RGD:9068941
G ASS1 argininosuccinate synthase 1 JBrowse link 9 130,219,993 130,276,036 RGD:9068941
G CPS1 carbamoyl-phosphate synthase 1 JBrowse link 2B 216,136,857 216,337,728 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link 11 47,227,891 47,249,157 RGD:9068941
G FAH fumarylacetoacetate hydrolase JBrowse link 15 78,081,523 78,115,169 RGD:9068941
G IL18 interleukin 18 JBrowse link 11 110,867,586 110,888,371 RGD:9068941
G LOC100972194 40S ribosomal protein S6 JBrowse link 9 19,674,380 19,678,397 RGD:9068941
G OTC ornithine carbamoyltransferase JBrowse link X 38,505,232 38,575,819 RGD:9068941
G RPS9 ribosomal protein S9 JBrowse link 19 59,974,377 59,981,236 RGD:9068941
G VEGFA vascular endothelial growth factor A JBrowse link 6 44,651,855 44,666,353 RGD:9068941
Massive Hepatic Necrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PRKDC protein kinase, DNA-activated, catalytic subunit JBrowse link 8 41,593,022 41,778,299 RGD:9068941
mitochondrial DNA depletion syndrome 15 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TFAM transcription factor A, mitochondrial JBrowse link 10 57,137,911 57,152,102 RGD:9068941
RGD:7240710
mitochondrial DNA depletion syndrome 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DGUOK deoxyguanosine kinase JBrowse link 2A 75,510,768 75,542,563 RGD:7240710
RGD:9068941
G MPV17 mitochondrial inner membrane protein MPV17 JBrowse link 2A 27,399,258 27,412,747 RGD:9068941
Small-For-Size Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAD BCL2 associated agonist of cell death JBrowse link 11 62,971,808 62,986,304 RGD:9068941
G IL1B interleukin 1 beta JBrowse link 2A 113,846,299 113,853,424 RGD:9068941
G VEGFA vascular endothelial growth factor A JBrowse link 6 44,651,855 44,666,353 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11205
    disease of anatomical entity 10709
      endocrine system disease 3826
        liver disease 2026
          Hepatic Insufficiency 101
            INTERSTITIAL LUNG AND LIVER DISEASE 3
            Liver Failure + 89
            Small-For-Size Syndrome 3
Path 2
Term Annotations click to browse term
  disease 11205
    disease of anatomical entity 10709
      gastrointestinal system disease 3594
        hepatobiliary disease 2107
          liver disease 2026
            Hepatic Insufficiency 101
              INTERSTITIAL LUNG AND LIVER DISEASE 3
              Liver Failure + 89
              Small-For-Size Syndrome 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.