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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Tubulointerstitial Fibrosis
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Accession:DOID:9004303 term browser browse the term
Definition:A pathological condition where fibrous connective tissue invades the tubules and interstitium of the kidney.
Synonyms:narrow_synonym: renal interstitial fibrosis
 primary_id: RDO:9000788
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
Tubulointerstitial Fibrosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epo erythropoietin treatment ISO RGD PMID:22678524 RGD:10401065 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit IEP RGD PMID:21152904 RGD:5134352 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IMP
mRNA:increased expression:kidney RGD PMID:23249995, PMID:15007308 RGD:13446413, RGD:1304308 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbi transforming growth factor, beta induced IEP mRNA, protein:increased expression:kidney RGD PMID:15007308 RGD:1304308 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    Pathological Conditions, Signs and Symptoms 8726
      Pathologic Processes 6130
        Fibrosis 1415
          renal fibrosis 176
            Tubulointerstitial Fibrosis 8
Path 2
Term Annotations click to browse term
  disease 16108
    disease of anatomical entity 15356
      Urogenital Diseases 4145
        urinary system disease 2069
          kidney disease 1857
            renal fibrosis 176
              Tubulointerstitial Fibrosis 8
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.