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ONTOLOGY REPORT - ANNOTATIONS


Term:TDP-43 Proteinopathies
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Accession:DOID:9004479 term browser browse the term
Definition:Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
Synonyms:exact_synonym: TDP-43 Proteinopathy
 primary_id: MESH:D057177;   RDO:0004818
For additional species annotation, visit the Alliance of Genome Resources.


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amyotrophic lateral sclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adarb1 adenosine deaminase, RNA-specific, B1 JBrowse link 20 11,972,352 12,101,022 RGD:10755336
RGD:13592920
RGD:13432092
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:5509081
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:1599080
G Ang angiogenin JBrowse link 15 28,022,926 28,028,636 RGD:6892707
RGD:6892718
RGD:6892716
RGD:6892713
G Aox1 aldehyde oxidase 1 JBrowse link 9 64,929,682 65,007,872 RGD:734575
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:12880359
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:5490153
RGD:8662893
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:11561951
G Atox1 antioxidant 1 copper chaperone JBrowse link 10 40,790,850 40,805,886 RGD:13524567
G Atxn2 ataxin 2 JBrowse link 12 40,264,601 40,335,637 RGD:11554173
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:13506907
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:13506803
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:13506797
RGD:13506907
RGD:13506805
RGD:13506803
RGD:13506800
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:13506907
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:13506902
RGD:13506907
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561951
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:13506949
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:13506949
G Bptf bromodomain PHD finger transcription factor JBrowse link 10 95,248,573 95,350,162 RGD:9586057
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:5130169
G C5ar1 complement C5a receptor 1 JBrowse link 1 78,186,777 78,195,132 RGD:5130169
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:8554872
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:5684010
G Camk1g calcium/calmodulin-dependent protein kinase IG JBrowse link 13 112,075,689 112,099,472 RGD:11554173
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:2311466
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:2311466
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:2311466
G Ccr2 C-C motif chemokine receptor 2 RGD:8657363
G Ccs copper chaperone for superoxide dismutase JBrowse link 1 220,075,251 220,096,319 RGD:13524551
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:5490547
RGD:11554173
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:734741
G Cfap410 cilia and flagella associated protein 410 JBrowse link 20 11,417,428 11,424,301 RGD:11554173
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688711
RGD:11554173
G Cntf ciliary neurotrophic factor JBrowse link 1 229,599,009 229,601,032 RGD:734796
G Ctsh cathepsin H JBrowse link 8 97,439,155 97,458,293 RGD:5686391
G Dbr1 debranching RNA lariats 1 JBrowse link 8 107,826,690 107,838,186 RGD:11554173
G Dctn1 dynactin subunit 1 JBrowse link 4 114,876,770 114,896,567 RGD:8554872
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:9589066
G Dpp6 dipeptidyl peptidase like 6 JBrowse link 4 4,021,021 4,943,675 RGD:5687188
RGD:11554173
RGD:5687181
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:2301741
G Epg5 ectopic P-granules autophagy protein 5 homolog JBrowse link 18 74,299,965 74,397,115 RGD:13592920
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10395391
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:5509900
RGD:11554173
RGD:9685710
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6218978
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:11554173
G Gjc2 gap junction protein, gamma 2 JBrowse link 10 45,526,740 45,535,520 RGD:13208591
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:13506239
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509593
RGD:5509619
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:2301741
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:2301741
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:11554173
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:11554173
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:9681450
G Hes1 hes family bHLH transcription factor 1 JBrowse link 11 74,312,837 74,315,249 RGD:13524575
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:13524575
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:10402056
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:10058964
G Hrk harakiri, BCL2 interacting protein JBrowse link 12 44,008,879 44,029,211 RGD:13506949
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:12904708
G Igf2r insulin-like growth factor 2 receptor JBrowse link 1 48,176,095 48,264,482 RGD:2311519
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:6482791
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:13524575
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 JBrowse link 13 90,722,945 90,753,338 RGD:8662893
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:1580568
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6893397
G Kif1b kinesin family member 1B JBrowse link 5 165,994,803 166,133,497 RGD:12738468
RGD:12738469
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:13592920
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:5508417
G Maml1 mastermind-like transcriptional coactivator 1 JBrowse link 10 35,765,196 35,801,375 RGD:13524575
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:11561951
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:10412312
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:10412312
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:7207054
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:7207054
RGD:13204793
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:7207054
RGD:13204793
G Mobp myelin-associated oligodendrocyte basic protein JBrowse link 8 128,824,420 128,854,492 RGD:11554173
G Mstn myostatin JBrowse link 9 53,310,977 53,315,804 RGD:2303556
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6484130
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6482832
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:6480495
RGD:6480627
RGD:6480625
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:11565111
RGD:11565173
G Mtnr1a melatonin receptor 1A JBrowse link 16 50,339,358 50,358,809 RGD:13524569
G Mtrex Mtr4 exosome RNA helicase JBrowse link 2 44,726,716 44,787,013 RGD:11041891
G Nefh neurofilament heavy JBrowse link 14 85,181,572 85,191,557 RGD:1302518
RGD:13525000
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:13525000
RGD:13525006
G Nefm neurofilament medium JBrowse link 15 44,855,307 44,860,604 RGD:9698444
G Nek1 NIMA-related kinase 1 JBrowse link 16 32,321,010 32,439,421 RGD:11554173
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6893397
RGD:10412690
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5509065
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:13524575
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:6480502
RGD:8554872
RGD:11554173
RGD:6480506
RGD:6480504
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6483573
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:11554173
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11554173
G Pon2 paraoxonase 2 JBrowse link 4 30,344,705 30,380,119 RGD:5509925
G Pon3 paraoxonase 3 JBrowse link 4 30,311,981 30,338,679 RGD:5509925
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6484265
RGD:7242019
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:9999418
G Prph peripherin JBrowse link 7 140,742,406 140,746,197 RGD:8554872
G Psmc4 proteasome 26S subunit, ATPase 4 JBrowse link 1 84,978,220 84,986,536 RGD:13592920
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5688235
RGD:11554173
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 JBrowse link 4 49,941,046 50,140,764 RGD:9590123
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:2314289
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:11554173
G Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:6482832
G Scfd1 sec1 family domain containing 1 JBrowse link 6 72,124,408 72,202,703 RGD:11554173
G Serpinf1 serpin family F member 1 JBrowse link 10 62,241,750 62,254,145 RGD:8554892
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:11554173
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:2290573
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:5688710
G Slc1a2 solute carrier family 1 member 2 JBrowse link 3 92,518,679 92,665,731 RGD:1302517
RGD:11554173
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:13524567
G Slc6a1 solute carrier family 6 member 1 JBrowse link 4 146,258,842 146,292,176 RGD:11554173
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:2312367
RGD:11554173
RGD:13524551
RGD:8655880
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:11554173
RGD:11561951
G Steap2 STEAP2 metalloreductase JBrowse link 4 25,506,604 25,527,088 RGD:13524567
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687134
RGD:11554173
RGD:5687192
RGD:5687173
RGD:5687158
RGD:5687157
RGD:5687137
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6767572
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:12904653
G Tnfrsf21 TNF receptor superfamily member 21 JBrowse link 9 20,546,159 20,621,051 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:11554173
G Txnrd1 thioredoxin reductase 1 JBrowse link 7 26,946,124 26,984,400 RGD:5685032
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:5147832
RGD:8554872
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:5686382
RGD:11554173
RGD:5686384
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:5688230
RGD:8554872
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:11560790
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1580568
RGD:8554872
G Zfp106 zinc finger protein 106 JBrowse link 3 112,279,782 112,330,288 RGD:13592920
amyotrophic lateral sclerosis type 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ang angiogenin JBrowse link 15 28,022,926 28,028,636 RGD:8554872
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:11554173
G Bsg basigin (Ok blood group) JBrowse link 7 12,875,536 12,882,753 RGD:11554173
G Calb2 calbindin 2 JBrowse link 19 41,482,743 41,509,617 RGD:11554173
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:11554173
G Cd68 Cd68 molecule JBrowse link 10 56,268,726 56,270,605 RGD:11554173
G Cd7 Cd7 molecule JBrowse link 10 110,229,931 110,232,812 RGD:11554173
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:11554173
G Cntf ciliary neurotrophic factor JBrowse link 1 229,599,009 229,601,032 RGD:11554173
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:11554173
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:11554173
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:11554173
G Dbx1 developing brain homeobox 1 JBrowse link 1 104,969,218 104,973,648 RGD:11554173
G Dctn1 dynactin subunit 1 JBrowse link 4 114,876,770 114,896,567 RGD:7240710
RGD:8554872
G Fancg FA complementation group G JBrowse link 5 58,448,060 58,456,416 RGD:8554872
G Fgf6 fibroblast growth factor 6 JBrowse link 4 159,563,798 159,572,333 RGD:11554173
G Fig4 FIG4 phosphoinositide 5-phosphatase JBrowse link 20 45,922,806 46,044,754 RGD:8554872
G Fmo1 flavin containing dimethylaniline monoxygenase 1 JBrowse link 13 80,712,885 80,745,095 RGD:11554173
G Folh1 folate hydrolase 1 JBrowse link 1 150,323,768 150,395,415 RGD:737756
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:11554173
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:8554872
G Gabra1 gamma-aminobutyric acid type A receptor alpha1 subunit JBrowse link 10 27,310,718 27,371,802 RGD:11554173
G Gbx2 gastrulation brain homeobox 2 JBrowse link 9 97,063,265 97,065,855 RGD:11554173
G Gdi1 GDP dissociation inhibitor 1 JBrowse link X 156,400,734 156,407,396 RGD:11554173
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:11554173
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 JBrowse link X 127,561,843 127,829,763 RGD:11554173
G Gsx2 GS homeobox 2 JBrowse link 14 35,650,985 35,652,709 RGD:11554173
G Hsf1 heat shock transcription factor 1 JBrowse link 7 117,538,523 117,565,478 RGD:11554173
G Ina internexin neuronal intermediate filament protein, alpha JBrowse link 1 266,782,835 266,794,389 RGD:11554173
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:11554173
G Jund JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 16 20,485,028 20,486,707 RGD:11554173
G Kif3c kinesin family member 3C JBrowse link 6 27,768,943 27,815,611 RGD:11554173
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:12798528
G Kif5c kinesin family member 5C JBrowse link 3 35,014,157 35,257,417 RGD:12798528
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:11554173
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:11554173
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:8554872
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:11554173
G Nefh neurofilament heavy JBrowse link 14 85,181,572 85,191,557 RGD:7240710
RGD:8554872
G Otog otogelin JBrowse link 1 102,258,124 102,327,201 RGD:11554173
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:11554173
G Penk proenkephalin JBrowse link 5 17,056,412 17,061,762 RGD:11554173
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11554173
G Prph peripherin JBrowse link 7 140,742,406 140,746,197 RGD:7240710
G Rnase4 ribonuclease A family member 4 JBrowse link 15 28,018,040 28,035,395 RGD:8554872
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:11554173
G Selplg selectin P ligand JBrowse link 12 48,577,905 48,579,196 RGD:11554173
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N JBrowse link 6 128,073,344 128,080,878 RGD:11554173
G Setx senataxin JBrowse link 3 7,680,430 7,731,815 RGD:8554872
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:11554173
G Six2 SIX homeobox 2 JBrowse link 6 8,952,572 8,955,893 RGD:11554173
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:11554173
G Sncg synuclein, gamma JBrowse link 16 10,722,110 10,726,648 RGD:13592920
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:7240710
RGD:8554872
RGD:11554173
RGD:8655873
RGD:8655862
RGD:8655618
RGD:737689
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:13592920
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:8554872
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:11554173
G Tle3 TLE family member 3, transcriptional corepressor JBrowse link 8 66,296,509 66,342,186 RGD:11554173
G Tmsb4x thymosin beta 4, X-linked JBrowse link X 28,593,405 28,617,267 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:8554872
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:8554872
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:8554872
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:13592920
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:11554173
G Vps54 VPS54 subunit of GARP complex JBrowse link 14 106,153,407 106,207,715 RGD:13592920
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:11554173
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:11554173
amyotrophic lateral sclerosis type 10 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 11 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fig4 FIG4 phosphoinositide 5-phosphatase JBrowse link 20 45,922,806 46,044,754 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 12 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 14 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 15 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 16 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 17 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 18 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pfn1 profilin 1 JBrowse link 10 57,273,003 57,275,708 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 19 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 20 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 21 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Matr3 matrin 3 JBrowse link 18 28,351,691 28,390,764 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 22 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tuba4a tubulin, alpha 4A JBrowse link 9 82,415,599 82,419,918 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 23 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa11 annexin A11 JBrowse link 16 3,867,193 3,912,043 RGD:8554872
RGD:7240710
Amyotrophic Lateral Sclerosis Type 24 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nek1 NIMA-related kinase 1 JBrowse link 16 32,321,010 32,439,421 RGD:8554872
RGD:7240710
Amyotrophic Lateral Sclerosis Type 25 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kif5a kinesin family member 5A JBrowse link 7 70,515,832 70,552,897 RGD:8554872
RGD:7240710
amyotrophic lateral sclerosis type 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Setx senataxin JBrowse link 3 7,680,430 7,731,815 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spg11 SPG11 vesicle trafficking associated, spatacsin JBrowse link 3 113,999,600 114,064,438 RGD:7240710
RGD:8554872
amyotrophic lateral sclerosis type 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:7240710
RGD:8554872
RGD:9685712
amyotrophic lateral sclerosis type 8 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apcdd1l APC down-regulated 1 like JBrowse link 3 171,879,728 171,958,155 RGD:8554872
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:8554872
G Ctsz cathepsin Z JBrowse link 3 172,527,107 172,537,877 RGD:8554872
G Edn3 endothelin 3 JBrowse link 3 172,856,730 172,879,276 RGD:8554872
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:8554872
G Mir296 microRNA 296 JBrowse link 3 172,357,490 172,357,567 RGD:8554872
G Mir298 microRNA 298 JBrowse link 3 172,357,943 172,358,024 RGD:8554872
G Nelfcd negative elongation factor complex member C/D JBrowse link 3 172,510,840 172,527,118 RGD:8554872
G Npepl1 aminopeptidase-like 1 JBrowse link 3 172,195,115 172,207,685 RGD:8554872
G Prelid3b PRELI domain containing 3B JBrowse link 3 172,567,092 172,574,382 RGD:8554872
G Stx16 syntaxin 16 JBrowse link 3 172,154,739 172,183,699 RGD:8554872
G Tubb1 tubulin, beta 1 class VI JBrowse link 3 172,550,252 172,558,089 RGD:8554872
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:7240710
RGD:8554872
G Zfp831 zinc finger protein 831 JBrowse link 3 172,691,455 172,804,804 RGD:8554872
amyotrophic lateral sclerosis type 9 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ang angiogenin JBrowse link 15 28,022,926 28,028,636 RGD:7240710
RGD:8554872
G Rnase4 ribonuclease A family member 4 JBrowse link 15 28,018,040 28,035,395 RGD:8554872
Amyotrophic Lateral Sclerosis, Autosomal Recessive term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:8554872
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:8554872
amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 JBrowse link 3 119,258,189 119,347,084 RGD:5685005
RGD:11554173
RGD:7240710
RGD:5685008
chromosome 3-linked frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:8554872
RGD:7240710
frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bace2 beta-secretase 2 JBrowse link 11 37,798,397 37,880,624 RGD:13782172
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688398
RGD:8554872
RGD:11554173
RGD:5688721
RGD:5688716
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509588
RGD:8554872
RGD:11554173
RGD:5509612
RGD:5509609
RGD:5509602
RGD:5509589
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:5508418
RGD:8554872
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:1302531
RGD:8554872
RGD:11554173
RGD:10412702
RGD:10412699
RGD:8158108
RGD:7240710
G Marchf4 membrane associated ring-CH-type finger 4 JBrowse link 9 79,781,752 79,898,726 RGD:8554872
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:8554872
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:8554872
G Pou1f1 POU class 1 homeobox 1 JBrowse link 11 2,645,659 2,662,581 RGD:8554872
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:10412726
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:7240710
RGD:8554872
RGD:11554173
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:8554872
RGD:13592920
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:13592920
Frontotemporal Lobar Degeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:10059351
G Chmp2b charged multivesicular body protein 2B JBrowse link 11 2,666,405 2,692,213 RGD:5688397
RGD:11554173
RGD:5688712
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:5509902
RGD:9685710
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:10401634
RGD:11554173
RGD:10401650
RGD:10401647
RGD:10401638
RGD:10401637
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:10412651
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:6480505
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:11554173
G Sigmar1 sigma non-opioid intracellular receptor 1 JBrowse link 5 58,121,824 58,124,687 RGD:11554173
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687136
RGD:11554173
RGD:5687172
RGD:5687159
RGD:5687158
G Tmem106b transmembrane protein 106B JBrowse link 4 39,517,679 39,534,491 RGD:11554173
FTDALS1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RGD1359108 similar to RIKEN cDNA 3110043O21 JBrowse link 5 50,666,444 50,691,523 RGD:7240710
RGD:8554872
RGD:11554173
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:8554872
FTDALS2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 JBrowse link 20 13,665,046 13,666,845 RGD:7240710
RGD:8554872
FTDALS3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:7240710
RGD:8554872
FTDALS4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:8554872
RGD:7240710
GRN-related frontotemporal lobar degeneration with TDP43 inclusions term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:5509604
RGD:8554872
RGD:7240710
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:13592920
Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:7240710
RGD:8554872
Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:8554872
RGD:7240710
Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:7240710
RGD:8554872
inclusion body myopathy with Paget disease of bone and frontotemporal dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:10059681
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 JBrowse link 7 144,865,302 144,871,592 RGD:11554173
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 JBrowse link 4 81,237,496 81,241,281 RGD:10395280
RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10059681
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:11554173
Pick's disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:10047401
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:10047401
RGD:10047402
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:10047402
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:5509779
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:7495833
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:7240710
RGD:8554872
RGD:11554173
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:7240710
RGD:8554872
RGD:11554173
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480200
G Sncb synuclein, beta JBrowse link 17 10,384,472 10,392,776 RGD:6480200
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687194
Primary Progressive Nonfluent Aphasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      nervous system disease 10196
        neurodegenerative disease 2689
          TDP-43 Proteinopathies 226
            Frontotemporal Lobar Degeneration + 38
            amyotrophic lateral sclerosis + 207
Path 2
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      nervous system disease 10196
        central nervous system disease 8075
          neurodegenerative disease 2689
            TDP-43 Proteinopathies 226
              Frontotemporal Lobar Degeneration + 38
              amyotrophic lateral sclerosis + 207
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.