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ONTOLOGY REPORT - ANNOTATIONS


Term:Acute Lung Injury
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Accession:DOID:9004610 term browser browse the term
Definition:A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Synonyms:exact_synonym: Acute Lung Injuries
 primary_id: MESH:D055371;   RDO:0007706
For additional species annotation, visit the Alliance of Genome Resources.


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Acute Lung Injury term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:32716389
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:11554173
G Adar adenosine deaminase, RNA-specific JBrowse link 2 189,045,551 189,085,448 RGD:10755331
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:5686380
RGD:8695940
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:6480481
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:7244254
G Akap12 A-kinase anchoring protein 12 JBrowse link 1 40,816,130 40,906,582 RGD:14348970
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6483494
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:5509626
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:11554173
G Aqp5 aquaporin 5 JBrowse link 7 141,249,044 141,252,576 RGD:11553933
G Ascl1 achaete-scute family bHLH transcription factor 1 JBrowse link 7 28,038,662 28,040,504 RGD:11554173
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:10054109
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:10054109
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:11040808
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:34901874
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:13782288
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:13782288
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:11554173
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:10045573
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480432
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:68880
RGD:6480432
RGD:5683874
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:5688151
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6893505
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:5135253
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:5135247
RGD:11554173
RGD:5147925
RGD:5135253
G Cxcl6 C-X-C motif chemokine ligand 6 JBrowse link 14 18,860,201 18,920,839 RGD:5135247
RGD:5135256
G Cxcr2 C-X-C motif chemokine receptor 2 JBrowse link 9 81,427,275 81,435,065 RGD:7257703
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:5135235
RGD:5147744
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:5147744
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:34901874
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:11554173
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5131862
G Elane elastase, neutrophil expressed JBrowse link 7 12,638,320 12,640,168 RGD:10450548
RGD:10450587
RGD:10450585
G Ephx1 epoxide hydrolase 1 JBrowse link 13 99,271,390 99,300,580 RGD:11554173
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:5688354
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:34901874
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:7387313
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:11341740
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:11341811
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11554173
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:11554173
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:5147925
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:5147925
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link 13 89,329,298 89,343,916 RGD:5147925
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:7387313
G Flt1 Fms related receptor tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:5684427
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:8662452
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:13504847
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:7257562
G Gzmb granzyme B JBrowse link 15 35,413,862 35,417,293 RGD:5135517
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:4892587
RGD:34901874
RGD:10402098
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:5508470
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:4145326
RGD:4140418
G Hnrnpc heterogeneous nuclear ribonucleoprotein C JBrowse link 15 28,486,605 28,517,353 RGD:10054390
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:34901874
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:8547719
RGD:11554173
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480432
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:7364984
RGD:14975158
RGD:7365008
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:4145512
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:11554173
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655952
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:4142807
RGD:7204498
RGD:6480432
RGD:4142531
RGD:4143193
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:5144222
RGD:11554173
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:4143193
RGD:4143168
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480432
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:4888524
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:10402798
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11062103
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:36049795
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:6482199
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:11531100
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:5684427
G Mfn1 mitofusin 1 JBrowse link 2 118,929,738 118,971,689 RGD:12437080
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:12437080
G Mir155 microRNA 155 JBrowse link 11 24,176,603 24,176,667 RGD:21066348
RGD:21408593
RGD:24922218
RGD:11566124
G Mir223 microRNA 223 JBrowse link X 65,367,812 65,367,921 RGD:21408568
RGD:26884341
G Mir330 microRNA 330 JBrowse link 1 80,092,681 80,092,777 RGD:11553933
G Mir96 microRNA 96 JBrowse link 4 57,463,366 57,463,471 RGD:11553933
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:13207316
G Mmp7 matrix metallopeptidase 7 JBrowse link 8 5,893,253 5,900,965 RGD:9685338
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:13207316
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6909173
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:11554173
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:11554173
G Mylk myosin light chain kinase JBrowse link 11 69,013,060 69,260,039 RGD:1581052
RGD:11554173
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11554173
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:5144065
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:8547530
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5147744
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:7247713
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:11035223
RGD:13442501
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 11 74,717,600 74,793,902 RGD:12437080
G P2ry12 purinergic receptor P2Y12 JBrowse link 2 149,440,807 149,482,592 RGD:6480522
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:11533951
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:11075069
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:9835397
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:6483494
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:6482677
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:6482722
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:5147760
RGD:7241552
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:8553030
RGD:11554173
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:6484539
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:11100043
RGD:11250405
G Procr protein C receptor JBrowse link 3 151,285,321 151,289,581 RGD:13515130
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5135287
RGD:5135496
G Scgb1a1 secretoglobin family 1A member 1 JBrowse link 1 225,279,698 225,283,246 RGD:5143982
RGD:5144142
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:11035256
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11075078
RGD:11080967
RGD:11080962
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:8661650
G Sftpa1 surfactant protein A1 JBrowse link 16 18,716,019 18,719,404 RGD:4143451
G Sftpd surfactant protein D JBrowse link 16 18,753,535 18,766,100 RGD:11554173
G Slpi secretory leukocyte peptidase inhibitor JBrowse link 3 160,799,979 160,802,228 RGD:9999422
RGD:9999425
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:5147812
G Tacr1 tachykinin receptor 1 JBrowse link 4 113,247,236 113,416,139 RGD:5147819
G Tff1 trefoil factor 1 JBrowse link 20 9,892,124 9,895,984 RGD:11554173
G Tff2 trefoil factor 2 JBrowse link 20 9,872,669 9,876,008 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11554173
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:5131887
RGD:13515130
RGD:5685372
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:9999422
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:5135496
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480432
RGD:14995473
RGD:14975158
RGD:5147925
G Tnfaip6 TNF alpha induced protein 6 JBrowse link 3 37,545,238 37,564,704 RGD:11554173
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:11554173
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:5684427
G Vip vasoactive intestinal peptide JBrowse link 1 42,169,307 42,177,582 RGD:4145303
RGD:11554173
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:13209002

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16021
    Wounds and Injuries 824
      Thoracic Injuries 248
        Lung Injury 243
          Acute Lung Injury 127
Path 2
Term Annotations click to browse term
  disease 16021
    disease of anatomical entity 15274
      respiratory system disease 2658
        lower respiratory tract disease 1626
          lung disease 1584
            Lung Injury 243
              Acute Lung Injury 127
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.