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Term:Left Ventricular Hypertrophy
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Accession:DOID:9004616 term browser browse the term
Definition:Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Synonyms:exact_synonym: Increased Left Ventricular Wall Thickness;   Left Ventricular Hypertrophies
 primary_id: MESH:D017379
 alt_id: RDO:0007042
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Left Ventricular Hypertrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace2 angiotensin I converting enzyme 2 JBrowse link NW_004955519 2,591,229 2,643,705 RGD:9068941
G Acta1 actin alpha 1, skeletal muscle JBrowse link NW_004955492 8,644,696 8,647,412 RGD:9068941
G Adam17 ADAM metallopeptidase domain 17 JBrowse link NW_004955487 5,180,241 5,218,298 RGD:9068941
G Adgrl4 adhesion G protein-coupled receptor L4 JBrowse link NW_004955423 14,395,712 14,487,803 RGD:9068941
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link NW_004955420 20,911,181 20,922,992 RGD:9068941
G Adrb1 adrenoceptor beta 1 JBrowse link NW_004955431 19,025,663 19,027,026 RGD:9068941
G Adrb2 adrenoceptor beta 2 JBrowse link NW_004955415 5,515,157 5,517,198 RGD:9068941
G Adrb3 adrenoceptor beta 3 JBrowse link NW_004955463 13,663,064 13,665,553 RGD:9068941
G Ager advanced glycosylation end-product specific receptor JBrowse link NW_004955437 645,482 648,607 RGD:9068941
G Agt angiotensinogen JBrowse link NW_004955492 7,863,662 7,874,863 RGD:9068941
G Agtr1 angiotensin II receptor type 1 JBrowse link NW_004955474 8,733,942 8,781,305 RGD:9068941
G Agtr2 angiotensin II receptor type 2 JBrowse link NW_004955534 3,653,112 3,654,248 RGD:9068941
G Ahr aryl hydrocarbon receptor JBrowse link NW_004955410 20,428,531 20,459,482 RGD:9068941
G Atp5f1d ATP synthase F1 subunit delta JBrowse link NW_004955495 6,664,394 6,666,693 RGD:9068941
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link NW_004955407 25,601,253 25,609,933 RGD:9068941
G Bak1 BCL2 antagonist/killer 1 JBrowse link NW_004955437 2,036,415 2,041,997 RGD:9068941
G Bdkrb1 bradykinin receptor B1 JBrowse link NW_004955438 16,500,219 16,505,394 RGD:9068941
G Bdkrb2 bradykinin receptor B2 JBrowse link NW_004955438 16,514,300 16,537,160 RGD:9068941
G Bmp10 bone morphogenetic protein 10 JBrowse link NW_004955424 16,124,526 16,130,723 RGD:9068941
G Brd4 bromodomain containing 4 JBrowse link NW_004955495 7,959,033 7,989,216 RGD:9068941
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link NW_004955451 11,136,885 11,194,321 RGD:9068941
G Cat catalase JBrowse link NW_004955422 11,783,973 11,826,970 RGD:9068941
G Ccn2 cellular communication network factor 2 JBrowse link NW_004955436 12,523,602 12,526,986 RGD:9068941
G Cdkn1b cyclin dependent kinase inhibitor 1B JBrowse link NW_004955413 9,615,542 9,620,542 RGD:9068941
G Ckb creatine kinase B JBrowse link NW_004955538 2,379,868 2,380,771 RGD:9068941
G Ckm creatine kinase, M-type JBrowse link NW_004955555 2,318,072 2,330,733 RGD:9068941
G Col1a1 collagen type I alpha 1 chain JBrowse link NW_004955451 11,468,156 11,484,410 RGD:9068941
G Col3a1 collagen type III alpha 1 chain JBrowse link NW_004955403 9,720,831 9,758,019 RGD:9068941
G Coq7 coenzyme Q7, hydroxylase JBrowse link NW_004955442 3,026,458 3,033,582 RGD:9068941
G Crhr2 corticotropin releasing hormone receptor 2 JBrowse link NW_004955410 31,830,333 31,874,384 RGD:9068941
G Crot carnitine O-octanoyltransferase JBrowse link NW_004955607 379,121 413,394 RGD:9068941
G Ctnnb1 catenin beta 1 JBrowse link NW_004955420 29,030,716 29,047,447 RGD:9068941
G Dsc2 desmocollin 2 JBrowse link NW_004955402 18,465,631 18,496,948 RGD:9068941
G Dsp desmoplakin JBrowse link NW_004955465 6,356,970 6,391,206 RGD:9068941
G Dusp1 dual specificity phosphatase 1 JBrowse link NW_004955408 25,481,294 25,484,381 RGD:9068941
G Ece1 endothelin converting enzyme 1 JBrowse link NW_004955452 1,653,783 1,704,619 RGD:9068941
G Edn1 endothelin 1 JBrowse link NW_004955465 2,287,906 2,314,945 RGD:9068941
G Egfr epidermal growth factor receptor JBrowse link NW_004955456 321,222 456,431 RGD:9068941
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link NW_004955436 12,416,147 12,477,214 RGD:9068941
G Esr2 estrogen receptor 2 JBrowse link NW_004955466 5,587,003 5,644,765 RGD:9068941
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link NW_004955491 4,215,353 4,292,229 RGD:9068941
G Fn1 fibronectin 1 JBrowse link NW_004955457 629,599 694,948 RGD:9068941
G Foxo3 forkhead box O3 JBrowse link NW_004955411 33,655,958 33,770,829 RGD:9068941
G Fzd2 frizzled class receptor 2 JBrowse link NW_004955451 17,501,410 17,503,726 RGD:9068941
G Gaa glucosidase alpha, acid JBrowse link NW_004955506 2,764,959 2,783,231 RGD:9068941
G Gdf15 growth differentiation factor 15 JBrowse link NW_004955524 3,123,513 3,125,642 RGD:9068941
G Grk2 G protein-coupled receptor kinase 2 JBrowse link NW_004955422 18,173,438 18,192,357 RGD:9068941
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link NW_004955555 668,641 676,351 RGD:9068941
G Hbegf heparin binding EGF like growth factor JBrowse link NW_004955418 259,860 321,340 RGD:9068941
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 JBrowse link NW_004955495 7,124,060 7,143,730 RGD:9068941
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 JBrowse link NW_004955450 4,139,852 4,181,377 RGD:9068941
G Hrh2 histamine receptor H2 JBrowse link NW_004955408 28,186,316 28,225,146 RGD:9068941
G Jph2 junctophilin 2 JBrowse link NW_004955445 13,117,312 13,190,061 RGD:9068941
G Jup junction plakoglobin JBrowse link NW_004955451 15,993,055 16,004,152 RGD:9068941
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 JBrowse link NW_004955414 32,209,426 32,212,424 RGD:9068941
G Kcnk2 potassium two pore domain channel subfamily K member 2 JBrowse link NW_004955406 2,793,493 2,975,322 RGD:9068941
G Lepr leptin receptor JBrowse link NW_004955423 25,108,897 25,185,315 RGD:9068941
G Lifr LIF receptor subunit alpha JBrowse link NW_004955426 23,045,867 23,093,694 RGD:9068941
G Mef2c myocyte enhancer factor 2C JBrowse link NW_004955418 22,537,388 22,701,434 RGD:9068941
G Mmp2 matrix metallopeptidase 2 JBrowse link NW_004955433 13,024,844 13,050,041 RGD:9068941
G Mthfr methylenetetrahydrofolate reductase JBrowse link NW_004955486 2,096,379 2,112,240 RGD:9068941
G Mtor mechanistic target of rapamycin kinase JBrowse link NW_004955486 2,487,642 2,599,694 RGD:9068941
G Mybpc3 myosin binding protein C3 JBrowse link NW_004955422 888,529 902,074 RGD:9068941
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link NW_004955461 2,714,022 2,718,872 RGD:9068941
G Myl3 myosin light chain 3 JBrowse link NW_004955420 25,308,513 25,311,959 RGD:9068941
G Mypn myopalladin JBrowse link NW_004955425 20,461,654 20,545,626 RGD:9068941
G Ncl nucleolin JBrowse link NW_004955453 4,154,627 4,164,253 RGD:9068941
G Nexn nexilin F-actin binding protein JBrowse link NW_004955423 15,278,526 15,299,654 RGD:9068941
G Nfatc3 nuclear factor of activated T cells 3 JBrowse link NW_004955484 8,433,765 8,558,005 RGD:9068941
G Nfatc4 nuclear factor of activated T cells 4 JBrowse link NW_004955409 35,931,208 35,941,555 RGD:9068941
G Nos3 nitric oxide synthase 3 JBrowse link NW_004955491 5,438,228 5,457,308 RGD:9068941
G Nox4 NADPH oxidase 4 JBrowse link NW_004955414 4,062,337 4,220,032 RGD:9068941
G Nppa natriuretic peptide A JBrowse link NW_004955486 2,061,196 2,062,805 RGD:9068941
G Nppb natriuretic peptide B JBrowse link NW_004955486 2,054,775 2,056,130 RGD:9068941
G Npr1 natriuretic peptide receptor 1 JBrowse link NW_004955545 323,386 338,654 RGD:9068941
G Npy neuropeptide Y JBrowse link NW_004955410 26,348,388 26,355,232 RGD:9068941
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link NW_004955484 7,012,373 7,028,182 RGD:9068941
G Pamr1 peptidase domain containing associated with muscle regeneration 1 JBrowse link NW_004955422 10,734,673 10,913,258 RGD:9068941
G Pbrm1 polybromo 1 JBrowse link NW_004955430 2,536,086 2,671,094 RGD:9068941
G Pde1a phosphodiesterase 1A JBrowse link NW_004955403 14,906,069 15,202,710 RGD:9068941
G Pde2a phosphodiesterase 2A JBrowse link NW_004955414 18,765,591 18,826,717 RGD:9068941
G Pde3a phosphodiesterase 3A JBrowse link NW_004955413 16,340,827 16,642,731 RGD:9068941
G Plau plasminogen activator, urokinase JBrowse link NW_004955437 17,995,726 18,000,542 RGD:9068941
G Ppara peroxisome proliferator activated receptor alpha JBrowse link NW_004955413 30,306,563 30,366,245 RGD:9068941
G Pparg peroxisome proliferator activated receptor gamma JBrowse link NW_004955429 14,814,690 14,936,869 RGD:9068941
G Ppargc1a PPARG coactivator 1 alpha JBrowse link NW_004955480 543,397 1,188,376 RGD:9068941
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link NW_004955496 6,934,542 7,059,745 RGD:9068941
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link NW_004955437 18,323,852 18,377,815 RGD:9068941
G Ppp3r1 protein phosphatase 3 regulatory subunit B, alpha JBrowse link NW_004955424 16,624,214 16,690,783 RGD:9068941
G Ppp5c protein phosphatase 5 catalytic subunit JBrowse link NW_004955574 523,044 545,461 RGD:9068941
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link NW_004955491 5,852,534 6,048,820 RGD:9068941
G Prkca protein kinase C alpha JBrowse link NW_004955478 5,686,639 6,090,356 RGD:9068941
G Prkcb protein kinase C beta JBrowse link NW_004955493 2,395,494 2,710,522 RGD:9068941
G Prkcd protein kinase C delta JBrowse link NW_004955430 3,125,066 3,151,857 RGD:9068941
G Prkcz protein kinase C zeta JBrowse link NW_004955486 8,947,579 9,021,702 RGD:9068941
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link NW_004955439 18,664,230 19,953,358 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004955425 5,007,811 5,091,829 RGD:9068941
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link NW_004955406 25,077,988 25,086,259 RGD:9068941
G Pth parathyroid hormone JBrowse link NW_004955414 28,828,389 28,831,417 RGD:9068941
G Ptk2 protein tyrosine kinase 2 JBrowse link NW_004955461 14,337,914 14,622,779 RGD:9068941
G Ptk2b protein tyrosine kinase 2 beta JBrowse link NW_004955403 49,856,056 49,970,800 RGD:9068941
G Ptn pleiotrophin JBrowse link NW_004955494 5,580,264 5,681,848 RGD:9068941
G Ptprf protein tyrosine phosphatase receptor type F JBrowse link NW_004955537 3,096,601 3,185,682 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004955460 13,270,159 13,295,562 RGD:9068941
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link NW_004955500 6,655,056 6,674,311 RGD:9068941
G Rasa1 RAS p21 protein activator 1 JBrowse link NW_004955418 23,807,740 23,897,699 RGD:9068941
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link NW_004955422 19,602,930 19,612,263 RGD:9068941
G Ren renin JBrowse link NW_004955406 40,016,624 40,026,286 RGD:9068941
G Rhoa ras homolog family member A JBrowse link NW_004955532 1,300,821 1,347,453 RGD:9068941
G Rock1 Rho associated coiled-coil containing protein kinase 1 JBrowse link NW_004955402 9,752,101 9,864,317 RGD:9068941
G Rock2 Rho associated coiled-coil containing protein kinase 2 JBrowse link NW_004955487 5,856,190 5,972,408 RGD:9068941
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link NW_004955451 3,181,085 3,225,610 RGD:9068941
G Shc1 SHC adaptor protein 1 JBrowse link NW_004955545 1,468,391 1,479,209 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
G Slc25a4 solute carrier family 25 member 4 JBrowse link NW_004955403 23,878,329 23,882,322 RGD:9068941
G Slc9a1 solute carrier family 9 member A1 JBrowse link NW_004955452 6,409,833 6,467,841 RGD:9068941
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link NW_004955495 2,021,671 2,105,155 RGD:9068941
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 JBrowse link NW_004955491 5,653,284 5,657,546 RGD:9068941
G Stk11 serine/threonine kinase 11 JBrowse link NW_004955495 6,678,195 6,699,408 RGD:9068941
G Tgm2 transglutaminase 2 JBrowse link NW_004955445 18,544,192 18,576,576 RGD:9068941
G Thra thyroid hormone receptor alpha JBrowse link NW_004955451 14,731,746 14,743,545 RGD:9068941
G Thrb thyroid hormone receptor beta JBrowse link NW_004955430 15,992,146 16,322,696 RGD:9068941
G Tnnt2 troponin T2, cardiac type JBrowse link NW_004955406 37,491,462 37,507,360 RGD:9068941
G Ttn titin JBrowse link NW_004955403 18,057,344 18,328,389 RGD:9068941
G Ucn urocortin JBrowse link NW_004955469 9,277,637 9,278,641 RGD:9068941
G Vcam1 vascular cell adhesion molecule 1 JBrowse link NW_004955435 5,390,745 5,410,025 RGD:9068941
Fabry Disease, Cardiac Variant term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gla galactosidase alpha JBrowse link NW_004955503 7,526,077 7,535,817 RGD:9068941

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  disease 11744
    Pathological Conditions, Signs and Symptoms 6852
      Anatomical Pathological Conditions 1203
        Hypertrophy 550
          Cardiomegaly 479
            Left Ventricular Hypertrophy 127
              Fabry Disease, Cardiac Variant 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.