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ONTOLOGY REPORT - ANNOTATIONS


Term:Left Ventricular Hypertrophy
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Accession:DOID:9004616 term browser browse the term
Definition:Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Synonyms:exact_synonym: Increased Left Ventricular Wall Thickness;   Left Ventricular Hypertrophies
 primary_id: MESH:D017379
 alt_id: RDO:0007042
For additional species annotation, visit the Alliance of Genome Resources.


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Left Ventricular Hypertrophy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:1331525
RGD:12880015
RGD:12879391
RGD:11554173
RGD:11038918
RGD:8157600
RGD:8142350
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:9685455
G Acta1 actin, alpha 1, skeletal muscle JBrowse link 19 56,674,072 56,677,084 RGD:11554173
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:13703040
G Adgrl4 adhesion G protein-coupled receptor L4 JBrowse link 2 256,609,787 256,724,642 RGD:13838662
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:5686385
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:7241557
RGD:7241563
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1601120
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:11554173
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:7243956
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:11554173
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1601151
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:11554173
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:11554173
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:13792675
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link 11 24,286,806 24,294,419 RGD:11085539
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:2316133
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:704379
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:704379
G Bmp10 bone morphogenetic protein 10 JBrowse link 4 119,224,906 119,230,534 RGD:2302083
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:9586348
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:2316207
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:5130755
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:2314476
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:2293630
G Ckb creatine kinase B JBrowse link 6 136,142,956 136,145,838 RGD:11554173
G Ckm creatine kinase, M-type JBrowse link 1 80,321,507 80,331,841 RGD:11554173
G Cma1 chymase 1 JBrowse link 15 34,601,037 34,603,819 RGD:5128600
RGD:11554173
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:11554173
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:11554173
G Coq7 coenzyme Q7, hydroxylase JBrowse link 1 188,176,060 188,190,874 RGD:2313649
G Crhr2 corticotropin releasing hormone receptor 2 JBrowse link 4 85,286,371 85,329,374 RGD:1642796
G Crot carnitine O-octanoyltransferase JBrowse link 4 22,079,837 22,116,265 RGD:1599987
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6907433
G Ctf1 cardiotrophin 1 JBrowse link 1 199,162,319 199,168,296 RGD:69823
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:11554173
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4145630
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:4891151
RGD:4891150
G Dsc2 desmocollin 2 JBrowse link 18 11,826,705 11,858,801 RGD:8554872
G Dsp desmoplakin JBrowse link 17 27,286,811 27,334,453 RGD:8554872
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:7771584
G Ece1 endothelin converting enzyme 1 JBrowse link 5 156,215,469 156,318,652 RGD:7244172
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:8661692
RGD:11554173
RGD:8662288
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:1580955
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:6906934
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:1581013
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:9588322
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:11554173
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:2293330
G Fzd2 frizzled class receptor 2 JBrowse link 10 90,550,147 90,552,057 RGD:4107053
G Gaa glucosidase, alpha, acid JBrowse link 10 108,395,873 108,412,999 RGD:11554173
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:11554173
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:1625786
RGD:11534182
RGD:13513977
RGD:737775
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:10401823
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:11554173
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 JBrowse link 7 12,851,730 12,870,087 RGD:9693689
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:9693689
G Jph2 junctophilin 2 JBrowse link 3 159,709,998 159,776,536 RGD:8554872
G Jup junction plakoglobin JBrowse link 10 88,280,517 88,307,451 RGD:8554872
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 JBrowse link 1 102,103,093 102,107,134 RGD:7297042
G Kcnk2 potassium two pore domain channel subfamily K member 2 JBrowse link 13 107,690,111 107,886,476 RGD:9831114
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:5129122
G Lifr LIF receptor subunit alpha JBrowse link 2 56,424,910 56,489,346 RGD:1581858
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:5131608
G Mir30a microRNA 30a JBrowse link 9 29,542,635 29,542,705 RGD:11561904
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:8657108
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:14696732
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1582609
RGD:11554173
G Mybpc3 myosin binding protein C, cardiac JBrowse link 3 79,940,509 79,958,731 RGD:8554872
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:11554173
G Myh6 myosin heavy chain 6 JBrowse link 15 33,605,653 33,629,730 RGD:12792940
RGD:12792943
G Myh7 myosin heavy chain 7 JBrowse link 15 33,605,769 33,657,761 RGD:12792943
RGD:8554872
G Myl3 myosin light chain 3 JBrowse link 8 119,030,852 119,036,996 RGD:8554872
G Mypn myopalladin JBrowse link 20 26,988,820 27,074,106 RGD:8554872
G Ncl nucleolin JBrowse link 9 93,369,119 93,377,643 RGD:9686390
G Nexn nexilin (F actin binding protein) JBrowse link 2 257,452,937 257,484,607 RGD:8554872
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:1579956
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:1579956
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:7794715
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:13703040
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:1580154
RGD:11554173
RGD:7297044
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:1642202
RGD:7297044
RGD:1580154
G Npr1 natriuretic peptide receptor 1 JBrowse link 2 189,840,403 189,857,032 RGD:1580154
G Npy neuropeptide Y JBrowse link 4 79,557,856 79,565,059 RGD:7175091
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:11035227
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:9586349
G Pde1a phosphodiesterase 1A JBrowse link 3 66,803,247 67,263,658 RGD:2312523
G Pde2a phosphodiesterase 2A JBrowse link 1 166,534,643 166,626,158 RGD:2312523
G Pde3a phosphodiesterase 3A JBrowse link 4 175,431,904 175,703,844 RGD:2312523
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:7241205
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:1580229
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:2301893
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:7297042
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:1579956
RGD:11554173
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1579956
RGD:1580706
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:1580708
RGD:11554173
RGD:1580706
G Ppp5c protein phosphatase 5, catalytic subunit JBrowse link 1 78,944,054 78,968,361 RGD:8693745
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:8554872
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1581273
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:1581275
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1581272
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:1581275
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:13432569
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1581281
RGD:12801498
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:2300276
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7242699
RGD:7242899
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:729831
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642607
G Ptn pleiotrophin JBrowse link 4 64,239,156 64,330,996 RGD:10043833
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1581295
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:9835365
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:9999450
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:2298779
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6771379
RGD:11554173
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1642807
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1642807
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1642807
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:11554173
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:1643176
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:9495934
RGD:2293330
G Slc25a4 solute carrier family 25 member 4 JBrowse link 16 49,266,903 49,270,698 RGD:1580618
RGD:8554872
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:6771336
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:9586349
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 JBrowse link 4 7,076,710 7,108,334 RGD:9586349
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:11554173
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:1302539
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:2314321
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:2314321
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:1580232
RGD:8554872
G Ttn titin JBrowse link 3 63,565,160 63,837,815 RGD:8554872
G Ucn urocortin JBrowse link 6 26,602,144 26,602,974 RGD:1642796
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:1580350
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:7247645

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  disease 15619
    Pathological Conditions, Signs and Symptoms 8030
      Anatomical Pathological Conditions 1329
        Hypertrophy 705
          Cardiomegaly 625
            Left Ventricular Hypertrophy 177
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.