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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Acute-Phase Reaction
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Accession:DOID:9004713 term browser browse the term
Definition:An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.
Synonyms:exact_synonym: Acute Phase State;   Acute-Phase Response
 primary_id: MESH:D000210;   RDO:0004732
For additional species annotation, visit the Alliance of Genome Resources.


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Acute-Phase Reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang angiogenin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9464241 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Ass1 argininosuccinate synthase 1 IEP RGD PMID:15698416 RGD:1599305 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha IEP RGD PMID:16172914 RGD:1625368 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IEP mRNA:increased expression:liver RGD PMID:8051100 RGD:1599745 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Epo erythropoietin IEP mRNA, protein:increased expression:multiple RGD PMID:19840250 RGD:10395370 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP mRNA, protein:increased expression:liver RGD PMID:19840250 RGD:10395370 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment ISO associated with Burns RGD PMID:10714634 RGD:10402777 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il6 interleukin 6 ISO human protein in a rat model RGD PMID:7678052 RGD:11060262 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor IEP mRNA:increased expression:liver RGD PMID:2174054 RGD:729416 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Mc1r melanocortin 1 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mc2r melanocortin 2 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
JBrowse link
G Mc3r melanocortin 3 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr 3:170,252,901...170,253,998
Ensembl chr 3:170,252,901...170,253,998
JBrowse link
G Mc4r melanocortin 4 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Mc5r melanocortin 5 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr18:64,113,659...64,118,700
Ensembl chr18:64,114,933...64,116,524
JBrowse link
G Mt1 metallothionein 1 IEP protein:increased expression:liver (rat) RGD PMID:10535526 RGD:6484135 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A IEP protein:increased expression:liver (rat) RGD PMID:10535526 RGD:6484135 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IEP mRNA:decreased expression:liver RGD PMID:20949361 RGD:10412679 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta IDA RGD PMID:17461989 RGD:2324886 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Stat5b signal transducer and activator of transcription 5B IDA protein:decreased activity:liver RGD PMID:17565389 RGD:2291935 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tf transferrin IEP RGD PMID:17417667 RGD:1601529 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor IEP RGD PMID:17417667 RGD:1601529 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    Pathological Conditions, Signs and Symptoms 8754
      Pathologic Processes 6130
        Inflammation 2172
          Acute-Phase Reaction 22
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.