ONTOLOGY REPORT - ANNOTATIONS


Term:Brain Hypoxia
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Accession:DOID:9004756 term browser browse the term
Definition:A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
Synonyms:exact_synonym: Anoxic Brain Damage;   Anoxic Encephalopathies;   Anoxic Encephalopathy;   Brain Anoxia;   Cerebral Anoxia;   Cerebral Hypoxia;   Hypoxic Brain Damage;   Hypoxic Encephalopathies;   Hypoxic Encephalopathy
 primary_id: MESH:D002534;   RDO:0005159
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Brain Hypoxia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam15 ADAM metallopeptidase domain 15 JBrowse link 2 188,661,831 188,672,337 RGD:13703065
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:13703065
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:2311713
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10400899
RGD:10401067
G Epor erythropoietin receptor JBrowse link 8 22,969,737 22,974,468 RGD:10401067
RGD:10400899
G Gjb6 gap junction protein, beta 6 JBrowse link 15 37,400,888 37,411,656 RGD:7364784
G Gjd2 gap junction protein, delta 2 JBrowse link 3 105,467,480 105,470,475 RGD:7364784
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:6893269
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6482794
RGD:11554173
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:6482794
RGD:11554173
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:7794714
G Pam peptidylglycine alpha-amidating monooxygenase JBrowse link 9 111,028,543 111,177,588 RGD:6483514
Chronic Intermittent Hypoxia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:11039031
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:11039031
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:13792505
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:13792505
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561988
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:11561988
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:13792505
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:11353961
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:11353961
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:13793400
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:11561988
Hypoxia-Ischemia, Brain term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adnp activity-dependent neuroprotector homeobox JBrowse link 3 164,937,188 164,964,819 RGD:2312775
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:6903872
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:2313021
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:10053564
RGD:13524865
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:10043348
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:10054502
RGD:13782292
G Bcan brevican JBrowse link 2 187,359,674 187,373,133 RGD:14392799
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:10054502
RGD:13782292
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:10053669
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6483050
RGD:11558017
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:8699519
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:13782359
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:2311455
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:2311455
RGD:13782359
RGD:13782292
RGD:13782279
RGD:10054502
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:13782292
RGD:13782359
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:13782359
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:5683321
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:9068474
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549543
G Ccr2 C-C motif chemokine receptor 2 RGD:4144890
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:4890442
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 JBrowse link 10 67,862,054 67,863,255 RGD:13782373
G Clock clock circadian regulator JBrowse link 14 34,418,226 34,502,218 RGD:10043348
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase JBrowse link 10 88,490,798 88,497,357 RGD:6483337
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:9585994
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:2311381
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:9587791
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:9588620
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:2289081
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:10395352
G Epha4 Eph receptor A4 JBrowse link 9 83,111,222 83,253,486 RGD:5688765
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10400911
RGD:10401072
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha JBrowse link 15 19,619,947 19,655,381 RGD:632668
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:13782292
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:9587791
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:10402203
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:2315620
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:2325954
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:2325954
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:2325954
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 JBrowse link 2 50,099,576 50,499,799 RGD:9686395
G Hdac3 histone deacetylase 3 JBrowse link 18 31,073,057 31,094,347 RGD:9588620
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:9068873
RGD:11554173
RGD:9068901
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10766440
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:7257595
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:8549456
RGD:12904932
RGD:10046049
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:5510005
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:10402756
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7204438
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:12792241
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:11554173
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 7 135,803,723 135,831,006 RGD:11554173
G Ireb2 iron responsive element binding protein 2 JBrowse link 8 59,450,974 59,503,634 RGD:12903962
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:5684383
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:11558017
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:6483088
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:9587791
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:13782373
G Mbd2 methyl-CpG binding domain protein 2 JBrowse link 18 65,814,026 65,885,115 RGD:9588620
G Mbp myelin basic protein JBrowse link 18 79,326,738 79,437,310 RGD:7327196
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:8694100
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:11554173
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:5684358
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:10449494
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6483831
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:2316117
RGD:6483831
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B JBrowse link 10 86,303,727 86,312,770 RGD:13515077
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 JBrowse link 1 103,197,918 103,258,309 RGD:9835021
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 JBrowse link 4 49,941,046 50,140,764 RGD:9590116
G Rnf146 ring finger protein 146 JBrowse link 1 30,856,923 30,873,814 RGD:13524865
G S100b S100 calcium binding protein B JBrowse link 20 13,130,633 13,142,856 RGD:5508819
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:2316117
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:6771331
G Spi1 Spi-1 proto-oncogene JBrowse link 3 79,918,127 79,937,708 RGD:9586724
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:11038672
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:7244383
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:2302400
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11554173
Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pnpo pyridoxamine 5'-phosphate oxidase JBrowse link 10 84,874,926 84,881,190 RGD:7240710
RGD:8554872

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  disease 14875
    disease of anatomical entity 14051
      nervous system disease 9116
        central nervous system disease 6913
          brain disease 6418
            Brain Hypoxia 95
              Chronic Intermittent Hypoxia 11
              Hypoxia-Ischemia, Brain + 79
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.