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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Vascular Remodeling
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Accession:DOID:9004771 term browser browse the term
Definition:The active alterations of vascular wall structures, often leading to elevated VASCULAR RESISTANCE. It is associated with AGING; ATHEROSCLEROSIS; DIABETES MELLITUS; HYPERTENSION; PREGNANCY; PULMONARY HYPERTENSION; and STROKE, but is also a normal part of EMBRYOGENESIS.
Synonyms:exact_synonym: Pulmonary Arterial Remodeling;   Pulmonary Arterial Remodelings;   Vascular Remodelings
 primary_id: MESH:D066253;   RDO:0015992
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Vascular Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor, type II-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26540443 NCBI chr15:101,128,522...101,145,336
Ensembl chr15:101,128,522...101,145,336
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO CTD Direct Evidence: marker/mechanism CTD PMID:25259750, PMID:27678262 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27678262 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Egfr epidermal growth factor receptor treatment ISO RGD PMID:31264901 RGD:38599217 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 6:88,193,891...88,207,032
Ensembl chr 6:88,193,891...88,207,032
JBrowse link
G Mir125a microRNA 125a treatment ISO RGD PMID:29700287 RGD:26884455 NCBI chr17:17,830,812...17,830,879
Ensembl chr17:17,830,812...17,830,879
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr15:98,038,744...98,093,569
Ensembl chr15:98,038,744...98,093,744
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment IDA RGD PMID:26856544 RGD:11073690 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 ISO protein:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chr12:33,957,671...33,959,831
Ensembl chr12:33,957,671...33,959,829
JBrowse link
G Vim vimentin ISO protein:increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chr 2:13,574,311...13,582,826
Ensembl chr 2:13,573,927...13,582,826
JBrowse link
Aortic Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO associated with Hypertension RGD PMID:26693246 RGD:11073698 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13427
    Pathological Conditions, Signs and Symptoms 8020
      Anatomical Pathological Conditions 1449
        Vascular Remodeling 10
          Aortic Remodeling 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.