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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Vascular Remodeling
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Accession:DOID:9004771 term browser browse the term
Definition:The active alterations of vascular wall structures, often leading to elevated VASCULAR RESISTANCE. It is associated with AGING; ATHEROSCLEROSIS; DIABETES MELLITUS; HYPERTENSION; PREGNANCY; PULMONARY HYPERTENSION; and STROKE, but is also a normal part of EMBRYOGENESIS.
Synonyms:exact_synonym: Pulmonary Arterial Remodeling;   Pulmonary Arterial Remodelings;   Vascular Remodelings
 primary_id: MESH:D066253;   RDO:0015992
For additional species annotation, visit the Alliance of Genome Resources.


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Vascular Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26540443 NCBI chr 5:17,267,483...17,284,155
Ensembl chr 5:17,263,907...17,286,276
JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:25259750, PMID:27678262 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27678262 NCBI chr15:120,219,657...120,230,203 JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:31264901 RGD:38599217 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,478,882
JBrowse link
G GATA2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr13:71,981,139...71,997,626
Ensembl chr13:71,984,063...71,997,622
JBrowse link
G MIR125A microRNA mir-125a treatment ISO RGD PMID:29700287 RGD:26884455 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
JBrowse link
G SENP1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 5:78,419,849...78,476,315
Ensembl chr 5:78,423,383...78,476,195
JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO RGD PMID:26856544 RGD:11073690 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 ISO protein:increased expression:lung RGD PMID:25593290 RGD:38500244 NCBI chr 9:88,286,911...88,290,131 JBrowse link
G VIM vimentin ISO protein:increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chr10:43,516,441...43,526,172
Ensembl chr10:43,517,307...43,526,172
JBrowse link
Aortic Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SERPINE1 serpin family E member 1 treatment ISO associated with Hypertension RGD PMID:26693246 RGD:11073698 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12641
    Pathological Conditions, Signs and Symptoms 7581
      Anatomical Pathological Conditions 1349
        Vascular Remodeling 10
          Aortic Remodeling 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.