ONTOLOGY REPORT - ANNOTATIONS


Term:Cushing syndrome
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Accession:DOID:9005158 term browser browse the term
Definition:A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Synonyms:exact_synonym: Cushing syndrome;   Cushing's syndrome;   hypercortisolism
 primary_id: MESH:D003480
 alt_id: DOID:12252;   RDO:0005304
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Cushing syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:11554173
G Gabra6 gamma-aminobutyric acid type A receptor alpha 6 subunit JBrowse link 10 27,847,447 27,862,896 RGD:1626491
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:8554872
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:7174715
RGD:7174723
RGD:7174722
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:11554173
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha JBrowse link 10 97,940,705 97,959,199 RGD:1581269
RGD:11554173
ACTH-Independent Macronodular Adrenal Hyperplasia 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Armc5 armadillo repeat containing 5 JBrowse link 1 199,655,069 199,662,419 RGD:11554173
G Gcgr glucagon receptor JBrowse link 10 109,707,863 109,716,253 RGD:11554173
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:7240710
RGD:8554872
RGD:11568052
ACTH-Independent Macronodular Adrenal Hyperplasia 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Armc5 armadillo repeat containing 5 JBrowse link 1 199,655,069 199,662,419 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14823
    syndrome 4218
      Cushing syndrome 8
        ACTH-Independent Macronodular Adrenal Hyperplasia 1 3
        ACTH-Independent Macronodular Adrenal Hyperplasia 2 1
        ectopic Cushing syndrome 0
Path 2
Term Annotations click to browse term
  disease 14823
    disease of anatomical entity 13997
      endocrine system disease 4666
        adrenal gland disease 145
          adrenal cortex disease 77
            adrenal gland hyperfunction 30
              Cushing syndrome 8
                ACTH-Independent Macronodular Adrenal Hyperplasia 1 3
                ACTH-Independent Macronodular Adrenal Hyperplasia 2 1
                ectopic Cushing syndrome 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.