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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hepatic Porphyrias
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Accession:DOID:9005584 term browser browse the term
Definition:A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
Synonyms:exact_synonym: Hepatic Porphyria
 primary_id: MESH:D017094;   RDO:0007027
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Hepatic Porphyrias term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IEP
ISO
protein:increased activity:liver (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:1905639, PMID:3684400, PMID:6721832 RGD:4144806 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Cpox coproporphyrinogen oxidase IEP protein:decreased activity:liver, mitochondrial inner membrane (rat) RGD PMID:19482825 RGD:4144824 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Fech ferrochelatase IEP protein:increased activity:liver (rat) RGD PMID:6721832 RGD:4144806 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Hmbs hydroxymethylbilane synthase IEP protein:increased activity:liver (rat) RGD PMID:6721832 RGD:4144806 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ppox protoporphyrinogen oxidase ISO DNA:transition:cds:p.R59W (human)
DNA:missense mutation:cds:p.G232R (human)
protein:decreased activity:liver, kidney (mouse)
DNA:mutations:cds:multiple (human)
RGD PMID:9254745, PMID:8852667, PMID:9431441, PMID:10486317 RGD:1599174, RGD:1599172, RGD:4145281, RGD:1599176 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Urod uroporphyrinogen decarboxylase ISO
IEP
protein:decreased activity:liver (mouse)
ClinVar Annotator: match by term: Porphyria, hepatic
protein:decreased activity:liver (rat)
ClinVar PMID:2892774, PMID:2920211, PMID:3775362, PMID:7706766, PMID:8644733, PMID:23545314, PMID:3271868, PMID:6721832 RGD:4145290, RGD:4144806 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
acute intermittent porphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas2 5'-aminolevulinate synthase 2 ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:23650938 RGD:18337288 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 ISO ClinVar Annotator: match by term: Hydroxymethylbilane Synthase Deficiency
ClinVar Annotator: match by term: Acute intermittent porphyria
ClinVar PMID:18414213, PMID:25741868, PMID:28492532 NCBI chr 8:48,657,779...48,664,531
Ensembl chr 8:48,657,795...48,664,860
JBrowse link
G Hmbs hydroxymethylbilane synthase severity
treatment
susceptibility
ISO ClinVar Annotator: match by term: Abnormality of the heme biosynthetic pathway
ClinVar Annotator: match by term: Acute intermittent porphyria
ClinVar Annotator: match by term: Porphyria, Swedish type
DNA:mutations:multiple
DNA:mutations:multiple
DNA:splice-site mutation, missense mutation:intron 9, exon 10: IVS9-1G>A, p.R201W (human)
DNA:missense mutation:cds: p.R167Q (c.500G>A) (mouse)
DNA:missense mutation:exon 10: p.R173W (173C>T) (human)
human mRNA in a mouse model
DNA:deletion:exon 12:669-698del (p.E223_L232del) (human)
DNA:SNPs, deletion, haplotype:multiple
DNA:missense mutation:cds: p.V215M (human)
human gene in a mouse model
DNA:SNPs, haplotype:multiple
DNA:missense mutation:exon 10: p.R173W (c.517C>T) (human)
DNA:transversion:intron:IVS11-3C>G (human)
DNA:missense mutation:cd: p.A330P (human)
ClinVar Annotator: match by term: Hydroxymethylbilane Synthase Deficiency
ClinVar Annotator: match by OMIM:176000
CTD Direct Evidence: marker/mechanism
DNA:transition, transversions:intron:IVS1+1G>A, +2T>A, +5C>G (human)
ClinVar
CTD
OMIM
PMID:1301948, PMID:1427766, PMID:1496994, PMID:1577472, PMID:1714233, PMID:1961762, PMID:2025226, PMID:2227955, PMID:2243128, PMID:2789372, PMID:2864531, PMID:6132132, PMID:7757070, PMID:7962538, PMID:8081367, PMID:8096492, PMID:8262514, PMID:8262523, PMID:8270254, PMID:8270256, PMID:8401516, PMID:8772850, PMID:9199558, PMID:9225970, PMID:9281416, PMID:10408772, PMID:10494093, PMID:10502788, PMID:11055586, PMID:11831862, PMID:12357456, PMID:12372055, PMID:12566739, PMID:12773194, PMID:14970743, PMID:15003823, PMID:15469427, PMID:15534187, PMID:15643298, PMID:16211556, PMID:16817012, PMID:17298217, PMID:18414213, PMID:18627369, PMID:19138865, PMID:19292878, PMID:19460837, PMID:19656453, PMID:19694018, PMID:20978940, PMID:23815679, PMID:24997713, PMID:25637381, PMID:25741868, PMID:26075277, PMID:26095755, PMID:26582343, PMID:27507172, PMID:27539938, PMID:27558376, PMID:27849156, PMID:27884173, PMID:28492532, PMID:30311386, PMID:32581362, PMID:8563760, PMID:24997713, PMID:30385147, PMID:8270256, PMID:30615115, PMID:26071363, PMID:10453740, PMID:9455613, PMID:30297912, PMID:15469427, PMID:14757946, PMID:19138865, PMID:19656452, PMID:28990424, PMID:19656453, PMID:9523350, PMID:10667475, PMID:25870942, PMID:19664584, PMID:9860299 RGD:4145271, RGD:19165346, RGD:21079461, RGD:19165358, RGD:21079460, RGD:21079459, RGD:21079458, RGD:21079457, RGD:21079456, RGD:21079455, RGD:21079454, RGD:21079453, RGD:19165351, RGD:21079452, RGD:19165352, RGD:19165353, RGD:21079451, RGD:21079450, RGD:21079449, RGD:4144787 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Ppox protoporphyrinogen oxidase ISO DNA:missense mutation:exon:p.R59W (mouse) RGD PMID:11929050 RGD:4145363 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
Acute Intermittent Porphyria, Nonerythroid Variant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase ISO ClinVar Annotator: match by null ClinVar PMID:2511016, PMID:2563167, PMID:2915972, PMID:7962538, PMID:9199558, PMID:9860299, PMID:10343207, PMID:11071386 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
ALAD-Deficiency Porphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase ISO ClinVar Annotator: match by term: Porphyria, acute hepatic, digenic
ClinVar Annotator: match by term: Porphobilinogen synthase deficiency
ClinVar Annotator: match by OMIM:612740
OMIM
ClinVar
PMID:513604, PMID:1569184, PMID:1716854, PMID:1905639, PMID:2063868, PMID:3684400, PMID:10519994, PMID:15303011, PMID:16398658, PMID:17236137, PMID:24033266, PMID:28492532 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IEP protein:increased expression:liver RGD PMID:23390166 RGD:10449130 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
Coproporphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase ISO ClinVar Annotator: match by null
ClinVar Annotator: match by term: Coproporphyria
protein:decreased activity:liver (mouse)
ClinVar Annotator: match by term: Coproporphyria, digenic
ClinVar PMID:7987309, PMID:8159699, PMID:8286403, PMID:8990017, PMID:9843038, PMID:11309681, PMID:12181641, PMID:12227458, PMID:16398658, PMID:27959697, PMID:28492532, PMID:2079105 RGD:19165350 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
erythropoietic protoporphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 ISS OMIM:177000 | OMIM:300752 MouseDO NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 ISS OMIM:177000 | OMIM:300752 MouseDO NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Areg amphiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19267999 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Btc betacellulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19267999 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Ereg epiregulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19267999 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Fech ferrochelatase ISO CTD Direct Evidence: marker/mechanism|therapeutic
DNA:mutations:exons:
DNA:mutation:introns:IVS3-48C(human)
DNA:mutations:introns:IVS-48C,IVS1-23T(human)
CTD PMID:10464147, PMID:12950064, PMID:15284838, PMID:15793285, PMID:17600043, PMID:29906468, PMID:19787086, PMID:10942404, PMID:26280465, PMID:26789144 RGD:14700889, RGD:14700886, RGD:14700883, RGD:11556165 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
Erythropoietic Protoporphyria 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase ISO ClinVar Annotator: match by term: Protoporphyria, erythropoietic, 1 OMIM
ClinVar
PMID:1376018, PMID:1729699, PMID:1755842, PMID:3047929, PMID:3940245, PMID:7910885, PMID:8481408, PMID:8500787, PMID:9649563, PMID:11753383, PMID:12063482, PMID:14669009, PMID:15286165, PMID:16385445, PMID:16844398, PMID:17875872, PMID:18787536, PMID:19298273, PMID:23364466, PMID:24033266, PMID:25741868, PMID:26280465, PMID:28054335, PMID:28093505, PMID:28492532, PMID:30311386 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
Erythropoietic Protoporphyria 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X ISO ClinVar Annotator: match by term: PROTOPORPHYRIA, ERYTHROPOIETIC, 2 ClinVar
OMIM
PMID:25741868, PMID:28874591 NCBI chr 8:70,789,137...70,843,133
Ensembl chr 8:70,789,256...70,843,123
JBrowse link
G Fech ferrochelatase ISO ClinVar Annotator: match by term: Autosomal erythropoietic protoporphyria ClinVar PMID:11753383, PMID:14669009, PMID:16385445, PMID:17875872, PMID:20105171, PMID:23364466, PMID:24033266, PMID:25741868, PMID:26280465, PMID:28054335, PMID:28093505, PMID:30311386 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
Erythropoietic Protoporphyria, X-Linked Dominant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas2 5'-aminolevulinate synthase 2 disease_progression ISO DNA:deletions:exon: c.1699-1700delAT, c.1706-1709delAGTG (human)
ClinVar Annotator: match by OMIM:300752
OMIM
ClinVar
PMID:18760763, PMID:23263862, PMID:18760763, PMID:23263862 RGD:18337287, RGD:18337286 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
Harderoporphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase ISO ClinVar Annotator: match by null
ClinVar Annotator: match by term: Harderoporphyria
protein:altered activity:blood, lymphocyte (human)
ClinVar
OMIM
PMID:6886003, PMID:7757079, PMID:7987309, PMID:8286403, PMID:9454777, PMID:16159891, PMID:21103937, PMID:6886003 RGD:25671431 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
hepatoerythropoietic porphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Urod uroporphyrinogen decarboxylase ISO ClinVar Annotator: match by term: Porphyria, Hepatoerythropoietic
ClinVar Annotator: match by term: Hepatoerythropoietic porphyria
ClinVar PMID:1634232, PMID:1905636, PMID:2892774, PMID:2920211, PMID:3775362, PMID:7706766, PMID:8644733, PMID:23545314, PMID:25741868 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
hereditary coproporphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpox coproporphyrinogen oxidase ISO ClinVar Annotator: match by term: Hereditary coproporphyria
DNA:missense mutations:exons:multiple
DNA:missense mutations, nonsense mutation:exons:multiple
DNA:mutations:multiple
DNA:missense mutations, deletion, frameshift mutation:multiple
ClinVar Annotator: match by OMIM:121300
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:11309681, PMID:11831056, PMID:12181641, PMID:27959697, PMID:28492532, PMID:12181641, PMID:15896662, PMID:9888388, PMID:30385147 RGD:25671430, RGD:25671429, RGD:25671428, RGD:21079461 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
porphyria cutanea tarda term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase treatment ISO protein:decreased activity:blood, erythrocyte RGD PMID:526041, PMID:8100994 RGD:12904671, RGD:12904682 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Cpox coproporphyrinogen oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11831056 NCBI chr11:44,039,665...44,049,648
Ensembl chr11:44,039,669...44,049,648
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO RGD PMID:14714565 RGD:11576310 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11153915, PMID:20957336 RGD:11576316 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Gstm1 glutathione S-transferase mu 1 susceptibility ISO DNA:deletion:: (human) RGD PMID:20957336 RGD:11576316 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Hfe homeostatic iron regulator no_association
susceptibility
ISO ClinVar Annotator: match by term: UROPORPHYRINOGEN DECARBOXYLASE DEFICIENCY
CTD Direct Evidence: marker/mechanism
DNA:missense mutations: :p.H63D, p.C282Y (human)
DNA:missense mutations:cds:p.C282Y, p.H63D (human)
ClinVar
CTD
OMIM
PMID:8696333, PMID:8896550, PMID:8943161, PMID:9106528, PMID:9162021, PMID:9356458, PMID:9462220, PMID:11358905, PMID:11399207, PMID:11423500, PMID:11479183, PMID:11532995, PMID:11812557, PMID:11874997, PMID:11904676, PMID:12429850, PMID:12622622, PMID:12885340, PMID:14673107, PMID:15347835, PMID:15858186, PMID:16132052, PMID:17600748, PMID:18199861, PMID:18566337, PMID:19159930, PMID:19554541, PMID:20301613, PMID:24033266, PMID:24729993, PMID:25741868, PMID:26365338, PMID:28443246, PMID:28492532, PMID:28617828, PMID:30291871, PMID:30311386, PMID:31220083, PMID:11134514, PMID:27661980, PMID:17137171, PMID:19001803 RGD:7207253, RGD:14701050, RGD:8694367, RGD:8694347 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Urod uroporphyrinogen decarboxylase ISO
IEP
DNA:missense mutation:cds:p.G281V (human)
ClinVar Annotator: match by term: UROPORPHYRINOGEN DECARBOXYLASE DEFICIENCY
ClinVar Annotator: match by term: Porphyria cutanea tarda
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by OMIM:176100
ClinVar Annotator: match by null
protein:decreased activity:liver (human)
protein:decreased activity:liver (rat)
ClinVar
CTD
OMIM
PMID:2243121, PMID:2892774, PMID:2920211, PMID:3775362, PMID:7706766, PMID:8644733, PMID:8896428, PMID:9792863, PMID:11719352, PMID:12030801, PMID:17360334, PMID:19233912, PMID:19419417, PMID:19656450, PMID:23545314, PMID:24777812, PMID:25741868, PMID:28492532, PMID:2920211, PMID:661926, PMID:12426626 RGD:1599713, RGD:4145077, RGD:4144182 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
Porphyria Cutanea Tarda, Type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Urod uroporphyrinogen decarboxylase ISO ClinVar Annotator: match by term: Porphyria cutanea tarda, type I ClinVar PMID:8644733, PMID:25741868 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
variegate porphyria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: PPOX deficiency OMIM
ClinVar
PMID:8696333, PMID:8896550, PMID:8943161, PMID:9106528, PMID:9162021, PMID:9356458, PMID:9462220, PMID:11358905, PMID:11399207, PMID:11423500, PMID:11479183, PMID:11532995, PMID:11812557, PMID:11874997, PMID:11904676, PMID:12429850, PMID:12885340, PMID:14673107, PMID:15347835, PMID:15858186, PMID:16132052, PMID:17600748, PMID:18199861, PMID:18566337, PMID:19159930, PMID:19554541, PMID:20301613, PMID:24033266, PMID:24729993, PMID:25741868, PMID:26365338, PMID:28443246, PMID:28492532, PMID:28617828, PMID:30291871, PMID:30311386, PMID:31220083 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Ppox protoporphyrinogen oxidase ISO ClinVar Annotator: match by term: Variegate porphyria
ClinVar Annotator: match by term: Variegate porphyria, homozygous
ClinVar
OMIM
PMID:1946837, PMID:3319294, PMID:8290408, PMID:8673113, PMID:8817334, PMID:8852667, PMID:9738863, PMID:9811936, PMID:9829909, PMID:10401000, PMID:10486317, PMID:11173967, PMID:11286631, PMID:11298551, PMID:11348478, PMID:11929051, PMID:12380696, PMID:12655566, PMID:12922165, PMID:16433813, PMID:18570668, PMID:21048046, PMID:23409300, PMID:24033266, PMID:25741868, PMID:28492532, PMID:28653968 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16103
    Nutritional and Metabolic Diseases 4720
      disease of metabolism 4720
        porphyria 21
          Hepatic Porphyrias 18
            ALAD-Deficiency Porphyria 2
            acute intermittent porphyria + 4
            erythropoietic protoporphyria + 7
            hepatoerythropoietic porphyria 1
            hereditary coproporphyria + 1
            porphyria cutanea tarda + 7
            variegate porphyria 2
Path 2
Term Annotations click to browse term
  disease 16103
    Developmental Diseases 9506
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 8364
        genetic disease 7847
          inherited metabolic disorder 2223
            porphyria 21
              Hepatic Porphyrias 18
                ALAD-Deficiency Porphyria 2
                acute intermittent porphyria + 4
                erythropoietic protoporphyria + 7
                hepatoerythropoietic porphyria 1
                hereditary coproporphyria + 1
                porphyria cutanea tarda + 7
                variegate porphyria 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.