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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Cocaine-Related Disorders
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Accession:DOID:9005632 term browser browse the term
Definition:Disorders related or resulting from use of cocaine.
Synonyms:exact_synonym: cocaine addiction;   cocaine-related disorder
 primary_id: MESH:D019970
For additional species annotation, visit the Alliance of Genome Resources.


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Cocaine-Related Disorders term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase treatment IMP RGD PMID:22128851 RGD:9588542 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Ago2 argonaute RISC catalytic component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18311559 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr18:77,343,551...77,535,608
Ensembl chr18:77,343,551...77,535,593
JBrowse link
G Bche butyrylcholinesterase ISO CTD Direct Evidence: therapeutic CTD PMID:18292872, PMID:18514640, PMID:20060817, PMID:20971807, PMID:22935511, PMID:22960160, PMID:23000451, PMID:25814464 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bdnf brain-derived neurotrophic factor susceptibility ISO
IMP
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:14973246, PMID:17618281, PMID:17651427, PMID:18311559, PMID:19321768, PMID:20711185, PMID:20810894, PMID:23583595 RGD:38501054 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bdnfem1Sage brain-derived neurotrophic factor; ZFN induced mutant 1, Sage severity IMP RGD PMID:23583595 RGD:38501054
G Calm1 calmodulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:14725635 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV ISO CTD Direct Evidence: marker/mechanism CTD PMID:19001277 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:20886038 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9922984 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccser1 coiled-coil serine-rich protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 4:91,235,885...92,516,800
Ensembl chr 4:91,373,942...91,972,325
JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO RGD PMID:11268215 RGD:734739 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Ces1d carboxylesterase 1D ISO CTD Direct Evidence: therapeutic CTD PMID:12679808, PMID:12773168 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H ISO CTD Direct Evidence: therapeutic CTD PMID:19710369 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cfl1 cofilin 1 IEP protein:altered expression:striatum (rat) RGD PMID:27018876 RGD:11568696 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:13130510 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16314880, PMID:17596442, PMID:19052543 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18704099 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11717377, PMID:16359811, PMID:18596687 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone IEP
ISO
mRNA:decreased expression:hypothalamus (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:7796157, PMID:10516337, PMID:11797056, PMID:18596687, PMID:19349312, PMID:12782395 RGD:5508177 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crhbp corticotropin releasing hormone binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17437087 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IEP
ISO
mRNA:increased expression:anterior pituitary (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:19339610, PMID:12576179 RGD:5508175 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17437087 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Dnah8 dynein, axonemal, heavy chain 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr20:9,301,317...9,560,805
Ensembl chr20:9,313,271...9,560,682
JBrowse link
G Drd1 dopamine receptor D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15295029, PMID:16014726, PMID:16541082, PMID:20456009 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 IDA
ISO
protein:increased activity:caudate putamen (rat)
CTD Direct Evidence: marker/mechanism|therapeutic
CTD PMID:10900248, PMID:11751029, PMID:11923462, PMID:15010698, PMID:15042275, PMID:16541082, PMID:16971900, PMID:17332411, PMID:18418874, PMID:20494958, PMID:18284941 RGD:2311586 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:10523822, PMID:15100700, PMID:17332411, PMID:18566292, PMID:20494958 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Egr1 early growth response 1 treatment IEP
ISO
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16157275, PMID:16738229, PMID:18311559, PMID:25309368, PMID:21309948 RGD:10395309, RGD:10400880 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:20056891 NCBI chr20:4,576,033...4,592,980
Ensembl chr20:4,576,057...4,592,980
JBrowse link
G Esr2 estrogen receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17133264 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19014962 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17276011, PMID:18311559, PMID:19533625 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12657709, PMID:17898221, PMID:18539927, PMID:19331462 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19833324, PMID:20133874 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gad1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gcc1 GRIP and coiled-coil domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 4:55,708,040...55,719,884
Ensembl chr 4:55,709,096...55,713,620
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:14622243, PMID:15899247 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:17407494 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Gphn gephyrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
JBrowse link
G Gpsm1 G-protein signaling modulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15091342 NCBI chr 3:3,767,394...3,794,360
Ensembl chr 3:3,767,394...3,794,359
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:14684464, PMID:15764012, PMID:16495937, PMID:18430032, PMID:18486119 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18945913 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16014726, PMID:20149346 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:23727505 RGD:13792719 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:23727505 RGD:13792719 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO protein:decreased expression:prefrontal cortex (human) RGD PMID:23727505 RGD:13792719 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Grm2 glutamate metabotropic receptor 2 IMP knockout compared to wild type RGD PMID:28700935 RGD:38501064 NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046
JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20826661 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Hcrt hypocretin neuropeptide precursor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357203 NCBI chr10:88,669,216...88,670,430
Ensembl chr10:88,669,214...88,670,430
JBrowse link
G Hcrtr1 hypocretin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357203, PMID:19591850, PMID:19741128 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hdac4 histone deacetylase 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17988634 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Hdac5 histone deacetylase 5 ISO CTD Direct Evidence: therapeutic CTD PMID:17988634 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Homer1 homer scaffold protein 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16160706, PMID:16314758 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Homer2 homer scaffold protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15545022 NCBI chr 1:143,443,300...143,535,579
Ensembl chr 1:143,443,300...143,535,583
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11853856 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9603521, PMID:17509084 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Cocaine-Related Disorders
CTD
ClinVar
PMID:11259563, PMID:16300424, PMID:19212317 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B susceptibility ISO DNA:SNP:cds:rs1176744(human) RGD PMID:20838391 RGD:6480660 NCBI chr 8:53,247,881...53,278,170
Ensembl chr 8:53,248,705...53,277,859
JBrowse link
G Ice2 interactor of little elongation complex ELL subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 8:75,625,147...75,666,959
Ensembl chr 8:75,625,174...75,666,866
JBrowse link
G Ilk integrin-linked kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18702665, PMID:19629758 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: therapeutic CTD PMID:17898221 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Klhl5 kelch-like family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr14:44,805,213...44,867,075
Ensembl chr14:44,805,200...44,845,218
JBrowse link
G LOC100911804 apolipoprotein L3-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 7:118,979,230...118,986,699
Ensembl chr 7:118,979,608...118,983,984
JBrowse link
G Lrrc7 leucine rich repeat containing 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 2:264,910,594...265,300,860
Ensembl chr 2:264,910,594...265,300,868
JBrowse link
G Manea mannosidase, endo-alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686, PMID:19255376 NCBI chr 5:40,845,103...40,867,025
Ensembl chr 5:40,844,998...40,867,023
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16407894, PMID:20692647 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20692647 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mecp2 methyl CpG binding protein 2 treatment ISO
IMP
CTD Direct Evidence: marker/mechanism CTD PMID:20711185, PMID:20711185 RGD:12789445 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Mir130a microRNA 130a ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 3:72,141,037...72,141,124
Ensembl chr 3:72,141,037...72,141,124
JBrowse link
G Mir136 microRNA 136 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:133,716,761...133,716,842
Ensembl chr 6:133,716,761...133,716,842
JBrowse link
G Mir137 microRNA 137 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 2:221,658,106...221,658,207
Ensembl chr 2:221,658,106...221,658,207
JBrowse link
G Mir138-1 microRNA 138-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 8:131,731,726...131,731,824
Ensembl chr 8:131,731,726...131,731,824
JBrowse link
G Mir148b microRNA 148b ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 7:144,912,038...144,912,134
Ensembl chr 7:144,912,038...144,912,134
JBrowse link
G Mir154 microRNA 154 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:133,888,586...133,888,669
Ensembl chr 6:133,888,586...133,888,669
JBrowse link
G Mir186 microRNA 186 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 2:263,873,759...263,873,844
Ensembl chr 2:263,873,759...263,873,844
JBrowse link
G Mir212 microRNA 212 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20613834, PMID:20711185 NCBI chr10:62,014,702...62,014,812
Ensembl chr10:62,014,702...62,014,812
JBrowse link
G Mir301b microRNA 301b ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr11:88,129,426...88,129,503
Ensembl chr11:88,129,426...88,129,503
JBrowse link
G Mir324 microRNA 324 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr10:56,621,126...56,621,208
Ensembl chr10:56,621,124...56,621,212
JBrowse link
G Mir337 microRNA 337 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:133,705,920...133,706,016
Ensembl chr 6:133,705,920...133,706,016
JBrowse link
G Mir488 microRNA 488 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr13:76,198,593...76,198,671
Ensembl chr13:76,198,593...76,198,671
JBrowse link
G Mir500 microRNA 500 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr  X:16,121,332...16,121,411
Ensembl chr  X:16,121,322...16,121,413
JBrowse link
G Mir544 microRNA 544 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:133,879,169...133,879,246
Ensembl chr 6:133,879,169...133,879,246
JBrowse link
G Mir665 microRNA 665 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20643829 NCBI chr 6:133,706,457...133,706,550
Ensembl chr 6:133,706,457...133,706,550
JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17715210 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nps neuropeptide S ISO CTD Direct Evidence: marker/mechanism CTD PMID:19339610, PMID:20974945, PMID:21466221 NCBI chr 1:207,508,414...207,512,195
Ensembl chr 1:207,508,414...207,512,195
JBrowse link
G Npsr1 neuropeptide S receptor 1 treatment IMP RGD PMID:22982682 RGD:9831202 NCBI chr 8:25,246,174...25,483,582
Ensembl chr 8:25,246,292...25,482,647
JBrowse link
G Npy neuropeptide Y ISO CTD Direct Evidence: marker/mechanism CTD PMID:19063928 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 2:181,528,949...181,538,145
Ensembl chr 2:181,530,832...181,531,978
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12805318, PMID:19234455 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20826313, PMID:20947769 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18575850, PMID:20232055 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12815747, PMID:16893609, PMID:18762918 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16184603, PMID:17559549, PMID:18575850, PMID:18923396 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11750770, PMID:16520439, PMID:18201294, PMID:19279569 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prl prolactin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15064918 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prmt6 protein arginine methyltransferase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27506785 NCBI chr 2:213,173,403...213,180,721
Ensembl chr 2:213,173,403...213,178,632
Ensembl chr 2:213,173,403...213,178,632
JBrowse link
G Rhoa ras homolog family member A ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16339038 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Runx2 RUNX family transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12736327, PMID:16132061 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Slc1a2 solute carrier family 1 member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19625514 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:11320258, PMID:11746736, PMID:16537431, PMID:19602552 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 susceptibility ISO protein:decreased activity: :
CTD Direct Evidence: marker/mechanism
CTD PMID:11320258, PMID:20838391 RGD:6480660 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Smad1 SMAD family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27422367 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad5 SMAD family member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr17:8,307,448...8,336,996
Ensembl chr17:8,311,796...8,331,032
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27422367 NCBI chr 8:22,648,323...22,739,468
Ensembl chr 8:22,648,323...22,739,468
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30158054 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
G Snca synuclein alpha ISO mRNA,protein:increased expression:dopamine neuron
CTD Direct Evidence: marker/mechanism
CTD PMID:18055133, PMID:12684441 RGD:6480198 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sncg synuclein, gamma IMP RGD PMID:20579003 RGD:6218958 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707
JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27506785 NCBI chr10:85,460,059...85,517,671
Ensembl chr10:85,460,059...85,517,683
JBrowse link
G Syt13 synaptotagmin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 3:81,814,287...81,852,454
Ensembl chr 3:81,814,261...81,854,605
JBrowse link
G Tacr3 tachykinin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18422838 NCBI chr 2:240,021,152...240,118,971
Ensembl chr 2:240,021,152...240,118,971
JBrowse link
G Tenm3 teneurin transmembrane protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr16:46,422,676...46,929,023
Ensembl chr16:46,731,403...46,926,245
JBrowse link
G Tyk2 tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 8:22,118,224...22,149,807
Ensembl chr 8:22,124,560...22,150,005
JBrowse link
cocaine dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 IMP RGD PMID:29454035 RGD:13506950 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    Chemically-Induced Disorders 1196
      substance-related disorder 613
        Cocaine-Related Disorders 125
          cocaine abuse 0
          cocaine dependence 1
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      nervous system disease 10897
        central nervous system disease 9045
          brain disease 8370
            disease of mental health 6047
              substance-related disorder 613
                Cocaine-Related Disorders 125
                  cocaine abuse 0
                  cocaine dependence 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.