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ONTOLOGY REPORT - ANNOTATIONS


Term:Necrosis
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Accession:DOID:9005749 term browser browse the term
Definition:The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Synonyms:exact_synonym: Necroses
 primary_id: MESH:D009336;   RDO:0005338
For additional species annotation, visit the Alliance of Genome Resources.


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Necrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:2301913
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:11554173
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:11554173
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:11554173
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:2314239
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:11554173
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:11554173
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:11554173
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:11554173
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:11554173
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:11554173
G Bcr BCR, RhoGEF and GTPase activating protein JBrowse link 20 14,421,250 14,546,406 RGD:11554173
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:11554173
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:11554173
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:2314511
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:11554173
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:11554173
G Ctf1 cardiotrophin 1 JBrowse link 1 199,162,319 199,168,296 RGD:11554173
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:11554173
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:11554173
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:11554173
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:11554173
G Dpp7 dipeptidylpeptidase 7 JBrowse link 3 2,569,135 2,573,387 RGD:11554173
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:8655615
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:11554173
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11554173
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:11554173
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:11554173
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:8655615
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:11554173
G Gatm glycine amidinotransferase JBrowse link 3 114,711,570 114,728,155 RGD:11554173
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:11554173
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:11554173
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:11554173
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:11554173
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:11554173
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11554173
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:11554173
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11554173
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:11554173
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:11554173
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:11554173
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:11554173
G Mir192 microRNA 192 JBrowse link 1 221,634,971 221,635,080 RGD:11554173
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:11554173
G Mycn MYCN proto-oncogene, bHLH transcription factor JBrowse link 6 38,222,554 38,228,419 RGD:11554173
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11554173
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:11554173
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:11554173
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:11554173
G Puf60 poly-U binding splicing factor 60 JBrowse link 7 117,129,237 117,140,234 RGD:11554173
G Rbp4 retinol binding protein 4 JBrowse link 1 256,806,476 256,813,678 RGD:11554173
G Rdh13 retinol dehydrogenase 13 JBrowse link 1 72,956,017 72,983,811 RGD:11554173
G Set SET nuclear proto-oncogene JBrowse link 19 58,420,635 58,422,153 RGD:11554173
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:11554173
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:11554173
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Sod3 superoxide dismutase 3 JBrowse link 14 60,958,583 60,971,143 RGD:11554173
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:11554173
G Tbxa2r thromboxane A2 receptor JBrowse link 7 11,253,153 11,259,233 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:11554173
ARTHROGRYPOSIS, PERTHES DISEASE, AND UPWARD GAZE PALSY term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nek9 NIMA-related kinase 9 JBrowse link 6 109,121,524 109,162,433 RGD:8554872
RGD:11554173
RGD:7240710
Bisphosphonate-Associated Osteonecrosis of the Jaw term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:11041182
Femur Head Necrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:10046018
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:9479160
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:7240710
RGD:8554872
RGD:10046018
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6902907
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:6902907
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:10450838
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:10450838
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:11087286
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:12793062
G Mia MIA SH3 domain containing JBrowse link 1 83,991,577 83,993,270 RGD:10046018
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11541046
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:11554173
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:11060260
RGD:11062059
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:8554872
RGD:7240710
RGD:11554173
Infarction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:11554173
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:10395384
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:10395384
G Notch3 notch 3 JBrowse link 7 14,138,495 14,189,688 RGD:632418
G Polr2a RNA polymerase II subunit A JBrowse link 10 56,339,277 56,364,888 RGD:9681722
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:11554173
Legg-Calve-Perthes disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:7240710
RGD:8554872
G Gnptab N-acetylglucosamine-1-phosphate transferase subunits alpha and beta JBrowse link 7 28,956,363 29,023,232 RGD:8554872
osteonecrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:1578382
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:11554173
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:10449417

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  disease 14759
    Pathological Conditions, Signs and Symptoms 7254
      Pathologic Processes 4755
        Necrosis 84
          DNA Degradation, Necrotic 0
          Fat Necrosis + 0
          Gangrenes 0
          Infarction 6
          dental pulp necrosis 0
          osteonecrosis + 20
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