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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:hepatosplenic schistosomiasis
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Accession:DOID:9006550 term browser browse the term
Definition:Hepatosplenic schistosomiasis refers to the major complication of chronic infection with Schistosoma mansoni, S japonicum and S mekongi, schistosomal portal hypertension. It is usually associated with enlargement of the liver and spleen, and reversible hepatosplenomegaly may occur in early infections. It is a chronic complication, which develops as a consequence of inflammatory response.
Synonyms:exact_synonym: HSS
For additional species annotation, visit the Alliance of Genome Resources.


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hepatosplenic schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd209a CD209a antigen ISO mRNA,protein:decreased expression:spleen,liver (mouse) RGD PMID:29386115, PMID:24729611 RGD:39938990, RGD:39938995 NCBI chr12:2,341,960...2,347,543
Ensembl chr12:2,341,960...2,347,543
JBrowse link
G Clec4m C-type lectin domain family 4 member M ISO RGD PMID:18981244 RGD:39938988 NCBI chr12:2,817,633...2,826,303
Ensembl chr12:2,816,065...2,826,378
JBrowse link
G Krt18 keratin 18 disease_progression ISO protein:increased expression:serum (mouse, human) RGD PMID:21357724 RGD:21406434 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Serpinf1 serpin family F member 1 ISO RGD PMID:9038736 RGD:30296660 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease by infectious agent 1774
      parasitic infectious disease 240
        Parasitic Liver Diseases 21
          hepatosplenic schistosomiasis 4
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      gastrointestinal system disease 4632
        hepatobiliary disease 0
          liver disease 2413
            Parasitic Liver Diseases 21
              hepatosplenic schistosomiasis 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.