ONTOLOGY REPORT - ANNOTATIONS


Term:Metabolic Syndrome
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Accession:DOID:9006646 term browser browse the term
Definition:A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Synonyms:exact_synonym: Cardiovascular Syndromes, Metabolic;   Insulin Resistance Syndrome X;   Metabolic Cardiovascular Syndrome;   Metabolic Syndrome X;   Reaven syndrome X;   dysmetabolic syndrome X
 related_synonym: METABOLIC SYNDROME, SUSCEPTIBILITY TO
 primary_id: MESH:D024821
For additional species annotation, visit the Alliance of Genome Resources.


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Metabolic Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1601092
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:10047118
G Acat2 acetyl-CoA acetyltransferase 2 JBrowse link 1 47,972,399 47,992,654 RGD:1581921
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:2313234
RGD:11554173
RGD:5686800
RGD:5686428
RGD:5686407
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1601127
RGD:8554872
RGD:1331525
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1601134
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1601146
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring JBrowse link 9 94,228,960 94,232,001 RGD:14349049
G Aldoa aldolase, fructose-bisphosphate A JBrowse link 1 198,228,387 198,233,988 RGD:13673877
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:1601174
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1601183
RGD:5508220
G Apoa2 apolipoprotein A2 JBrowse link 13 89,596,872 89,598,805 RGD:2313955
G Apoa5 apolipoprotein A5 JBrowse link 8 50,559,079 50,561,720 RGD:2313315
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:1601198
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:2306766
RGD:1601223
G Apom apolipoprotein M JBrowse link 20 5,120,473 5,123,073 RGD:2314236
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1601248
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit JBrowse link 15 36,561,306 36,590,171 RGD:13838660
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:1601317
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:1580935
G Bglap bone gamma-carboxyglutamate protein JBrowse link 2 187,741,770 187,748,445 RGD:6483594
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:2314030
G Capn10 calpain 10 JBrowse link 9 100,104,000 100,112,833 RGD:1625050
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:1625798
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:11554173
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:4889977
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:2307208
RGD:619666
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:2314214
RGD:5490591
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:10400905
G Ciita class II, major histocompatibility complex, transactivator JBrowse link 10 5,212,621 5,260,641 RGD:5491201
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6482318
RGD:11554173
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:2314295
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:2317864
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:2307294
G Dgat1 diacylglycerol O-acyltransferase 1 JBrowse link 7 117,566,363 117,576,735 RGD:10401057
G Dio2 iodothyronine deiodinase 2 JBrowse link 6 114,475,156 114,489,443 RGD:2313696
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:5688391
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:2313865
G Fabp2 fatty acid binding protein 2 JBrowse link 2 227,080,912 227,083,654 RGD:1626401
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:1625406
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:11344884
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:11554173
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:10401890
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:2307350
RGD:10449117
G Gckr glucokinase regulator JBrowse link 6 26,355,296 26,385,761 RGD:7242423
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:1601300
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:1625021
RGD:8554872
RGD:7242555
RGD:2313748
G Hdac3 histone deacetylase 3 JBrowse link 18 31,073,057 31,094,347 RGD:9590183
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:1642702
G Hmga1 high mobility group AT-hook 1 JBrowse link 20 7,132,501 7,140,155 RGD:11554173
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:5508692
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10763276
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:1601642
G Hp haptoglobin JBrowse link 19 42,096,255 42,100,805 RGD:1626341
RGD:11041859
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:1625074
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:11554173
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:2313467
G Igf2 insulin-like growth factor 2 JBrowse link 1 215,828,102 215,839,081 RGD:2311520
G Igfbp2 insulin-like growth factor binding protein 2 JBrowse link 9 80,118,029 80,144,804 RGD:1626481
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:4889401
RGD:11554173
RGD:8655985
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11554173
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:1625430
G Inppl1 inositol polyphosphate phosphatase-like 1 JBrowse link 1 166,898,177 166,912,524 RGD:1626127
RGD:11554173
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:11554173
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6482864
G Itgav integrin subunit alpha V JBrowse link 3 71,113,269 71,205,958 RGD:1627640
G Kl Klotho JBrowse link 12 942,974 987,206 RGD:10403056
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:11554173
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:2311125
RGD:11554173
RGD:10053625
G Lipg lipase G, endothelial type JBrowse link 18 70,903,528 70,924,434 RGD:1580865
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:2306121
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:2298725
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:1581921
G Nampt nicotinamide phosphoribosyltransferase JBrowse link 6 52,122,085 52,156,473 RGD:1642337
RGD:1642345
G Neil1 nei-like DNA glycosylase 1 JBrowse link 8 61,817,258 61,824,023 RGD:11554173
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:1580935
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:11554173
RGD:8554872
RGD:13461762
RGD:13450928
G Nox1 NADPH oxidase 1 JBrowse link X 104,909,328 104,932,508 RGD:1580973
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:11554173
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:11554173
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6482748
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6482748
G Pla2g7 phospholipase A2 group VII JBrowse link 9 19,935,754 19,978,013 RGD:6482748
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:2311664
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:1642618
RGD:11554173
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:2301843
RGD:1580686
RGD:1580683
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:10059661
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:1642558
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:1642586
G Reg1a regenerating family member 1 alpha JBrowse link 4 109,497,962 109,500,626 RGD:10044029
G Retn resistin JBrowse link 12 2,201,909 2,203,649 RGD:7207155
RGD:11554173
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:2312292
G Serpina12 serpin family A member 12 JBrowse link 6 127,696,501 127,711,238 RGD:1547845
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11073736
G Shbg sex hormone binding globulin JBrowse link 10 56,219,861 56,237,354 RGD:2313785
RGD:11554173
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:9585758
RGD:11554173
RGD:10053569
G Slc27a1 solute carrier family 27 member 1 JBrowse link 16 19,997,823 20,016,193 RGD:1642790
G Soat2 sterol O-acyltransferase 2 JBrowse link 7 143,754,892 143,767,989 RGD:1581921
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:1601514
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2306739
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:1601641
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10450604
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:1624178
G Trib3 tribbles pseudokinase 3 JBrowse link 3 147,814,056 147,819,650 RGD:11554173
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:2313109
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:7483588
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:1625709
abdominal obesity-metabolic syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctf1 cardiotrophin 1 JBrowse link 1 199,162,319 199,168,296 RGD:13592920
G Gucy2c guanylate cyclase 2C JBrowse link 4 170,659,993 170,740,274 RGD:13592920
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:13592920
G Neil1 nei-like DNA glycosylase 1 JBrowse link 8 61,817,258 61,824,023 RGD:13592920
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:11554173
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:13592920
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:7241841
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:13592920
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:13592920
abdominal obesity-metabolic syndrome 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:13782087
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:13792503
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:13792503
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:13792503
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:13792561
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:13592920
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:13794382
G Mttp microsomal triglyceride transfer protein JBrowse link 2 243,366,181 243,407,608 RGD:8554872
RGD:7240710
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 JBrowse link 5 24,402,895 24,419,651 RGD:13592920
abdominal obesity-metabolic syndrome 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahdc1 AT hook, DNA binding motif, containing 1 JBrowse link 5 151,209,894 151,277,192 RGD:8554872
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B JBrowse link 1 85,112,819 85,120,840 RGD:7240710
RGD:8554872
Abdominal Obesity-Metabolic Syndrome 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lipe lipase E, hormone sensitive type JBrowse link 1 82,248,031 82,266,727 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14823
    syndrome 4218
      Metabolic Syndrome 325
        abdominal obesity-metabolic syndrome + 69
Path 2
Term Annotations click to browse term
  disease 14823
    Nutritional and Metabolic Diseases 4250
      disease of metabolism 4250
        acquired metabolic disease 2671
          carbohydrate metabolism disease 1738
            glucose metabolism disease 1738
              hyperinsulinism 549
                Insulin Resistance 510
                  Metabolic Syndrome 325
                    abdominal obesity-metabolic syndrome + 69
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.