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ONTOLOGY REPORT - ANNOTATIONS


Term:Experimental Autoimmune Neuritis
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Accession:DOID:9006647 term browser browse the term
Definition:An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Synonyms:exact_synonym: EAN (Experimental Allergic Neuritis);   EAN (Experimental Autoimmune Neuritis);   Experimental Allergic Neuritis;   Experimental Autoimmune Neuropathies;   Experimental Autoimmune Neuropathy
 primary_id: MESH:D009444
 alt_id: RDO:0006206
For additional species annotation, visit the Alliance of Genome Resources.


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Experimental Autoimmune Neuritis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adam8 ADAM metallopeptidase domain 8 JBrowse link 1 212,317,510 212,332,895 RGD:2325244
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:2313042
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:2306914
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:13782060
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:2289125
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:5688140
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:2312712
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:2307204
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:5491181
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:5491181
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:1600494
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:4891968
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:4891968
G Dcc DCC netrin 1 receptor JBrowse link 18 66,518,213 67,629,801 RGD:2314374
G Dhodh dihydroorotate dehydrogenase (quinone) JBrowse link 19 42,066,103 42,087,906 RGD:11040446
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:10395381
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10400894
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:9686114
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:10395381
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:5508466
G Il17a interleukin 17A JBrowse link 9 26,841,299 26,844,786 RGD:4888513
RGD:4831923
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7401218
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:11522768
G Mmp7 matrix metallopeptidase 7 JBrowse link 8 5,893,253 5,900,965 RGD:9685357
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:9685357
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:1580265
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:5688236
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5688236
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1642966
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:1581323
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:2312712
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:2312677
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:2312677
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7401218

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15590
    Animal Diseases 1582
      Animal Disease Models 1548
        Experimental Nervous System Autoimmune Disease 247
          Experimental Autoimmune Neuritis 43
Path 2
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      Immune & Inflammatory Diseases 3089
        immune system disease 2517
          hypersensitivity reaction disease 1489
            autoimmune hypersensitivity disease 1193
              autoimmune disease of the nervous system 404
                Experimental Nervous System Autoimmune Disease 247
                  Experimental Autoimmune Neuritis 43
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.