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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Viral Bronchiolitis
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Accession:DOID:9006928 term browser browse the term
Definition:An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.
Synonyms:exact_synonym: Viral Bronchiolitides
 primary_id: MESH:D001990
 alt_id: RDO:0005070
For additional species annotation, visit the Alliance of Genome Resources.


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Viral Bronchiolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 susceptibility ISO DNA:SNP: :rs2787094 c.2891G>C (human) RGD PMID:19258923 RGD:4142862 NCBI chr 3:123,595,018...123,607,549
Ensembl chr 3:123,595,560...123,607,352
JBrowse link
G C3 complement C3 resistance ISO RGD PMID:19258923, PMID:12235218 RGD:4142862, RGD:5129513 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Casp1 caspase 1 ISO RGD PMID:15196254 RGD:5130189 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cat catalase ISO protein:decreased expression:nasal mucus RGD PMID:21471094 RGD:5130770 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility ISO protein:increased secretion:serum (human)
DNA:snp:5' utr:g.-28C>G (human)
RGD PMID:19005677, PMID:19099677 RGD:4891884, RGD:4891881 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd14 CD14 molecule ISO DNA:polymorphism:promoter:c.-550C>T (human) RGD PMID:17471431 RGD:4144210 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd274 CD274 molecule treatment ISO mRNA:increased expression:lung RGD PMID:22797302, PMID:22797302 RGD:40818270, RGD:40818270 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:nasal mucus RGD PMID:20088864 RGD:4143440 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO DNA:SNP: :p.T280M (human) RGD PMID:18257903, PMID:16645504 RGD:4891891, RGD:4891905 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP
ISO
mRNA:increased expression:lung
protein:increased expression:plasma
RGD PMID:12909590, PMID:20561238 RGD:2311388, RGD:5135493 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:20561238 RGD:5135493 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Il17a interleukin 17A susceptibility ISO DNA:SNP: :rs7747909(human) RGD PMID:17703412 RGD:4889847 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility ISO DNA:SNP: :c.390T>C (rs315952) (human) RGD PMID:19258923 RGD:4142862 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4r interleukin 4 receptor susceptibility ISO associated with respiratory syncystial virus infection; DNA:polymorphism:cds:p. Q551R (human)
DNA:SNPs: :rs1805011,rs2057768 (human)
RGD PMID:12508140, PMID:20404812, PMID:17703412 RGD:4890022, RGD:4889996, RGD:4889847 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 ISO mRNA, protein:increased expression:respiratory system fluid/secretion RGD PMID:14738241 RGD:5128668 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il9 interleukin 9 ISO RGD PMID:15051283 RGD:5128692 NCBI chr17:8,558,827...8,561,950
Ensembl chr17:8,558,827...8,561,950
JBrowse link
G Klre1 killer cell lectin-like receptor, family E, member 1 susceptibility ISO DNA:SNP,haplotypes:3'utr:(rs10772271) (human) RGD PMID:29967528 RGD:39128159 NCBI chr 4:163,346,684...163,355,050
Ensembl chr 4:163,349,125...163,354,976
JBrowse link
G Klrk1 killer cell lectin like receptor K1 susceptibility ISO DNA:SNP,haplotypes:3'utr:(rs10772271) (human) RGD PMID:29967528 RGD:39128159 NCBI chr 4:163,392,652...163,403,735
Ensembl chr 4:163,393,217...163,403,653
JBrowse link
G Mpo myeloperoxidase ISO RGD PMID:7841728 RGD:5130995 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:19856476 RGD:5131164 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Nos2 nitric oxide synthase 2 susceptibility ISO DNA:SNP: :rs1060826(human) RGD PMID:17703412 RGD:4889847 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pdcd1 programmed cell death 1 ISO protein:increased expression:CD8 T cell RGD PMID:22797302 RGD:40818270 NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
JBrowse link
G Postn periostin ISO mRNA,protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Tlr4 toll-like receptor 4 ISO protein:increased expression:monocyte
protein:decreased expression:neutrophil
RGD PMID:14738455, PMID:19497921 RGD:4144819, RGD:4144183 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tlr5 toll-like receptor 5 susceptibility ISO DNA:snp:cds:p.F616L rs5744174 (human) RGD PMID:19258923 RGD:4142862 NCBI chr13:101,364,784...101,385,764
Ensembl chr13:101,381,510...101,385,764
JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:SNP: :rs1799724(human)
DNA:polymorphism:promoter: c. -308A>G (human)
protein:increased expression:nasal lavage fluid
RGD PMID:17703412, PMID:19849941, PMID:20088864 RGD:4889847, RGD:4143441, RGD:4143440 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tslp thymic stromal lymphopoietin severity ISO mRNA, protein:increased expression:nasal mucus (human) RGD PMID:28471975 RGD:38596342 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Vdr vitamin D receptor susceptibility ISO DNA:SNP (human)
DNA:SNP: :rs10735810 (human)
RGD PMID:18266602, PMID:17703412 RGD:4889843, RGD:4889847 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease by infectious agent 1774
      viral infectious disease 1466
        Viral Bronchiolitis 29
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      respiratory system disease 2748
        lower respiratory tract disease 1684
          lung disease 1643
            obstructive lung disease 430
              bronchitis 82
                bronchiolitis 67
                  Viral Bronchiolitis 29
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.