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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Viral Hemorrhagic Fevers
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Accession:DOID:9007401 term browser browse the term
Definition:A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Synonyms:exact_synonym: Viral Hemorrhagic Fever
 primary_id: MESH:D006482
 alt_id: RDO:0005324
For additional species annotation, visit the Alliance of Genome Resources.


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dengue disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd209 CD209 molecule severity ISO DNA:SNP:promoter: -336G>A (human)
ClinVar Annotator: match by term: Dengue fever, protection against
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:15564514, PMID:15838506, PMID:16379498, PMID:16274635 RGD:39939064 NCBI chr12:2,406,879...2,413,324
Ensembl chr12:2,406,879...2,413,324
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 treatment ISO RGD PMID:30098206 RGD:39938828 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa severity ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:26240159 RGD:13463456 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Gc GC, vitamin D binding protein ISO protein:increased expression:plasma RGD PMID:19845402 RGD:5509870 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:31821895 RGD:39939074 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment ISO RGD PMID:30098206 RGD:39938828 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il33 interleukin 33 severity ISO RGD PMID:30098206 RGD:39938828 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Kir3dl1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 susceptibility ISO DNA:deletion:cds RGD PMID:26385514 RGD:38676471 NCBI chr 1:73,306,564...73,345,009
Ensembl chr 1:73,307,569...73,344,955
JBrowse link
dengue hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec5a C-type lectin domain containing 5A ISO CTD Direct Evidence: therapeutic CTD PMID:18496526 NCBI chr 4:68,810,330...68,819,921
Ensembl chr 4:68,808,359...68,819,928
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa susceptibility ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:22817980 RGD:11040906 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Micb MHC class I polypeptide-related sequence B ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr 1:79,754,587...79,772,092
Ensembl chr 1:79,754,587...79,772,092
JBrowse link
G Plce1 phospholipase C, epsilon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Slc6a4 solute carrier family 6 member 4 severity ISO DNA;polymorphism:5'utr: (rs25531) (human) RGD PMID:30452889 RGD:38676265 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO DNA:SNPs: : RGD PMID:18071882 RGD:6482261 NCBI chr20:3,995,544...4,009,587
Ensembl chr20:3,995,544...4,009,587
JBrowse link
Ebola hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il3 interleukin 3 ISO protein: reduced expression: plasma RGD PMID:20957152 RGD:5686879 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
Hantavirus hemorrhagic fever with renal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin severity ISO RGD PMID:14555823 RGD:11035280 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoc3 apolipoprotein C3 disease_progression ISO RGD PMID:20797315 RGD:7207210 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Ifng interferon gamma severity ISO protein:increased expression:serum RGD PMID:22613426 RGD:6893374 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 severity ISO RGD PMID:25658420 RGD:40400702 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO protein:increased expression:T cell RGD PMID:21436245 RGD:5147436 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il33 interleukin 33 severity ISO RGD PMID:25658420 RGD:40400702 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Itgb3 integrin subunit beta 3 severity ISO protein:increased expression:platelet RGD PMID:18419255 RGD:6907404 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
Korean hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 IEP mRNA:increased expression:lung RGD PMID:17878294 RGD:2325989 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha treatment IMP RGD PMID:17878294 RGD:2325989 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
Lassa fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dag1 dystroglycan 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17287727 NCBI chr 8:116,980,501...116,993,182
Ensembl chr 8:116,980,497...116,993,193
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease by infectious agent 1774
      viral infectious disease 1466
        RNA Virus Infections 1301
          Viral Hemorrhagic Fevers 22
            Bolivian hemorrhagic fever 0
            Crimean-Congo hemorrhagic fever 0
            Ebola hemorrhagic fever 1
            Hantavirus hemorrhagic fever with renal syndrome + 8
            Kyasanur forest disease + 0
            Lassa fever 1
            Marburg hemorrhagic fever 0
            Omsk hemorrhagic fever 0
            Rift Valley fever 1
            dengue disease + 13
            yellow fever 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.