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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Otitis
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Accession:DOID:9007481 term browser browse the term
Definition:Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.
Synonyms:exact_synonym: Ear Inflammation;   Ear Inflammations;   Otitides
 primary_id: MESH:D010031;   RDO:0005953
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Acute Otitis Media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc4 actin related protein 2/3 complex, subunit 4 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984
JBrowse link
G Cald1 caldesmon 1 ISO mRNA, protein:decreased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO RGD PMID:10453785 RGD:11556224 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Dstn destrin, actin depolymerizing factor ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 3:138,024,508...138,051,304
Ensembl chr 3:138,024,508...138,051,298
JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:10453785 RGD:11556224 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Il17a interleukin 17A disease_progression IEP protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il22 interleukin 22 disease_progression IEP protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chr 7:61,236,037...61,240,502
Ensembl chr 7:61,236,037...61,240,502
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G S100a9 S100 calcium binding protein A9 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
labyrinthitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor ISO protein:increased expression: cochleas, endolymphatic sac: RGD PMID:12943369 RGD:7394706 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
mastoiditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein disease_progression ISO RGD PMID:22578647 RGD:9491592 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
otitis externa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein disease_progression ISO RGD PMID:22032882 RGD:9491591 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin treatment ISO RGD PMID:2459981, PMID:2473673 RGD:11553864, RGD:11553918 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 ISO ClinVar Annotator: match by term: Susceptibility to otitis media ClinVar PMID:30311386 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Bpifa1 BPI fold containing family A, member 1 ISS OMIM:166760 MouseDO NCBI chr 3:149,624,867...149,630,610
Ensembl chr 3:149,624,712...149,630,613
JBrowse link
G Btc betacellulin IEP mRNA:decreased expression:middle ear RGD PMID:12148846 RGD:2306978 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G C2 complement C2 ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G C3 complement C3 ISO associated with Pneumococcal Infections RGD PMID:21502587 RGD:7401269 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cat catalase treatment IEP protein:decreased activity:cochlea,serum: RGD PMID:22173336 RGD:7401215 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cby1 chibby family member 1, beta catenin antagonist ISS OMIM:166760 MouseDO NCBI chr 7:120,891,930...120,898,318
Ensembl chr 7:120,891,940...120,897,687
JBrowse link
G Cfb complement factor B ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Crp C-reactive protein treatment ISO RGD PMID:7724300 RGD:9491381 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ctsb cathepsin B IEP mRNA:increased expression:middle ear mucosa (rat) RGD PMID:15179208 RGD:1342442 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsk cathepsin K IEP mRNA:decreased expression:middle ear RGD PMID:15179208 RGD:1342442 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Ctsl cathepsin L IEP mRNA:decreased expression:middle ear mucosa (rat) RGD PMID:15179208 RGD:1342442 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 susceptibility ISO DNA:missense mutation:cds:p.T280M (human) RGD PMID:24718616 RGD:9491764 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO RGD PMID:20433028 RGD:11553910 NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203
JBrowse link
G Defb1 defensin beta 1 ISO RGD PMID:22072973 RGD:11554036 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
JBrowse link
G Dnah11 dynein, axonemal, heavy chain 11 ISO ClinVar Annotator: match by term: Susceptibility to otitis media ClinVar PMID:28492532, PMID:30311386 NCBI chr 6:145,784,893...146,099,212
Ensembl chr 6:145,785,275...146,099,053
JBrowse link
G Dnah5 dynein, axonemal, heavy chain 5 ISS OMIM:166760 MouseDO NCBI chr 2:80,947,730...81,143,997
NCBI chr 2:81,159,060...81,337,560
Ensembl chr 2:80,948,658...81,143,447
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment ISO RGD PMID:22610099 RGD:7771533 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G E2f4 E2F transcription factor 4 ISS OMIM:166760 MouseDO NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G Eda ectodysplasin-A ISO RGD PMID:31028034 RGD:14398763 NCBI chr  X:69,730,123...70,222,693
Ensembl chr  X:69,730,242...70,220,329
JBrowse link
G Edar ectodysplasin-A receptor treatment ISO RGD PMID:31028034 RGD:14398763 NCBI chr20:28,179,132...28,263,092
Ensembl chr20:28,179,140...28,263,037
JBrowse link
G Edaradd EDAR-associated death domain IAGP RGD PMID:31028034 RGD:14398763 NCBI chr17:90,802,280...90,843,476
Ensembl chr17:90,802,393...90,843,485
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISS OMIM:166760 MouseDO NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 ISS OMIM:166760 MouseDO NCBI chr 1:23,237,617...23,611,580
Ensembl chr 1:23,409,408...23,610,164
JBrowse link
G Fbxo11 F-box protein 11 ISS OMIM:166760 MouseDO NCBI chr 6:11,662,356...11,737,427
Ensembl chr 6:11,662,356...11,686,682
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISS OMIM:166760 MouseDO NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:20926702 RGD:8547580 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idua alpha-L-iduronidase ISS OMIM:166760 MouseDO NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762
JBrowse link
G Ifng interferon gamma ISO associated with adenoidal hypertrophy; protein:decreased expression:T cell:
associated with Pneumococcal infections;
RGD PMID:18266836, PMID:16730398 RGD:7987910, RGD:8142343 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 susceptibility ISO
IEP
associated with Pneumococcal Infections;protein:increased expression:middle ear, serum
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
DNA:SNP:promoter:-1082G>A (human)
associated with Haemophilus Infections
associated with respiratory syncytial virus infectious disease, associated with common cold;DNA:SNPs, haplotypes:promoter:-1082G>A, -819T>C, -592A>C (human)
RGD PMID:23404508, PMID:14500471, PMID:17908769, PMID:18524391, PMID:18560870, PMID:18771082 RGD:7364816, RGD:7365082, RGD:7365054, RGD:4891398, RGD:7365038, RGD:7365029 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il17a interleukin 17A severity ISO RGD PMID:24664502 RGD:8698659 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1a interleukin 1 alpha IEP associated with Haemophilus Infections;mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:22173336 RGD:7401215 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 disease_progression ISO RGD PMID:7769948 RGD:8662922 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 susceptibility ISO
IEP
DNA:polymorphism:promoter:-174G>C(human)
mRNA,protein:increased expression:middle ear,inner ear:
mRNA,protein:increased expression:middle ear:
RGD PMID:17908769, PMID:21271590, PMID:11165648 RGD:7365054, RGD:8547980, RGD:7829801 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lmna lamin A/C ISS OMIM:166760 MouseDO NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Lta4h leukotriene A4 hydrolase ISO RGD PMID:20433028 RGD:11553910 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ltb4r leukotriene B4 receptor ISO RGD PMID:20433028 RGD:11553910 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Ltc4s leukotriene C4 synthase ISO RGD PMID:20433028 RGD:11553910 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Mbl2 mannose binding lectin 2 ISO DNA:haplotype,SNP:promoter,exons: RGD PMID:16750996 RGD:8693692 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO
ISS
OMIM:166760 MouseDO PMID:26611891 RGD:11054805 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
JBrowse link
G Muc1 mucin 1, cell surface associated IEP associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 RGD:2303743 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Muc3 mucin 3, intestinal IEP associated with Pneumococcal Infections RGD PMID:11576628 RGD:2303743 NCBI chr12:22,535,663...22,584,775 JBrowse link
G Muc4 mucin 4, cell surface associated IEP
ISO
associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628, PMID:14690056 RGD:2303743, RGD:7349395 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming IEP
ISO
mRNA:increased expression:ear
associated with CHARGE Syndrome
RGD PMID:11425202, PMID:22539951 RGD:2324973, RGD:7349405 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
associated with CHARGE Syndrome
RGD PMID:14690056, PMID:22539951 RGD:7349395, RGD:7349405 NCBI chr 1:214,778,459...214,811,237
Ensembl chr 1:214,778,496...214,810,720
JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase ISS OMIM:166760 MouseDO NCBI chr10:88,979,363...88,986,879
Ensembl chr10:88,979,383...88,986,867
JBrowse link
G Nf2 neurofibromin 2 ISS OMIM:166760 MouseDO NCBI chr14:84,996,905...85,088,547
Ensembl chr14:84,996,905...85,088,523
JBrowse link
G Nisch nischarin ISS OMIM:166760 MouseDO NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561
JBrowse link
G Nos2 nitric oxide synthase 2 IEP associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked ISS OMIM:166760 MouseDO NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Plau plasminogen activator, urokinase treatment ISO RGD PMID:2473673 RGD:11553864 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plg plasminogen ISO ClinVar Annotator: match by term: Otitis media, susceptibility to ClinVar PMID:10233898, PMID:12850227, PMID:16849641, PMID:25741868, PMID:28492532, PMID:31064749 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Pth parathyroid hormone ISO protein:increased expression:serum (human) RGD PMID:23543299 RGD:7242409 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpl38 ribosomal protein L38 ISS OMIM:166760 MouseDO NCBI chr10:103,198,424...103,202,059
Ensembl chr 2:199,479,007...199,479,309
JBrowse link
G Sall4 spalt-like transcription factor 4 ISS OMIM:166760 MouseDO NCBI chr 3:165,520,155...165,538,176
Ensembl chr 3:165,520,392...165,537,940
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 IEP mRNA,protein:increased expression:epithelial cell RGD PMID:15799573 RGD:5144051 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 IEP RGD PMID:12206256 RGD:6484586 NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
JBrowse link
G Serpina1 serpin family A member 1 treatment ISO RGD PMID:2459981, PMID:2473673 RGD:11553864, RGD:11553918 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B ISS OMIM:166760 MouseDO NCBI chr10:17,209,152...17,296,449
Ensembl chr10:17,209,212...17,291,876
JBrowse link
G Tbx1 T-box transcription factor 1 ISS OMIM:166760 MouseDO NCBI chr11:86,552,022...86,561,647
Ensembl chr11:86,552,022...86,560,969
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 ISS OMIM:166760 MouseDO NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:increased expression:middle ear:
protein:increased expression:mucosa of middle ear,skin of ear canal:
associated with Pneumococcal Infections;
associated with Haemophilus Infections;
RGD PMID:23380629, PMID:24690988, PMID:19414550, PMID:19586996 RGD:7800666, RGD:8552995, RGD:8552783, RGD:7777086 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 ISO associated with Haemophilus Infections;
protein:increased expression:mucosa of middle ear,skin of ear canal:
protein:increased expression:middle ear:
RGD PMID:19586996, PMID:24690988, PMID:23380629 RGD:7777086, RGD:8552995, RGD:7800666 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor IEP
ISO
associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear
protein:increased expression:ear:
RGD PMID:18524391, PMID:22173336, PMID:21818352 RGD:4891398, RGD:7401215, RGD:7394703 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp73 tumor protein p73 ISS OMIM:166760 MouseDO NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Tpp2 tripeptidyl peptidase 2 ISO ClinVar Annotator: match by term: Susceptibility to otitis media ClinVar PMID:30311386 NCBI chr 9:50,664,048...50,744,803
NCBI chr 9:50,578,868...50,628,943
Ensembl chr 9:50,581,234...50,744,803
JBrowse link
G Tusc3 tumor suppressor candidate 3 ISO ClinVar Annotator: match by term: Susceptibility to otitis media ClinVar PMID:23806237, PMID:25741868, PMID:28492532, PMID:30311386 NCBI chr16:56,248,125...56,396,491
Ensembl chr16:56,247,659...56,396,502
JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA:increased expression:middle ear:
mRNA,protein:increased expression:middle ear,inner ear:
RGD PMID:22104377, PMID:21271590 RGD:8547975, RGD:8547980 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Otitis Media with Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:2454602 RGD:11560528 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G C3 complement C3 disease_progression ISO RGD PMID:11037838 RGD:7401253 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 IEP mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Glb1 galactosidase, beta 1 ISO RGD PMID:2837976 RGD:11557999 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gusb glucuronidase, beta ISO RGD PMID:2837976 RGD:11557999 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Ifng interferon gamma ISO protein:decreased expression:serum:
protein:decreased expression:middle ear:
RGD PMID:16055981, PMID:15938212 RGD:7987911, RGD:8142354 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:18568516 RGD:7394746 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 IEP protein:increased expression:middle ear RGD PMID:18975780 RGD:2317282 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor treatment ISO
IMP
RGD PMID:12297806, PMID:12297806 RGD:11530017, RGD:11530017 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Kdr kinase insert domain receptor IEP mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Ltf lactotransferrin treatment ISO RGD PMID:21079169 RGD:11554025 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:20713760, PMID:22336013 RGD:7364731, RGD:7364764 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:16540890, PMID:22336013 RGD:7364744, RGD:7364764 NCBI chr 1:214,778,459...214,811,237
Ensembl chr 1:214,778,496...214,810,720
JBrowse link
G Oxgr1 oxoglutarate receptor 1 ISO RGD PMID:23200873 RGD:7775025 NCBI chr15:105,399,596...105,422,559
Ensembl chr15:105,401,695...105,402,708
JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO RGD PMID:14759570 RGD:11554333 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Serpina1 serpin family A member 1 ISO RGD PMID:2454602 RGD:11560528 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:22336013 RGD:7364764 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:22336013 RGD:7364764 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:middle ear effusion: RGD PMID:18568516 RGD:7394746 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A IEP protein:increased expression:mucosa of middle ear: RGD PMID:22907120 RGD:8547964 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
suppurative otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:1696441 RGD:11556250 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Alb albumin ISO RGD PMID:1696441 RGD:11556250 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ifng interferon gamma disease_progression ISO RGD PMID:19640314 RGD:8142346 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    sensory system disease 5231
      auditory system disease 767
        Otitis 90
          labyrinthitis + 1
          otitis externa + 1
          otitis media + 90
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      nervous system disease 10897
        sensory system disease 5231
          Otorhinolaryngologic Diseases 1202
            auditory system disease 767
              Otitis 90
                labyrinthitis + 1
                otitis externa + 1
                otitis media + 90
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.