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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Parasitic Skin Diseases
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Accession:DOID:9007630 term browser browse the term
Definition:Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.
Synonyms:exact_synonym: Parasitic Skin Disease
 primary_id: MESH:D012876
 alt_id: RDO:0005443
For additional species annotation, visit the Alliance of Genome Resources.


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cutaneous leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase ISO protein:decreased activity:erythrocyte: RGD PMID:9892499 RGD:9479188 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO DNA:SNPs: :rs1061237, rs2586488 (human) RGD PMID:25562121 RGD:11041176 NCBI chrNW_004936490:11,448,552...11,465,836 JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20102417 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G Foxp3 forkhead box P3 ISO mRNA:increased expression:Peripheral blood mononuclear cell: RGD PMID:29205403 RGD:38455981 NCBI chrNW_004936721:1,118,376...1,125,282 JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:8154019, PMID:9234779, PMID:20102417 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:Peripheral blood mononuclear cell:
CTD
RGD
PMID:20102417, PMID:29205403 RGD:38455981 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:12739821, PMID:18924210 RGD:8549536, RGD:8549561 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il17a interleukin 17A ISO mRNA:increased expression:Peripheral blood mononuclear cell: RGD PMID:29205403 RGD:38455981 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20102417 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il23a interleukin 23 subunit alpha ISO RGD PMID:29078003 RGD:39457938 NCBI chrNW_004936646:743,630...745,998 JBrowse link
G Il4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20102417 NCBI chrNW_004936647:2,510,457...2,518,576 JBrowse link
G LOC101964209 C-C chemokine receptor type 1 ISO RGD PMID:12874303 RGD:5688168 NCBI chrNW_004936596:177,774...183,186 JBrowse link
G Lta lymphotoxin alpha no_association ISO DNA:SNP:intron:252A>G (human) RGD PMID:16950634 RGD:8548800 NCBI chrNW_004936727:1,940,081...1,941,022 JBrowse link
G Ltb lymphotoxin beta ISO RGD PMID:17911622 RGD:8548820 NCBI chrNW_004936727:1,929,533...1,932,339 JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:21091666 RGD:8657030 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO DNA:insertion/deletion (human) RGD PMID:20089160 RGD:5684930 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Sod1 superoxide dismutase 1 ISO protein:increased activity:erythrocyte: RGD PMID:9892499 RGD:9479188 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO RGD PMID:10458767 RGD:8661703 NCBI chrNW_004936506:7,091,982...7,185,938 JBrowse link
G Tlr2 toll like receptor 2 ISO protein:decreased expression:skin: RGD PMID:20493664 RGD:7794748 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 ISO protein:decreased expression:skin: RGD PMID:20493664 RGD:7794748 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tnf tumor necrosis factor no_association ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:promoter:-308G>A (rs1800629) (human)
CTD
RGD
PMID:16950634, PMID:20102417 RGD:8548800 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO protein:increased expression:brain RGD PMID:25014011 RGD:8695986 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G C3 complement C3 ISO RGD PMID:15378355 RGD:7401274 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17218153 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment ISO RGD PMID:21471446 RGD:7771536 NCBI chrNW_004936609:2,688,170...2,691,057 JBrowse link
G Dusp6 dual specificity phosphatase 6 treatment ISO RGD PMID:21471446 RGD:7771536 NCBI chrNW_004936507:6,309,114...6,314,512 JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:2145107, PMID:16540374, PMID:17218153 RGD:7829781 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16540374, PMID:20404924 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il18 interleukin 18 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:10768930, PMID:16879623 RGD:8655909 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il2 interleukin 2 ISO RGD PMID:6224858 RGD:8693326 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Il4 interleukin 4 treatment ISO protein:increased expression:serum RGD PMID:2145107, PMID:2521244 RGD:7829781, RGD:7829820 NCBI chrNW_004936647:2,510,457...2,518,576 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:26670606 NCBI chrNW_004936580:803,452...806,966 JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO lupoid leishmaniasis;protein:increased expression:skin of body (human) RGD PMID:23989888 RGD:36947873 NCBI chrNW_004936538:6,205,268...6,239,062 JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16540374 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfrsf18 TNF receptor superfamily member 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20139272 NCBI chrNW_004936737:1,905,307...1,910,356 JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10637281 NCBI chrNW_004936481:14,391,359...14,409,514 JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:17551101 RGD:8158083 NCBI chrNW_004936512:5,741,836...5,800,999 JBrowse link
mite infestation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29253318 NCBI chrNW_004936576:522,234...531,660 JBrowse link
mucocutaneous leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:7854095 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Lta lymphotoxin alpha ISO DNA:polymorphism:intron RGD PMID:7595196 RGD:8548799 NCBI chrNW_004936727:1,940,081...1,941,022 JBrowse link
G Tnf tumor necrosis factor ISO DNA:SNP:promoter:-308G>A (human) RGD PMID:7595196 RGD:8548799 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 severity ISO protein:increased expression:serum RGD PMID:22805723 RGD:8549600 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G LOC101958908 HLA class II histocompatibility antigen, DP alpha 1 chain ISO RGD PMID:8854084 RGD:6480649 NCBI chrNW_004936476:25,743,512...25,750,809 JBrowse link
Onchocerciasis, Ocular term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 ISO RGD PMID:19168746 RGD:8662882 NCBI chrNW_004936713:808,761...881,070 JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:11884755 RGD:7794682 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
scabies term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase treatment ISO RGD PMID:17884035 RGD:9479747 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
tick infestation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha ISO RGD PMID:7835923 RGD:7794724 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
Toxocara Canis Infection (Canine Roundworms) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 ISO protein:increased expression:plasma, respiratory system fluid/secretion RGD PMID:16168564 RGD:7248410 NCBI chrNW_004936538:835,436...848,907 JBrowse link
toxocariasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 treatment ISO RGD PMID:26732352 RGD:11534298 NCBI chrNW_004936647:2,510,457...2,518,576 JBrowse link
visceral leishmaniasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation induced cytidine deaminase ISO RGD PMID:31001826 RGD:32716386 NCBI chrNW_004936870:25,039...34,601 JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO protein:increased expression:blood, T cell RGD PMID:15379987 RGD:6893393 NCBI chrNW_004936596:223,660...224,739 JBrowse link
G Cd40 CD40 molecule treatment ISO RGD PMID:14573667 RGD:8547750 NCBI chrNW_004936514:6,936,915...6,947,246 JBrowse link
G Cd40lg CD40 ligand ISO RGD PMID:14573667 RGD:8547750 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:10467834 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Csf2 colony stimulating factor 2 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:8035028, PMID:17404324 RGD:10449527 NCBI chrNW_004936647:3,081,896...3,083,864 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO mRNA:increased expression:liver RGD PMID:16239557 RGD:27095947 NCBI chrNW_004936676:60,869...63,028 JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22461696 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22461696 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Ifng interferon gamma treatment ISO CTD Direct Evidence: therapeutic RGD
CTD
PMID:1901333, PMID:3104456, PMID:7854095 RGD:8158041 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:15716043, PMID:17404324, PMID:22461696, PMID:29745990 RGD:14975172 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il10ra interleukin 10 receptor subunit alpha ISO CTD Direct Evidence: therapeutic CTD PMID:15716043 NCBI chrNW_004936542:3,099,484...3,113,159 JBrowse link
G Il18 interleukin 18 susceptibility ISO RGD PMID:16879623 RGD:8655922 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17404324 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Lta lymphotoxin alpha severity ISO DNA:polymorphisms RGD PMID:12438370, PMID:15579454 RGD:8548784, RGD:8548789 NCBI chrNW_004936727:1,940,081...1,941,022 JBrowse link
G Ltb lymphotoxin beta ISO RGD PMID:12115620 RGD:8548822 NCBI chrNW_004936727:1,929,533...1,932,339 JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:16597321, PMID:17067929 RGD:5684944 NCBI chrNW_004936569:888,309...895,991 JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO RGD PMID:24242758 RGD:8661696 NCBI chrNW_004936506:7,091,982...7,185,938 JBrowse link
G Tlr2 toll like receptor 2 disease_progression ISO RGD PMID:23589575 RGD:15090808 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tnf tumor necrosis factor severity ISO DNA:polymorphisms
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:1901333, PMID:12438370, PMID:15579454, PMID:22461696 RGD:8548784, RGD:8548789 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11962
    disease by infectious agent 1571
      parasitic infectious disease 188
        Parasitic Skin Diseases 45
          Larva Migrans + 2
          cysticercosis + 0
          dioctophymiasis 0
          leishmaniasis + 41
          lice infestation + 0
          onchocerciasis + 4
          parasitic ectoparasitic infectious disease + 3
          scabies + 1
Path 2
Term Annotations click to browse term
  disease 11962
    disease of anatomical entity 11526
      nervous system disease 9457
        sensory system disease 4631
          skin disease 2424
            Infectious Skin Diseases 143
              Parasitic Skin Diseases 45
                Larva Migrans + 2
                cysticercosis + 0
                dioctophymiasis 0
                leishmaniasis + 41
                lice infestation + 0
                onchocerciasis + 4
                parasitic ectoparasitic infectious disease + 3
                scabies + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.