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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Retinal Neovascularization
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Accession:DOID:9007748 term browser browse the term
Definition:Formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina.
Synonyms:primary_id: MESH:D015861;   RDO:0006930
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
Retinal Neovascularization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col4a1 collagen type IV alpha 1 chain ISO ClinVar Annotator: match by term: Retinal neovascularization ClinVar PMID:30311386 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cth cystathionine gamma-lyase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27273718 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Epha2 Eph receptor A2 IDA RGD PMID:16359662 RGD:1580975 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Hgf hepatocyte growth factor ISO mRNA:increased expression:retina: RGD PMID:17389513 RGD:8548541 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment ISO RGD PMID:21414312 RGD:8695956 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Il18 interleukin 18 ISO mRNA, protein:increased expression:retina RGD PMID:17562991, PMID:17234681 RGD:8655891, RGD:8655930 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Itgav integrin subunit alpha V ISO RGD PMID:12063036 RGD:1582452 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Jam3 junctional adhesion molecule 3 ISO RGD PMID:15994945 RGD:7488936 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
JBrowse link
G Lrp1 LDL receptor related protein 1 IEP protein:increased expression:retina, muller cell RGD PMID:16979164 RGD:1625022 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO associated with Oxygen-Induced Retinopathy RGD PMID:25366488 RGD:10003164 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ndp norrin cystine knot growth factor NDP ISO CTD Direct Evidence: marker/mechanism CTD PMID:29654250 NCBI chr  X:6,791,090...6,815,586
Ensembl chr  X:6,791,136...6,815,583
Ensembl chr  X:6,791,136...6,815,583
JBrowse link
G Nf1 neurofibromin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29847659 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Prpf8 pre-mRNA processing factor 8 ISO ClinVar Annotator: match by term: Retinal neovascularization ClinVar PMID:30311386 NCBI chr10:63,635,239...63,658,360
Ensembl chr10:63,635,219...63,658,361
JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO associated with Oxygen-Induced Retinopathy; human protein in a mouse model RGD PMID:11867604 RGD:8554881 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Sod1 superoxide dismutase 1 ISO RGD PMID:19142872 RGD:8655607 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Vegfa vascular endothelial growth factor A IDA
associated with hypoxia;mRNA,protein:increased expression:retina:
associated with hypoxia;mRNA:increased expression:retina:
RGD PMID:12900522, PMID:23324288, PMID:7846076, PMID:8859080 RGD:1580564, RGD:8548102, RGD:8547994, RGD:7483620 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B ISO RGD PMID:19369214 RGD:2314323 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16045
    sensory system disease 5213
      eye disease 2652
        retinal disease 780
          Retinal Neovascularization 17
Path 2
Term Annotations click to browse term
  disease 16045
    Pathological Conditions, Signs and Symptoms 8735
      Pathologic Processes 6121
        Metaplasia 84
          Neovascularization, Pathologic 72
            Ocular Neovascularization 64
              Retinal Neovascularization 17
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.