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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Mononegavirales Infections
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Accession:DOID:9007829 term browser browse the term
Definition:Infections with viruses of the order MONONEGAVIRALES. The concept includes FILOVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; and RHABDOVIRIDAE INFECTIONS.
Synonyms:exact_synonym: Mononegavirales Infection
 primary_id: MESH:D018701;   RDO:0005036
For additional species annotation, visit the Alliance of Genome Resources.


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borna disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldoc aldolase, fructose-bisphosphate C ISO mRNA, protein:decreased expression:cerebellum, Purkinje cell RGD PMID:17182680 RGD:2301132 NCBI chrNW_004955481:4,576,913...4,580,999
Ensembl chrNW_004955481:4,576,913...4,580,999
JBrowse link
G Atf4 activating transcription factor 4 ISO protein:increased expression:cerebellum RGD PMID:16912310 RGD:32733622 NCBI chrNW_004955413:25,406,589...25,408,727
Ensembl chrNW_004955413:25,406,589...25,412,218
JBrowse link
G Atf6 activating transcription factor 6 ISO protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004955462:14,352,956...14,553,299
Ensembl chrNW_004955462:14,357,945...14,548,543
JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO RGD PMID:16612977 RGD:2289373 NCBI chrNW_004955422:11,106,061...11,189,951 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:12053272 RGD:4891998 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO mRNA:increased expression:brain RGD PMID:12053272 RGD:4891998 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO mRNA,protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO protein:increased expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004955448:1,743,060...1,781,401
Ensembl chrNW_004955448:1,743,060...1,781,466
JBrowse link
G Gja1 gap junction protein alpha 1 ISO RGD PMID:18538309 RGD:7364785 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095
JBrowse link
G Gjb6 gap junction protein beta 6 ISO RGD PMID:18538309 RGD:7364785 NCBI chrNW_004955497:1,018,610...1,027,593
Ensembl chrNW_004955497:1,018,610...1,027,360
JBrowse link
G Il16 interleukin 16 ISO protein:increased expression:brain RGD PMID:14698845 RGD:1354526 NCBI chrNW_004955416:11,876,317...11,987,548 JBrowse link
G Mif macrophage migration inhibitory factor ISO protein:increased expression:astrocyte RGD PMID:11870869 RGD:1642006 NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
JBrowse link
G Parg poly(ADP-ribose) glycohydrolase ISO mRNA:decreased expression:hippocampus RGD PMID:18057239 RGD:2316738 NCBI chrNW_004955556:435,264...539,935
Ensembl chrNW_004955556:435,027...535,941
JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO mRNA,protein:increased expression,increased activity:neuron, glial cell: RGD PMID:18057239 RGD:2316738 NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615
JBrowse link
G S100b S100 calcium binding protein B ISO protein:decreased expression:cerebellum, cerebral cortex RGD PMID:17376896 RGD:5508841 NCBI chrNW_004955407:42,972,584...42,980,510
Ensembl chrNW_004955407:42,972,584...42,980,510
JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO protein:increased expression:brain (rat) RGD PMID:12106671 RGD:38549588 NCBI chrNW_004955481:3,088,440...3,122,421
Ensembl chrNW_004955481:3,088,416...3,125,711
JBrowse link
G Xbp1 X-box binding protein 1 ISO mRNA,protein:altered expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link
measles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2-microglobulin ISO protein:increased expression:plasma RGD PMID:1402029 RGD:6482707 NCBI chrNW_004955416:11,205,503...11,211,325
Ensembl chrNW_004955416:11,204,849...11,215,568
JBrowse link
G Cd46 CD46 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:8402913 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chrNW_004955545:1,657,728...1,662,112 JBrowse link
Nasu-Hakola disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy ClinVar PMID:12080485, PMID:12754369, PMID:12925681, PMID:15883308, PMID:18546367, PMID:21834902, PMID:23399524, PMID:25615530, PMID:25741868, PMID:27995897, PMID:28492532, PMID:28768830, PMID:29142083 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697
JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP ISO OMIM NCBI chrNW_004955468:2,673,657...2,677,633
Ensembl chrNW_004955468:2,673,980...2,677,321
JBrowse link
Paramyxoviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:nasal mucus (human) RGD PMID:20182399 RGD:4891406 NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20053825 RGD:4891886 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:nasal mucus RGD PMID:20182399 RGD:4891406 NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
JBrowse link
Pneumovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il21r interleukin 21 receptor ISO RGD PMID:22238461 RGD:6892925 NCBI chrNW_004955493:5,613,704...5,646,692
Ensembl chrNW_004955493:5,613,564...5,650,583
JBrowse link
rabies term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2n1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO RGD PMID:17010311 RGD:18337278 NCBI chrNW_004955452:1,044,696...1,046,657
Ensembl chrNW_004955452:1,043,459...1,046,669
JBrowse link
G Nefh neurofilament heavy ISO protein:increased expression:spinal cord: RGD PMID:29509660 RGD:27226884 NCBI chrNW_004955455:3,735,330...3,744,714
Ensembl chrNW_004955455:3,735,410...3,744,107
JBrowse link
respiratory syncytial virus infectious disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 treatment
severity
ISO human protein in a mouse model RGD PMID:26813885 RGD:32716392 NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:lung RGD PMID:11134301 RGD:4891417 NCBI chrNW_004955481:9,085,943...9,089,147 JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO mRNA:increased expression:lung RGD PMID:17641031 RGD:4145495 NCBI chrNW_004955433:15,052,616...15,054,732
Ensembl chrNW_004955433:15,053,061...15,054,572
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:altered expression:lung, T cell (mouse) RGD PMID:19124761 RGD:4891880 NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
JBrowse link
G Cd274 CD274 molecule severity ISO protein:increased expression: lung RGD PMID:25465101 RGD:11056952 NCBI chrNW_004955434:9,487,309...9,508,366
Ensembl chrNW_004955434:9,487,315...9,505,904
JBrowse link
G Cd28 CD28 molecule ISO RGD PMID:18056387 RGD:5131621 NCBI chrNW_004955457:11,159,769...11,253,099
Ensembl chrNW_004955457:11,162,282...11,192,991
JBrowse link
G Cftr CF transmembrane conductance regulator ISO DNA:mutation: : RGD PMID:20015999 RGD:4140389 NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:12941892, PMID:16424189 RGD:4892016, RGD:4892018 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:18624292 RGD:5135483 NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:15916706 RGD:5135444 NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18624292 RGD:5135483 NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
JBrowse link
G Dnase1 deoxyribonuclease 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28780505 NCBI chrNW_004955442:13,733,107...13,736,527 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:17425601, PMID:20209309 RGD:4140425 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
JBrowse link
G Ifng interferon gamma ISO associated with Otitis media;protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:19352211, PMID:21937650 RGD:8142352 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G Il10 interleukin 10 severity ISO RGD PMID:20209309 RGD:4140425 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Il13 interleukin 13 ISO RGD PMID:18250447 RGD:4145641 NCBI chrNW_004955408:4,046,406...4,049,795 JBrowse link
G Il17a interleukin 17A severity ISO protein:increased expression:plasma RGD PMID:19738511 RGD:4889103 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
JBrowse link
G Il18 interleukin 18 ISO DNA:polymorphism:intron:rs360721 (human) RGD PMID:18043444, PMID:20130064 RGD:4889550, RGD:4889584 NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
JBrowse link
G Il1rl1 interleukin 1 receptor like 1 ISO RGD PMID:11283151 RGD:5144238 NCBI chrNW_004955470:7,779,828...7,849,157 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO RGD PMID:20639494 RGD:5147443 NCBI chrNW_004955421:22,642,004...22,694,729
Ensembl chrNW_004955421:22,641,511...22,694,913
JBrowse link
G Il33 interleukin 33 ISO RGD PMID:26044350, PMID:28771101 RGD:11342984, RGD:39939029 NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
JBrowse link
G Il5 interleukin 5 severity ISO RGD PMID:25410867 RGD:11354937 NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha ISO protein:decreased expression:blood, eosinophil RGD PMID:16734609 RGD:5128618 NCBI chrNW_004955421:10,211,594...10,259,760
Ensembl chrNW_004955421:10,221,694...10,259,885
JBrowse link
G Il6 interleukin 6 severity ISO associated with Otitis media;protein:increased expression:serum:
protein:increased expression:nasal mucus
RGD PMID:19352211, PMID:20622030 RGD:4143259, RGD:8142352 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Il9 interleukin 9 susceptibility ISO DNA:SNPs: :rs2069885, rs1799962 (human) RGD PMID:19915054, PMID:20503287 RGD:5128684, RGD:5128685 NCBI chrNW_004955408:30,950,816...30,953,571
Ensembl chrNW_004955408:30,950,816...30,953,571
JBrowse link
G Irf1 interferon regulatory factor 1 ISO protein:increased expression:dorsal root ganglion RGD PMID:20045913 RGD:5128775 NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO associated with Respiratory Hypersensitivity; protein:increased expression:lung RGD PMID:15130904 RGD:5131205 NCBI chrNW_004955476:11,061,405...11,084,294 JBrowse link
G Ngf nerve growth factor ISO RGD PMID:19824047 RGD:4891065 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059
JBrowse link
G Ngfr nerve growth factor receptor ISO RGD PMID:19824047 RGD:4891065 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305
JBrowse link
G Pdcd1 programmed cell death 1 ISO protein:increased expression:CD4 Tcell, CD8 Tcell from lung:
protein:increased expression: CD8 Tcell from nasal wash:
RGD PMID:25465101 RGD:11056952 NCBI chrNW_004955542:49,290...57,747
Ensembl chrNW_004955542:49,259...58,823
JBrowse link
G Pde12 phosphodiesterase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055709 NCBI chrNW_004955430:7,272,911...7,277,726
Ensembl chrNW_004955430:7,272,765...7,277,726
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 treatment ISS
IEP
RGD PMID:23018837, PMID:23018837 RGD:11554170, RGD:11554170 NCBI chrNW_004955487:1,988,226...2,001,731
Ensembl chrNW_004955487:1,987,405...2,001,731
JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chrNW_004955481:4,743,458...4,763,766
Ensembl chrNW_004955481:4,743,458...4,763,766
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO RGD PMID:12847279 RGD:5144208 NCBI chrNW_004955599:688,414...690,644 JBrowse link
G Sftpb surfactant protein B severity ISO protein:decreased expression:lung
DNA:SNPs:promoter, cds, intron:-32G>T (rs2077079), p.T131I (rs1130866), 5781A>C (rs2040349) (human)
RGD PMID:10194154, PMID:17498296 RGD:4143382, RGD:4143439 NCBI chrNW_004955424:1,849,313...1,858,087
Ensembl chrNW_004955424:1,849,314...1,858,087
JBrowse link
G Sftpc surfactant protein C ISO DNA:polymorphism: :138A>C, 186A>G (human) RGD PMID:17121584, PMID:19304906 RGD:4144065, RGD:4144116 NCBI chrNW_004955403:45,649,149...45,651,421
Ensembl chrNW_004955403:45,649,122...45,651,837
JBrowse link
G Sftpd surfactant protein D susceptibility ISO protein:decreased expression:lung
DNA:polymorphisms: :p.M11T, p.A160T (human
RGD PMID:10194154, PMID:19287351 RGD:4143439, RGD:4143495 NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
JBrowse link
G Tac1 tachykinin precursor 1 ISO mRNA,protein:increased expression:lung RGD PMID:10516226 RGD:5147822 NCBI chrNW_004955432:13,991,647...13,999,665
Ensembl chrNW_004955432:13,991,414...13,999,728
JBrowse link
G Tacr1 tachykinin receptor 1 treatment ISO RGD PMID:10516226 RGD:5147822 NCBI chrNW_004955424:10,614,340...10,761,872
Ensembl chrNW_004955424:10,614,340...10,761,872
JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chrNW_004955495:4,197,083...4,204,999
Ensembl chrNW_004955495:4,202,372...4,204,513
JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:19019963 RGD:4889534 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr3 toll like receptor 3 ISO RGD PMID:16424225 RGD:5129224 NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
JBrowse link
G Tlr4 toll like receptor 4 susceptibility
no_association
ISO DNA:polymorphisms:cds:p.D259G, T359I (human)
DNA:SNP:cds:p.D299G (human)
DNA:SNPs:cds:p.D299G, T399I (human)
RGD PMID:17264400, PMID:17449325, PMID:17709532, PMID:19019963 RGD:4144161, RGD:4144164, RGD:4144167, RGD:4889534 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tlr6 toll like receptor 6 ISO RGD PMID:19019963 RGD:4889534 NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942
JBrowse link
G Tlr7 toll like receptor 7 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chrNW_004955544:424,897...443,562
Ensembl chrNW_004955544:424,850...443,564
JBrowse link
G Tlr8 toll like receptor 8 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chrNW_004955544:302,027...317,110
Ensembl chrNW_004955544:303,319...306,426
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:Bronchoalveolar lavage fluid RGD PMID:15791294 RGD:4145715 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
G Tslp thymic stromal lymphopoietin sexual_dimorphism ISO mRNA:increased expression:lung (mouse)
protein:increased expression:nasal mucus (human)
RGD PMID:27156176, PMID:28471975, PMID:31076663 RGD:38549376, RGD:38596342, RGD:38596346 NCBI chrNW_004955418:4,041,529...4,045,534 JBrowse link
Respirovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl28 C-C motif chemokine ligand 28 ISO mRNA:increased expression:lung (mouse) RGD PMID:17954569 RGD:4892194 NCBI chrNW_004955446:18,902,465...18,925,178
Ensembl chrNW_004955446:18,902,636...18,925,561
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:lung RGD PMID:16816895 RGD:5130923 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
JBrowse link
Vesicular Stomatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:26418342 NCBI chrNW_004955437:396,736...411,144
Ensembl chrNW_004955437:396,742...411,144
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11834
    disease by infectious agent 1549
      viral infectious disease 1291
        RNA Virus Infections 1162
          Mononegavirales Infections 76
            Filoviridae Infections + 0
            Paramyxoviridae Infections + 58
            Rhabdoviridae Infections + 3
            borna disease 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.