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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Mononegavirales Infections
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Accession:DOID:9007829 term browser browse the term
Definition:Infections with viruses of the order MONONEGAVIRALES. The concept includes FILOVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; and RHABDOVIRIDAE INFECTIONS.
Synonyms:exact_synonym: Mononegavirales Infection
 primary_id: MESH:D018701;   RDO:0005036
For additional species annotation, visit the Alliance of Genome Resources.


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borna disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDOC aldolase, fructose-bisphosphate C ISO mRNA, protein:decreased expression:cerebellum, Purkinje cell RGD PMID:17182680 RGD:2301132 NCBI chr 9:42,778,637...42,782,950
Ensembl chr 9:42,778,637...42,782,479
JBrowse link
G ATF4 activating transcription factor 4 ISO protein:increased expression:cerebellum RGD PMID:16912310 RGD:32733622 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993
JBrowse link
G ATF6 activating transcription factor 6 ISO protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr38:20,705,167...20,903,852
Ensembl chr38:20,709,038...20,903,814
JBrowse link
G CD44 CD44 molecule ISO RGD PMID:16612977 RGD:2289373 NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:12053272 RGD:4891998 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO mRNA:increased expression:brain RGD PMID:12053272 RGD:4891998 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808
JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO mRNA,protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A ISO protein:increased expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr23:45,202,663...45,235,559
Ensembl chr23:45,202,022...45,235,559
JBrowse link
G GJA1 gap junction protein alpha 1 ISO RGD PMID:18538309 RGD:7364785 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936
JBrowse link
G GJB6 gap junction protein beta 6 ISO RGD PMID:18538309 RGD:7364785 NCBI chr25:17,912,036...17,922,310
Ensembl chr25:17,911,262...17,921,605
JBrowse link
G IL16 interleukin 16 ISO protein:increased expression:brain RGD PMID:14698845 RGD:1354526 NCBI chr 3:56,473,485...56,575,504
Ensembl chr 3:56,473,486...56,575,104
JBrowse link
G PARG poly(ADP-ribose) glycohydrolase ISO mRNA:decreased expression:hippocampus RGD PMID:18057239 RGD:2316738 NCBI chr28:1,651,698...1,767,210
Ensembl chr28:1,652,670...1,766,895
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO mRNA,protein:increased expression,increased activity:neuron, glial cell: RGD PMID:18057239 RGD:2316738 NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127
JBrowse link
G S100B S100 calcium binding protein B ISO protein:decreased expression:cerebellum, cerebral cortex RGD PMID:17376896 RGD:5508841 NCBI chr31:39,783,990...39,788,289
Ensembl chr31:39,784,506...39,788,183
JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO protein:increased expression:brain (rat) RGD PMID:12106671 RGD:38549588 NCBI chr 9:44,224,026...44,259,655
Ensembl chr 9:44,224,229...44,259,736
JBrowse link
G XBP1 X-box binding protein 1 ISO mRNA,protein:altered expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chr26:22,162,675...22,168,149 JBrowse link
Ebola hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL3 interleukin 3 ISO protein: reduced expression: plasma RGD PMID:20957152 RGD:5686879 NCBI chr11:20,330,480...20,332,668
Ensembl chr11:20,330,480...20,332,668
JBrowse link
measles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin ISO protein:increased expression:plasma RGD PMID:1402029 RGD:6482707 NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997
JBrowse link
G LOC609365 CD46 molecule, complement regulatory protein-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:8402913 NCBI chr 7:6,602,762...6,646,561 JBrowse link
G MUC1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690
JBrowse link
Nasu-Hakola disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy ClinVar PMID:12080485, PMID:12754369, PMID:12925681, PMID:15883308, PMID:18546367, PMID:21834902, PMID:23399524, PMID:25615530, PMID:25741868, PMID:27995897, PMID:28492532, PMID:28768830, PMID:29142083 NCBI chr12:9,915,692...9,928,322
Ensembl chr12:9,915,677...9,928,174
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP ISO OMIM NCBI chr 1:116,757,271...116,760,453
Ensembl chr 1:116,757,289...116,772,325
JBrowse link
Paramyxoviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:nasal mucus (human) RGD PMID:20182399 RGD:4891406 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20053825 RGD:4891886 NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095
JBrowse link
Pneumovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL21R interleukin 21 receptor ISO RGD PMID:22238461 RGD:6892925 NCBI chr 6:19,181,846...19,217,915
Ensembl chr 6:19,182,071...19,217,931
JBrowse link
rabies term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEFH neurofilament heavy ISO protein:increased expression:spinal cord: RGD PMID:29509660 RGD:27226884 NCBI chr26:22,726,523...22,735,129
Ensembl chr26:22,726,526...22,735,125
JBrowse link
respiratory syncytial virus infectious disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin I converting enzyme 2 severity
treatment
ISO human protein in a mouse model RGD PMID:26813885 RGD:32716392 NCBI chr  X:11,798,839...11,839,591
Ensembl chr  X:11,798,839...11,900,594
JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:lung RGD PMID:11134301 RGD:4891417 NCBI chr 9:38,931,895...38,936,969
Ensembl chr 9:38,933,514...38,961,187
JBrowse link
G CCL17 C-C motif chemokine ligand 17 ISO mRNA:increased expression:lung RGD PMID:17641031 RGD:4145495 NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:altered expression:lung, T cell (mouse) RGD PMID:19124761 RGD:4891880 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO DNA:snps:5' utr:g.-2459A>G, g.-2554G>T (human)
protein:increased expression:blood, monocyte (human)
RGD PMID:12964123, PMID:18439876 RGD:4892079, RGD:4892113 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952
JBrowse link
G CD274 CD274 molecule severity ISO protein:increased expression: lung RGD PMID:25465101 RGD:11056952 NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522
JBrowse link
G CD28 CD28 molecule ISO RGD PMID:18056387 RGD:5131621 NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854
JBrowse link
G CFTR CF transmembrane conductance regulator ISO DNA:mutation: : RGD PMID:20015999 RGD:4140389 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:12941892, PMID:16424189 RGD:4892016, RGD:4892018 NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:18624292 RGD:5135483 NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979
JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18624292 RGD:5135483 NCBI chr  X:55,882,433...55,884,582
Ensembl chr  X:55,882,433...55,884,582
JBrowse link
G DNASE1 deoxyribonuclease 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28780505 NCBI chr 6:37,596,735...37,599,953
Ensembl chr 6:37,595,911...37,599,827
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:17425601, PMID:20209309 RGD:4140425 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism
associated with Otitis media;protein:increased expression:serum:
CTD
RGD
PMID:19352211, PMID:21937650 RGD:8142352 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698
JBrowse link
G IL10 interleukin 10 severity ISO RGD PMID:20209309 RGD:4140425 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G IL13 interleukin 13 ISO RGD PMID:18250447 RGD:4145641 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388
JBrowse link
G IL17A interleukin 17A severity ISO protein:increased expression:plasma RGD PMID:19738511 RGD:4889103 NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513
JBrowse link
G IL18 interleukin 18 ISO DNA:polymorphism:intron:rs360721 (human) RGD PMID:18043444, PMID:20130064 RGD:4889550, RGD:4889584 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
JBrowse link
G IL1RL1 interleukin 1 receptor like 1 ISO RGD PMID:11283151 RGD:5144238 NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:20639494 RGD:5147443 NCBI chr 2:29,892,130...29,948,926
Ensembl chr 2:29,894,125...29,944,643
JBrowse link
G IL33 interleukin 33 ISO RGD PMID:26044350, PMID:28771101 RGD:11342984, RGD:39939029 NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721
JBrowse link
G IL5 interleukin 5 severity ISO RGD PMID:25410867 RGD:11354937 NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269
JBrowse link
G IL5RA interleukin 5 receptor subunit alpha ISO protein:decreased expression:blood, eosinophil RGD PMID:16734609 RGD:5128618 NCBI chr20:14,309,805...14,349,433
Ensembl chr20:14,314,227...14,343,793
JBrowse link
G IL6 interleukin 6 severity ISO associated with Otitis media;protein:increased expression:serum:
protein:increased expression:nasal mucus
RGD PMID:19352211, PMID:20622030 RGD:4143259, RGD:8142352 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G IL9 interleukin 9 susceptibility ISO DNA:SNPs: :rs2069885, rs1799962 (human) RGD PMID:19915054, PMID:20503287 RGD:5128684, RGD:5128685 NCBI chr11:23,808,919...23,814,085
Ensembl chr11:23,811,117...23,814,079
JBrowse link
G IRF1 interferon regulatory factor 1 ISO protein:increased expression:dorsal root ganglion RGD PMID:20045913 RGD:5128775 NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608
JBrowse link
G LOC610540 pulmonary surfactant-associated protein A-like susceptibility ISO protein:decreased expression:lung
DNA:polymorphisms, haplotype: (human)
RGD PMID:10194154, PMID:19287351 RGD:4143439, RGD:4143495 NCBI chr 4:29,430,139...29,434,640 JBrowse link
G MMP2 matrix metallopeptidase 2 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming ISO associated with Respiratory Hypersensitivity; protein:increased expression:lung RGD PMID:15130904 RGD:5131205 NCBI chr18:45,471,232...45,498,961 JBrowse link
G NGF nerve growth factor ISO RGD PMID:19824047 RGD:4891065 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:19824047 RGD:4891065 NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274
JBrowse link
G PDCD1 programmed cell death 1 ISO protein:increased expression:CD4 Tcell, CD8 Tcell from lung:
protein:increased expression: CD8 Tcell from nasal wash:
RGD PMID:25465101 RGD:11056952 NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723
JBrowse link
G PDE12 phosphodiesterase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055709 NCBI chr20:32,884,819...32,890,995
Ensembl chr20:32,886,972...32,890,890
JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 treatment ISO RGD PMID:23018837 RGD:11554170 NCBI chr17:4,488,202...4,508,705
Ensembl chr17:4,487,957...4,507,181
JBrowse link
G SARM1 sterile alpha and TIR motif containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr 9:42,620,878...42,639,662
Ensembl chr 9:42,622,538...42,639,590
JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO RGD PMID:12847279 RGD:5144208 NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482
JBrowse link
G SFTPB surfactant protein B severity ISO protein:decreased expression:lung
DNA:SNPs:promoter, cds, intron:-32G>T (rs2077079), p.T131I (rs1130866), 5781A>C (rs2040349) (human)
RGD PMID:10194154, PMID:17498296 RGD:4143382, RGD:4143439 NCBI chr17:39,419,305...39,428,513
Ensembl chr17:39,386,584...39,426,229
JBrowse link
G SFTPC surfactant protein C ISO DNA:polymorphism: :138A>C, 186A>G (human) RGD PMID:17121584, PMID:19304906 RGD:4144065, RGD:4144116 NCBI chr25:35,088,295...35,090,995
Ensembl chr25:35,088,279...35,091,457
JBrowse link
G SFTPD surfactant protein D susceptibility ISO protein:decreased expression:lung
DNA:polymorphisms: :p.M11T, p.A160T (human
RGD PMID:10194154, PMID:19287351 RGD:4143439, RGD:4143495 NCBI chr 4:29,394,755...29,407,499
Ensembl chr 4:29,394,678...29,407,293
JBrowse link
G TAC1 tachykinin precursor 1 ISO mRNA,protein:increased expression:lung RGD PMID:10516226 RGD:5147822 NCBI chr14:22,631,106...22,640,283
Ensembl chr14:22,632,642...22,640,258
JBrowse link
G TACR1 tachykinin receptor 1 treatment ISO RGD PMID:10516226 RGD:5147822 NCBI chr17:48,038,010...48,178,971
Ensembl chr17:48,038,010...48,178,971
JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chr20:54,948,237...54,961,996
Ensembl chr20:54,959,525...54,961,780
JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:19019963 RGD:4889534 NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241
JBrowse link
G TLR3 toll like receptor 3 ISO RGD PMID:16424225 RGD:5129224 NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247
JBrowse link
G TLR4 toll like receptor 4 no_association
susceptibility
ISO DNA:SNPs:cds:p.D299G, T399I (human)
DNA:SNP:cds:p.D299G (human)
DNA:polymorphisms:cds:p.D259G, T359I (human)
RGD PMID:17264400, PMID:17449325, PMID:17709532, PMID:19019963 RGD:4144161, RGD:4144164, RGD:4144167, RGD:4889534 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
JBrowse link
G TLR6 toll like receptor 6 ISO RGD PMID:19019963 RGD:4889534 NCBI chr 3:73,504,357...73,523,964
Ensembl chr 3:73,520,706...73,523,099
JBrowse link
G TLR7 toll like receptor 7 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chr  X:9,331,243...9,360,461
Ensembl chr  X:9,314,815...9,359,603
JBrowse link
G TLR8 toll like receptor 8 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chr  X:9,381,159...9,399,938 JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:Bronchoalveolar lavage fluid RGD PMID:15791294 RGD:4145715 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TSLP thymic stromal lymphopoietin sexual_dimorphism ISO mRNA:increased expression:lung (mouse)
protein:increased expression:nasal mucus (human)
RGD PMID:27156176, PMID:28471975, PMID:31076663 RGD:38549376, RGD:38596342, RGD:38596346 NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696
JBrowse link
Respirovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL28 C-C motif chemokine ligand 28 ISO mRNA:increased expression:lung (mouse) RGD PMID:17954569 RGD:4892194 NCBI chr 4:66,567,139...66,597,310
Ensembl chr 4:66,566,989...66,597,459
JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:17641009 RGD:4892127 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:lung RGD PMID:16816895 RGD:5130923 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
subacute sclerosing panencephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO DNA:insertion/deletion: RGD PMID:16741935 RGD:40400901 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358
JBrowse link
Vesicular Stomatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EHMT2 euchromatic histone lysine methyltransferase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:26418342 NCBI chr12:1,341,202...1,354,602
Ensembl chr12:1,341,191...1,354,584
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12699
    disease by infectious agent 1679
      viral infectious disease 1398
        RNA Virus Infections 1247
          Mononegavirales Infections 77
            Filoviridae Infections + 1
            Paramyxoviridae Infections + 60
            Rhabdoviridae Infections + 2
            borna disease 16
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.