Term:Experimental Autoimmune Myasthenia Gravis
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Accession:DOID:9008286 term browser browse the term
Definition:Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Synonyms:exact_synonym: EAMG;   Experimental Myasthenia;   Experimental Myasthenia Gravis;   Experimental Myasthenias;   Passive Transfer Experimental Autoimmune Myasthenia Gravis
 primary_id: MESH:D020720
 alt_id: RDO:0007422
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Experimental Autoimmune Myasthenia Gravis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arpc5 actin related protein 2/3 complex, subunit 5 JBrowse link 13 70,174,970 70,183,879 RGD:11049469
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:7401263
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1600670
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:8547800
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:11041161
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit JBrowse link 3 60,445,657 60,460,724 RGD:704386
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:2315588
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:2311364
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:1598501
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:1598501
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:1626617
G Il23r interleukin 23 receptor JBrowse link 4 98,203,788 98,306,729 RGD:5108250
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:2325986
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:4889981
G Musk muscle associated receptor tyrosine kinase JBrowse link 5 75,392,790 75,498,694 RGD:2317084
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:9686077
G Rapsn receptor-associated protein of the synapse JBrowse link 3 79,859,815 79,869,486 RGD:8549750

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Path 1
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  disease 14920
    Animal Diseases 1571
      Animal Disease Models 1537
        Experimental Nervous System Autoimmune Disease 246
          Experimental Autoimmune Myasthenia Gravis 17
Path 2
Term Annotations click to browse term
  disease 14920
    disease of anatomical entity 14086
      Immune & Inflammatory Diseases 3003
        immune system disease 2425
          Autoimmune Diseases 1455
            autoimmune hypersensitivity disease 1169
              autoimmune disease of the nervous system 402
                autoimmune disease of peripheral nervous system 46
                  myasthenia gravis 30
                    Experimental Autoimmune Myasthenia Gravis 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.