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ONTOLOGY REPORT - ANNOTATIONS


Term:Primary Progressive Aphasia
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Accession:DOID:9008293 term browser browse the term
Definition:A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)
Synonyms:exact_synonym: Aphasia, Primary Progressive, Susceptibility To;   Mesulam Syndrome;   Mesulam's Syndrome;   Primary Progressive Aphasias
 primary_id: MESH:D018888;   RDO:0007243
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Primary Progressive Aphasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:8554872
G Prnp prion protein JBrowse link 3 124,515,917 124,531,320 RGD:8554872
Primary Progressive Nonfluent Aphasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16017
    Diseases of the Aged 1224
      dementia 663
        Primary Progressive Aphasia 3
          Primary Progressive Nonfluent Aphasia 1
Path 2
Term Annotations click to browse term
  disease 16017
    disease of anatomical entity 15273
      nervous system disease 10762
        central nervous system disease 8856
          brain disease 8144
            disease of mental health 5768
              developmental disorder of mental health 2918
                specific developmental disorder 2099
                  communication disorder 186
                    language disorder 110
                      speech disorder 46
                        aphasia 5
                          Primary Progressive Aphasia 3
                            Primary Progressive Nonfluent Aphasia 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.