ONTOLOGY REPORT - ANNOTATIONS


Term:Multiple Endocrine Neoplasia
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Accession:DOID:9008931 term browser browse the term
Definition:A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
Synonyms:exact_synonym: Multiple Endocrine Adenomatoses;   Multiple Endocrine Adenomatosis;   Multiple Endocrine Adenopathies;   Multiple Endocrine Adenopathy;   familial endocrine adenomatoses;   familial endocrine adenomatosis;   multiple endocrine neoplasia syndromes;   multiple endocrine neoplasms
 primary_id: MESH:D009377
 alt_id: RDO:0006198
 xref: OMIM:PS131100
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Multiple Endocrine Neoplasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:2293616
RGD:8554872
G Cdkn1bwe cyclin-dependent kinase inhibitor 1B; white eye mutation RGD:2293616
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:12904888
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:12904888
G Gpr19 G protein-coupled receptor 19 JBrowse link 4 168,639,930 168,668,345 RGD:8554872
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:8554872
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:11554173
RGD:8554872
familial medullary thyroid carcinoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:8554872
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:7240710
RGD:8554872
G Prlr prolactin receptor JBrowse link 2 60,131,410 60,325,686 RGD:13592920
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:7240710
RGD:8554872
RGD:11554173
multiple endocrine neoplasia type 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:2317763
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:2317347
RGD:8554872
RGD:11554173
RGD:7240710
RGD:1601327
RGD:1601326
RGD:2317327
RGD:2317303
RGD:2317313
RGD:2317331
RGD:619590
RGD:2317293
RGD:2317314
RGD:2317334
RGD:2317335
RGD:1581203
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:8554872
multiple endocrine neoplasia type 2A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:2324920
RGD:8554872
RGD:11554173
RGD:7240710
multiple endocrine neoplasia type 2B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:7240710
RGD:8554872
multiple endocrine neoplasia type 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:7240710
RGD:8554872
G Gpr19 G protein-coupled receptor 19 JBrowse link 4 168,639,930 168,668,345 RGD:8554872
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14875
    disease of cellular proliferation 5577
      Hereditary Neoplastic Syndromes 647
        Multiple Endocrine Neoplasia 12
          multiple endocrine neoplasia type 1 3
          multiple endocrine neoplasia type 2A + 4
          multiple endocrine neoplasia type 2B + 1
          multiple endocrine neoplasia type 4 3
Path 2
Term Annotations click to browse term
  disease 14875
    Developmental Diseases 7711
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 6750
        genetic disease 5997
          monogenic disease 2855
            autosomal genetic disease 2137
              autosomal dominant disease 1098
                Multiple Endocrine Neoplasia 12
                  multiple endocrine neoplasia type 1 3
                  multiple endocrine neoplasia type 2A + 4
                  multiple endocrine neoplasia type 2B + 1
                  multiple endocrine neoplasia type 4 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.