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ONTOLOGY REPORT - ANNOTATIONS


Term:cerebral amyloid angiopathy
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Accession:DOID:9246 term browser browse the term
Definition:A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
Synonyms:exact_synonym: Cerebral Amyloid Angiopathies;   Congophilic Angiopathies;   Congophilic Angiopathy;   Hereditary cerebral haemorrhage with amyloidosis - Dutch type;   Sporadic Cerebral Amyloid Angiopathy;   dutch hereditary cerebral amyloid angiopathy
 primary_id: MESH:D016657;   RDO:0004200
 xref: ORDO:85458
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cerebral amyloid angiopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aoc3 amine oxidase, copper containing 3 JBrowse link 10 89,251,370 89,259,313 RGD:2313919
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:5508213
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:11554173
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:11554173
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:5148012
G Ccr1 C-C motif chemokine receptor 1 JBrowse link 8 132,996,646 133,002,201 RGD:5688166
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:13592920
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1600811
RGD:13801026
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:1580993
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1331525
APP-related cerebral amyloid angiopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:11554173
RGD:8554872
RGD:7240710
CST3-related cerebral amyloid angiopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:8554872
G Cst3 cystatin C JBrowse link 3 143,219,671 143,223,544 RGD:7240710
RGD:8554872
RGD:11554173
ITM2B-related cerebral amyloid angiopathy 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:1358403
RGD:8554872
RGD:7240710
ITM2B-related cerebral amyloid angiopathy 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itm2b integral membrane protein 2B JBrowse link 15 55,254,703 55,277,713 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15610
    Nutritional and Metabolic Diseases 4393
      disease of metabolism 4393
        Proteostasis Deficiencies 267
          amyloidosis 50
            cerebral amyloid angiopathy 11
              APP-related cerebral amyloid angiopathy 1
              Amyloid Angiopathy 0
              CST3-related cerebral amyloid angiopathy + 3
              ITM2B-related cerebral amyloid angiopathy 1 1
              ITM2B-related cerebral amyloid angiopathy 2 1
Path 2
Term Annotations click to browse term
  disease 15610
    disease of anatomical entity 14968
      nervous system disease 10400
        central nervous system disease 8547
          brain disease 7903
            cerebrovascular disease 799
              intracranial arterial disease 241
                cerebral arterial disease 195
                  cerebral amyloid angiopathy 11
                    APP-related cerebral amyloid angiopathy 1
                    Amyloid Angiopathy 0
                    CST3-related cerebral amyloid angiopathy + 3
                    ITM2B-related cerebral amyloid angiopathy 1 1
                    ITM2B-related cerebral amyloid angiopathy 2 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.