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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:intracranial hypertension
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Accession:DOID:9428 term browser browse the term
Definition:Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.
Synonyms:exact_synonym: Elevated Intracranial Pressure;   ICP (Intracranial Pressure) Elevation;   ICP (Intracranial Pressure) Increase;   elevated ICP (intracranial pressure);   intracranial pressure increase;   raised intracranial pressure
 primary_id: MESH:D019586
 alt_id: RDO:0005821
 xref: NCI:C84791
For additional species annotation, visit the Alliance of Genome Resources.


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intracranial hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc4a10 solute carrier family 4 member 10 ISO CTD Direct Evidence: therapeutic CTD PMID:18165320 NCBI chr 3:47,995,812...48,287,897
Ensembl chr 3:47,995,959...48,287,910
JBrowse link
hypertensive encephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor treatment IEP RGD PMID:24730417 RGD:10059400 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IDA Strain: SHRSP RGD PMID:20671072 RGD:5509943 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
Posterior Leukoencephalopathy Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29483653 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      nervous system disease 10897
        central nervous system disease 9045
          brain disease 8370
            intracranial hypertension 4
              hypertensive encephalopathy + 3
              pseudotumor cerebri + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.